|
|
Burn out syndrom at healthcare social workers
Matoušová, Kateřina ; Janečková, Hana (advisor) ; Hudcová, Eliška (referee)
The subject of this bachelor is ,,Burnout syndrome Health social workers" This work was created on the basis of my interest, because I am interested in burnout syndrome and in health social work, which I would like to work in after graduating from this study programme. The thesis deals with the problem of burnout syndrome between health social workers and appeals to critical information about prevention of his rise. The thesis is divided into two parts. In the theoretical part is describes the term burnout syndrome, his symptoms, phases, diagnostics and prevention. Helper syndrome is described here too and caddish with burnout syndrome and stress. Further in this part it describes the profession of a health social worker, his education, competency, ethic, types of clients, multidisciplinarity and at least risks for beginning burnout syndrome in health social workers. The practical part is to utilize the quantity method of research with questionnaire. Participants of this research were 123 people and dates were analyzed by standardized method MBI - Maslach Burnout Inventory.
|
|
|
Alkaloids of leaves of species Liriodendron tulipifera L. and their biological activity II
Matoušová, Kateřina ; Hošťálková, Anna (advisor) ; Chlebek, Jakub (referee)
7 ABSTRACT Matoušová K.: Alkaloids of leaves of species Liriodendron tulipifera L. and their biological activity II. Diploma thesis, Charles University, Faculty of Pharmacy in Hradec Králové, Department of Pharmacognosy and Pharmaceutical Botany, Hradec Králové, 2023. Key words: Liriodendron tulipifera, alkaloids, biological activity. Alkaloids isolated from the leaves of Liriodendron tulipifera L. have been described to have a various biological activity. For Alzheimer's disease (AD) treatment is significant primarily the alkaloid's inhibitory activity towards enzymes acetylcholinesterase and butyrylcholinesterase, which contribute to the pathogenesis of AD. Substances affecting these enzymes represent the main accessible approach to AD treatment, therefore plant-based drug screening remains a relevant topic. An alkaloid extract from the leaves of Liriodendron tulipifera was chosen for an isolation and identification of alkaloids due to the positive results of preliminary tests on its cholinesterase inhibitory activity. The extract was separated by using a flash chromatography. The isolation of alkaloids from selected fractions (no. 81-89 and no. 68-89) was done by the use of preparative thin-layer chromatography. The structural analysis (implemented by NMR and MS) of isolated substances was determined and...
|
|
| |
|
|
Usage of HPLC and UHPLC-MS/MS techniques for clinical research
Matoušová, Kateřina ; Matysová, Ludmila (advisor) ; Doležal, Rafael (referee) ; Kučera, Radim (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of Analytical Chemistry Candidate: Mgr. Kateřina Kučerová Supervisor: assoc. prof. PharmDr. Ludmila Matysová, Ph.D. Consultant: assoc. prof. RNDr. Lenka Kujovská Krčmová, Ph.D. Title of Dissertation Thesis: Usage of HPLC and UHPLC - MS/MS techniques for clinical research The dissertation thesis is dealing with the extraction techniques and with development, optimization and validation of chromatographic methods for the determination of omeprazol which is drug from the group of proton pump inhibitors, and retinol as a new potential biomarker of kidney damage. The theoretical part of the thesis is focused on detailed description of the individual analytes, their clinical significance, options of determination and the matrix in which the target analytes were determined. Furthermore, the preparation of the sample before the analysis is discussed and validation recommendations related to chromatographic methods used in both pharmaceutical analysis and bioanalysis are also mentioned. In the experimental part the development, optimization and validation of UHPLC methods and their subsequent use are described in detail. The pharmaceutical-analytical part of the work describes the determination of omeprazole in new suspension preparations,...
|
|
| |
|
| |
guest ::
RSS feed.