Home > Conference materials > Papers > Study of chemical stability of antivirally active 5-azacytosine acyclic nucleoside phosphonate using NMR spectroscopy
Original title:
Study of chemical stability of antivirally active 5-azacytosine acyclic nucleoside phosphonate using NMR spectroscopy
Translated title:
Studium chemické stability antivirově aktivních 5-azacytosin acyklických nukleosidfosfonátů pomocí NMR spektroskopie
Authors:
Dračínský, Martin ; Krečmerová, Marcela ; Holý, Antonín Document type: Papers Conference/Event: Symposium on Chemistry of Nucleic Acid Components /14./, Český Krumlov (CZ), 2008-06-08 / 2008-06-13
Year:
2008
Language:
eng Abstract:
[eng][cze] Hydrolytic decomposition of four 5-azacytosine acyclic nucleoside phosphonates was studied. Products of the decomposition are carbamoylguanidine derivatives. Stability and decomposition products of HPMP-5-azaC (a 5-azacytosine derivative with strong antiviral activity) differ from the other derivatives.Byly studovány hydrolytické rozklady čtyř 5-azacytosin acyklických nukleosidfosfonátů. Produktem rozkladu jsou karbamoylguanidinové deriváty. Stabilita a rozkladné produkty HPMP-5-azaC (5-azacytosinový derivát s vysokou protivirovou aktivitou) se odlišují od ostatních derivátů.
Keywords:
5-azacytosine; acyclic nucleoside phosphonates; decomposition Project no.: CEZ:AV0Z40550506 (CEP), 1M0508 (CEP), 1QS400550501 (CEP) Funding provider: GA MŠk, GA AV ČR Host item entry: Chemistry of Nucleic Acid Components, ISBN 978-80-86241-29-6
Institution: Institute of Organic Chemistry and Biochemistry AS ČR
(web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences. Original record: http://hdl.handle.net/11104/0162021