Název:
Continuous monitoring of anthraquinone-based anticancer drugs by amperometric technique
Autoři:
Skalová, Štěpánka ; Fischer, J. ; Barek, J. ; Navrátil, Tomáš ; Krejčí, J. ; Kučerová, R. ; Vyskočil, V. Typ dokumentu: Příspěvky z konference Konference/Akce: International Students Conference on Modern Analytical Chemistry, Prague (CZ), 20190919
Rok:
2019
Jazyk:
eng
Abstrakt: This contribution is focused on the development of electroanalytical methods for the monitoring of anthraquinone-based anticancer drugs in physiological solution by combination of liquid-flow system and dialysis catheter, possibly inserted into blood circulation of patients. For this purpose, amperometric detection with dual glassy carbon electrode was developed and derivate of these drugs, anthraquinone-2-sulphonate, was used as a model compound. Two different flow rates of carrier solution (physiological solution) were tested (specifically, 1 and 5 mu L min(-1)) and the dependence of peak currents of anthraquinone-2-sulphonate on its concentration was verified
Klíčová slova:
amperometric detection; anthracyclines; anthraquinone-2-sulphonate Číslo projektu: GA17-05387S (CEP), GA17-03868S (CEP) Poskytovatel projektu: GA ČR, GA ČR Zdrojový dokument: PROCEEDINGS OF THE 15TH INTERNATIONAL STUDENTS CONFERENCE MODERN ANALYTICAL CHEMISTRY, ISBN 978-80-7444-068-7