Original title: Vliv akutního hladovění a diabetes mellitus 2. typu na inzulínovou rezistenci a energetický metabolismus u obézních
Translated title: Effects of acute starvation and of type 2 diabetes mellitus upon insulin resistance and substrate utilization in obese subjects
Authors: Duška, František ; Anděl, Michal (advisor) ; Haluzík, Martin (referee) ; Mourek, Jindřich (referee) ; Stárka, Luboslav (referee)
Document type: Doctoral theses
Year: 2007
Language: cze
Abstract: [cze] [eng]
Aplikace velmi nízké kalorické stravy nebo dokonce krátkodobého hladovění jsou široce používány v klinické praxi s cílem zlepšit metabolické kompenzace nemocných s diabetes mellitus 2. typu. I když výhody snižování hmotnosti se dobře osvědčily u T2DM, jsou mnohem méně známé účinky akutního hladovění. Proto jsme provedli pozorovací a porovnávací studii u klinicky sledovaných pacientů s obezitou a T2DM a bez diabetu porovnávající účinek akutního hladovění v délce 60 hodin, se sledovaním projevů na různé aspekty inzulinové rezistence a endokrinní regulace metabolismu. Very-low calorie diet or even total short-term fasting is widely used in clinical practice in order to improve metabolic compensation of patients with type 2 diabetes mellitus. Although benefits of weight reduction are well proven in T2DM, much less is known about effects of acute starvation, during which the interruption of the afflux of energy substrates is not followed by a major change of body composition. We hypothesize the improvement of insulin effects on glucose metabolism in T2DM as these patients may lack the key metabolic responses which impair insulin sensitivity in lean, non-diabetic subjects. Moreover, we assume according to "thrifty genotype hypothesis" that protein wasting during starvation will be positively related to insulin effects on glucose disposal and negatively related to insulin antilipolytic and antiketogenic effects. In the light of this we designed an observational, prospective, in-hospital study, comparing the effects of 60 hours fast on various aspects of insulin resistance, endocrine regulation and metabolism in 10 patients with T2DM and 10 obese controls without diabetes (OB).

Institution: Charles University Faculties (theses) (web)
Document availability information: Available in the Charles University Digital Repository.
Original record: http://hdl.handle.net/20.500.11956/8395

Permalink: http://www.nusl.cz/ntk/nusl-271015


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Universities and colleges > Public universities > Charles University > Charles University Faculties (theses)
Academic theses (ETDs) > Doctoral theses