Hlavní stránka > Konferenční materiály > Příspěvky z konference > The C-terminal domain of eIF3c/NIP1 and eIF3j/HCR1 subunits of yeast eIF3 seem to promote its association with the 40S ribosome by making contacts with the small subunit proteins RPS33/ASC1 and RPS2, respectively
Název:
The C-terminal domain of eIF3c/NIP1 and eIF3j/HCR1 subunits of yeast eIF3 seem to promote its association with the 40S ribosome by making contacts with the small subunit proteins RPS33/ASC1 and RPS2, respectively
Překlad názvu:
C-konc. segment NIP1/eIF3c a HCR1 subjednotky eIF3 umožňují jeho vazbu na 40S ribozóm přes RPS33/ASC1 a RPS22
Autoři:
Rutkai, Edit ; Herrmannová, Anna ; Szamecz, Bela ; Valášek, Leoš Typ dokumentu: Příspěvky z konference Konference/Akce: Translational Control and Non-Coding RNA Meeting, Nové Hrady (CZ), 2006-12-08 / 2006-12-12
Rok:
2006
Jazyk:
eng
Abstrakt: [eng][cze] One of the rst critical steps of protein synthesis is the recruitment of the eIF2.GTP.Met-tRNAiMet ternary complex (TC) to the 40S ribosome. In yeast, the TC occurs together with eIFs 1, 3 and 5 in a Multifactor complex (MFC) that was shown to function as an important intermediate of the initiation pathway. Our previous study determined several critical domains of the TIF32 and NIP1 subunits of yeast eIF3, the deletion of which, in the background of a wild type gene, signifcantly aected binding of the mutant MFC to the 40S ribosomes. Subsequent identifcation of the two contact points between TIF32 and components of the 40S ribosome enabled us to propose that the major body of the eIF3 complex resides under the head region on the solvent side of the small ribosomal subunit facing down towards its left footPráce pojednáva o studiu inciace translace a specifické úloze translačního iniciačního faktoru eIF3
Klíčová slova:
eif3; translation Číslo projektu: CEZ:AV0Z50200510 (CEP), The Wellcome Trust grant to LV, FIC NIH GRIP grant to LV Poskytovatel projektu: GB, XE Zdrojový dokument: Translational Control and Non-Coding RNA
Instituce: Mikrobiologický ústav AV ČR
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Informace o dostupnosti dokumentu:
Dokument je dostupný v příslušném ústavu Akademie věd ČR. Původní záznam: http://hdl.handle.net/11104/0145410