Original title:
Synthesis of new potential inhibitors of 5´-nucleotidases
Authors:
Šimák, Ondřej ;
Pachl, Petr ;
Brynda, Jiří ;
Rosenberg, Ivan
Document type: Papers
Conference/Event: Chemistry of Nucleic Acid Components /15./ , Český Krumlov (CZ), 2011-06-05 / 2011-06-10
Year:
2011
Language:
eng
Abstract:
The work deals with the synthesis of potential inhibitors of 5´-nucleotidases. The phosphonobenzylidene ring of a phosphonate nucleotide derivative was recognized as a target for proposed synthetic modifications. Substituents selected on the basis of a docking study, mostly the electronegative ones, should be suitable for the formation of additional hydrogen bonds, and thus the increased inhibition of the enzymes.
Keywords:
nucleotide analogs ;
phosphonate nucleotides ;
phosphonobenzylidene ring ;
potential 5´-nucleotidase inhibitors
Project no.: CEZ:AV0Z40550506 (
CEP ),
CEZ:AV0Z50520514 (
CEP ),
GA203/09/0820 (
CEP ),
KAN200520801 (
CEP ),
LC06077 (
CEP )
Funding provider: GA ČR, GA AV ČR, GA MŠk
Host item entry: Chemistry of Nucleic Acid Components. 15th Symposium, ISBN 978-80-86241-37-1
Institution: Institute of Organic Chemistry and Biochemistry AS ČR
(
web )
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0198844
Permalink: http://www.nusl.cz/ntk/nusl-55835
The record appears in these collections: Research > Institutes ASCR > Institute of Organic Chemistry and Biochemistry Conference materials > Papers