Original title: New strategies in synthesis of acyclic nucleoside phosphonate prodrugs
Authors: Krečmerová, Marcela ; Tichý, Tomáš ; Blažek, Jiří ; Pomeisl, Karel
Document type: Papers
Conference/Event: Chemistry of Nucleic Acid Components /15./, Český Krumlov (CZ), 2011-06-05 / 2011-06-10
Year: 2011
Language: eng
Abstract: New syntheses of acyclic nucleoside phosphonate prodrugs including dioxolenone derivatives, functionalized alkoxyalkyl esters, utilization of hexafluorophosphate coupling agents and enzymatic glycosylations were described. Comparison of antiviral activities of diverse prodrugs was performed.
Keywords: ANP; ester prodrugs; glycosylation; HATU; phophonates; PyBOP; PyBroP
Project no.: CEZ:AV0Z40550506 (CEP), 1M0508 (CEP), 1UC1 AI062540-01
Funding provider: GA MŠk, NIH
Host item entry: Chemistry of Nucleic Acid Components. 15th Symposium, ISBN 978-80-86241-37-1

Institution: Institute of Organic Chemistry and Biochemistry AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0198699

Permalink: http://www.nusl.cz/ntk/nusl-55811


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Research > Institutes ASCR > Institute of Organic Chemistry and Biochemistry
Conference materials > Papers