Original title: Affinity capillary electrophoresis applied to chiral separations of diquats and to determination of the stability constants of their complexes with sulfated cyclodextrins
Authors: Kašička, Václav ; Bílek, Jan ; Koval, Dušan ; Sázelová, Petra ; Talele, Harish Ramesh ; Severa, Lukáš ; Reyes Gutierrez, Paul Eduardo ; Teplý, Filip
Document type: Papers
Conference/Event: Advances in Chromatography and Electrophoresis & Chiranal 2018, Olomouc (CZ), 20180129
Year: 2018
Language: eng
Abstract: Affinity capillary electrophoresis (ACE) using an aqueous 22/35 mM sodium/phosphate buffer, pH 2.5, as the background electrolyte (BGE), and 6 mM randomly highly sulfated alpha-, beta- and gamma-cyclodextrins (CDs) as chiral selectors has been successfully applied for separation of (P)- and (M)-enantiomers of a series of eleven new diquats (DQs) and for estimation of the strength of their complexes with the above CDs. The apparent stability constants of the DQs-CDs complexes were determined from the simultaneous ACE measurements of the dependence of effective electrophoretic mobilities of (P)- and (M)-enantiomers of DQs on the concentrations of CDs in the BGE by nonlinear regression analysis. The DQs enantiomers formed strong complexes with all three types of CDs with the apparent stability constants in the range (7.80 547.4) × 103 L/mol.
Keywords: affinity capillary electrophoresis; chiral separations; diquats
Project no.: GA15-01948S (CEP), GA17-10832S (CEP)
Funding provider: GA ČR, GA ČR
Host item entry: Advances in Chromatography and Electrophoresis & Chiranal 2018

Institution: Institute of Organic Chemistry and Biochemistry AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0286857

Permalink: http://www.nusl.cz/ntk/nusl-386556


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Research > Institutes ASCR > Institute of Organic Chemistry and Biochemistry
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