Název: Studium skládání a pučení částic viru myšího tumoru prsní žlázy MMTV
Překlad názvu: Study of the assembly and budding of mouse mammary tumor virus MMTV
Autoři: Hoboth, Peter ; Zábranský, Aleš (vedoucí práce) ; Forstová, Jitka (oponent)
Typ dokumentu: Diplomové práce
Rok: 2009
Jazyk: slo
Abstrakt: Mouse mammary tumor virus (MMTV) is a prototypical member of the Betaretrovirus genus characterized by the ability to preassemble viral particles in the cytoplasm of the host cells. Intracellularly preassembled particles are subsequently transported to the plasma membrane being enveloped by a lipid bilayer and released from the cell in the process referred to as budding. Retrovirus particle assembly is driven by the Gag polyprotein precursor, which is cleaved in the maturation process by virus-encoded protease to liberate multiple structural proteins. The matrix (MA), capsid (CA) and nucleocapsid (NC) protein domains that are common to all retroviruses and in the case of MMTV, also the noncanonical domains, pp21, p3, p8 and "n", located between MA and CA domain are present. The role of these specific domains remains undefined. The retroviral budding is stimulated by short peptide motifs, so-called late (L) domains, located within Gag sequence. These L domains mediate interactions with cellular proteins normally involved in the biogenesis of the multivesicular bodies and protein sorting. Three types of the L domains have been identified to date, with the consensus of the amino acid sequences (i) P(T/S)AP, (ii) YP(x)nL (where x represents any amino acid and n≤3) and (iii) PPxY. Disruption of the L domain...

Instituce: Fakulty UK (VŠKP) (web)
Informace o dostupnosti dokumentu: Dostupné v digitálním repozitáři UK.
Původní záznam: http://hdl.handle.net/20.500.11956/25357

Trvalý odkaz NUŠL: http://www.nusl.cz/ntk/nusl-280337


Záznam je zařazen do těchto sbírek:
Školství > Veřejné vysoké školy > Univerzita Karlova > Fakulty UK (VŠKP)
Vysokoškolské kvalifikační práce > Diplomové práce