Original title: Study of chemical stability of antivirally active 5-azacytosine acyclic nucleoside phosphonate using NMR spectroscopy
Translated title: Studium chemické stability antivirově aktivních 5-azacytosin acyklických nukleosidfosfonátů pomocí NMR spektroskopie
Authors: Dračínský, Martin ; Krečmerová, Marcela ; Holý, Antonín
Document type: Papers
Conference/Event: Symposium on Chemistry of Nucleic Acid Components /14./, Český Krumlov (CZ), 2008-06-08 / 2008-06-13
Year: 2008
Language: eng
Abstract: [eng] [cze]
Hydrolytic decomposition of four 5-azacytosine acyclic nucleoside phosphonates was studied. Products of the decomposition are carbamoylguanidine derivatives. Stability and decomposition products of HPMP-5-azaC (a 5-azacytosine derivative with strong antiviral activity) differ from the other derivatives. Byly studovány hydrolytické rozklady čtyř 5-azacytosin acyklických nukleosidfosfonátů. Produktem rozkladu jsou karbamoylguanidinové deriváty. Stabilita a rozkladné produkty HPMP-5-azaC (5-azacytosinový derivát s vysokou protivirovou aktivitou) se odlišují od ostatních derivátů.
Keywords: 5-azacytosine; acyclic nucleoside phosphonates; decomposition
Project no.: CEZ:AV0Z40550506 (CEP), 1M0508 (CEP), 1QS400550501 (CEP)
Funding provider: GA MŠk, GA AV ČR
Host item entry: Chemistry of Nucleic Acid Components, ISBN 978-80-86241-29-6

Institution: Institute of Organic Chemistry and Biochemistry AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0162021

Permalink: http://www.nusl.cz/ntk/nusl-38984


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Research > Institutes ASCR > Institute of Organic Chemistry and Biochemistry
Conference materials > Papers