Original title: Synthesis of new potential inhibitors of 5´-nucleotidases
Authors: Šimák, Ondřej ; Pachl, Petr ; Brynda, Jiří ; Rosenberg, Ivan
Document type: Papers
Conference/Event: Chemistry of Nucleic Acid Components /15./, Český Krumlov (CZ), 2011-06-05 / 2011-06-10
Year: 2011
Language: eng
Abstract: The work deals with the synthesis of potential inhibitors of 5´-nucleotidases. The phosphonobenzylidene ring of a phosphonate nucleotide derivative was recognized as a target for proposed synthetic modifications. Substituents selected on the basis of a docking study, mostly the electronegative ones, should be suitable for the formation of additional hydrogen bonds, and thus the increased inhibition of the enzymes.
Keywords: nucleotide analogs; phosphonate nucleotides; phosphonobenzylidene ring; potential 5´-nucleotidase inhibitors
Project no.: CEZ:AV0Z40550506 (CEP), CEZ:AV0Z50520514 (CEP), GA203/09/0820 (CEP), KAN200520801 (CEP), LC06077 (CEP)
Funding provider: GA ČR, GA AV ČR, GA MŠk
Host item entry: Chemistry of Nucleic Acid Components. 15th Symposium, ISBN 978-80-86241-37-1

Institution: Institute of Organic Chemistry and Biochemistry AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0198844

Permalink: http://www.nusl.cz/ntk/nusl-55835


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Research > Institutes ASCR > Institute of Organic Chemistry and Biochemistry
Conference materials > Papers