Hlavní stránka > Konferenční materiály > Příspěvky z konference > Partial deletion of the RPS0A-binding domain of TIF32/eIF3A affects 40S ribosome-association of the multifactor complex and severely impairs reinitiation on the GCN4 mRNA leader
Název:
Partial deletion of the RPS0A-binding domain of TIF32/eIF3A affects 40S ribosome-association of the multifactor complex and severely impairs reinitiation on the GCN4 mRNA leader
Překlad názvu:
Delece RPS0A-vazebné domény TIF32/eIF3A brání vazbě MFC na 40S ribozóm a blokuje derepresi GCN4 exprese
Autoři:
Szamecz, Bela ; Rutkai, Edit ; Nielsen, K. H. ; Valášek, Leoš Typ dokumentu: Příspěvky z konference Konference/Akce: Translational Control and Non-Coding RNA Meeting, Nové Hrady (CZ), 2006-12-08 / 2006-12-12
Rok:
2006
Jazyk:
eng
Abstrakt: [eng][cze] Yeast Initiation factor 3 (eIF3) occurs together with the eIF2.GTP.Met-tRNAiMet ternary complex (TC) and eIFs 1 and 5 in a pre-formed unit designated the multifactor complex (MFC) that was implicated in playing a critical role in ecient recruitment of TC and mRNA to the 40S ribosomes and stimulation of the post-assembly processes such as scanning and AUG recognition. In ecort to identify binding sites of the MFC on the 40S ribosome, we previously demonstrated that deletion of the rst 199 amino acids of the N-terminal domain (NTD) of the TIF32 subunit of eIF3/eIF3a, in the presence of a wild-type gene, completely eliminated association of the mutant MFC with the 40S ribosome without aecting its overall integrity. In addition, we showed that the TIF32-NTD contains a binding site for the C-terminal domain (CTD) of the small ribosomal protein 0A (RPS0A) that is located on the solvent side of the 40S subunit where the main body of eIF3 was proposed to residePráce pojednáva o studiu inciace translace a specifické úloze translačního iniciačního faktoru eIF3
Klíčová slova:
gcn4; translation Číslo projektu: CEZ:AV0Z50200510 (CEP), The Wellcome Trust grant to LV Poskytovatel projektu: XE Zdrojový dokument: Translational Control and Non-Coding RNA
Instituce: Mikrobiologický ústav AV ČR
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Informace o dostupnosti dokumentu:
Dokument je dostupný v příslušném ústavu Akademie věd ČR. Původní záznam: http://hdl.handle.net/11104/0145412