Funkční zobrazovaní korových evokovaných potenciálů při bolestivé a nebolestivé stimulaci u zdravých dobrovolníků a pacientů s chronickou bolestí

Poláček, Hubert

A close relationship between painful and non-painful (somatosensory) percepction was noticed already in the past centuries and led into development of many analgesic methods. Only basic neuroanatomical and neurophysiological research using animal models of nociception was able to shed more light on their proper mechanisms until the era of modern non- invasive imaging methods. The main aim of this thesis was to analyze non-invasively, in human volunteers and patients with chronic pain, spatiotemporal relations between brain evoked responses to painful (or aversive) and non-painful stimuli. In next step, to discuss the roles of different engaged mechanisms in found interactions and suggest recommendations for further research of pain. 4 experimental studies (3 in healthy volunteers and 1 in patients with failed back surgery syndrome) are presented. Using high-resolution EEG, phasic electrical stimulation of median, tibial or sural nerve(s), and source analysis of recorded data, modulations of all repersentative components of somatosensory evoked potentials (SEPs) by several interfering conditions were analyzed. In healthy volunteers, effects of heterotopic repetitive heat pain administered to the right side of the body (ipsilateral to electrically stimulated nerve) were tested in Experiment 1 (compared to the...

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