Název: Formulace a charakterizace PLGA nanočástic s oximy
Překlad názvu: Formulation and characterization of oxims loaded PLGA nanoparticles
Autoři: Hafezi, Ramin ; Šnejdrová, Eva (vedoucí práce) ; Paraskevopoulos, Georgios (oponent)
Typ dokumentu: Diplomové práce
Rok: 2021
Jazyk: eng
Abstrakt: Thesis title: Formulation and characterization of oxime loaded PLGA nanoparticles Author: Ramin Hafezi Supervisor: PharmDr. Eva Šnejdrová, Ph.D. Advisor: PharmDr. Juraj Martiška, Ph.D. Department: Department of Pharmaceutical Technology The diploma thesis was focused on PLGA nanoparticles (NPs) which could be loaded with oximes, prepared by a double emulsion technique, and characterised by size, polydispersity and zeta potential. The theoretical part deals with the most common methods of the NPs preparation, the polymers and stabilizers employed, and drug delivery to brain. In the experimental part the effect of various formulation factors on NP characteristics were studied: linear or branched PLGA derivative, the concentrations of polymer, the volumes of primary emulsion. Dichloromethane (DCM) or Dimethyl sulfoxide (DMSO) as solvent for polymers were used and Poloxamer 407 or Didodecyldimethylammonium bromide (DDAB) as an outer phase stabilizer were employed. By comparison among the collected results, it seemed 1% A2 in DMSO and stabilization with poloxamer 407 could be best candidate for the oxime loaded drug delivery systems as it was possible to produce nanoparticles with size from 152 to 168 nm with PDI of below 0.15. Electrostatic stability in case of using DDAB was resulted excellent and...
Klíčová slova: disoluce; enkapsulační účinnost; nanočástice; rifampicin; velikost částic; zeta potenciál; dissolution; encapsulation efficiency; nanoparticles; particles size; rifampicin; zeta potential

Instituce: Fakulty UK (VŠKP) (web)
Informace o dostupnosti dokumentu: Dostupné v digitálním repozitáři UK.
Původní záznam: http://hdl.handle.net/20.500.11956/126182

Trvalý odkaz NUŠL: http://www.nusl.cz/ntk/nusl-445737


Záznam je zařazen do těchto sbírek:
Školství > Veřejné vysoké školy > Univerzita Karlova > Fakulty UK (VŠKP)
Vysokoškolské kvalifikační práce > Diplomové práce