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Racing car chassis
Macháček, Tomáš ; Ramík, Pavel (referee) ; Píštěk, Václav (advisor)
Cílem této bakalářské práce je analýza současných konceptů podvozků závodních okruhových aut. V první části práce je zpracován historický vývoj, charakteristika kol a pneumatik s reprezentací dobře známých produktů. V druhé části je popsán systém odpružení, pružné média a tlumící členy. Systémy odpružení je zde rozdělen na nezávisle a polozávislé zavěšení kol a odpružení pevných náprav. Následující oddíl této práce je zaměřený na standardní kontrolní systémy, jako jsou ABS, ESC a TSC. Závěr přináší rychlé shrnutí této problematiky.
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Brno brownfields by the Svitava river
Macháček, Tomáš ; Ležatka,, Lukáš (referee) ; Májek, Jan (advisor)
The theme of the diploma thesis „Brno brownfields by the Svitava River“ Is design of contemporary city structure in Brno Husovice. The theisis deals with the analysis of the current situation, definition of problems and opportunities in the location and the design, based on these researches. Studied area is located on the riverbank of the Svitava River and is defined by Provazníkova, Dukelská třída and Svitavské nábřeží streets. In these days there are mostly located brownfields of the previous industry parks, storage spaces and development of family houses. The design puts emphasis on the gentle merge with the urban structure of the old Husovice and focuses on using modern architectonic and urban approaches as well, for example on multifunctionality of buildings. The riverbank is revitalised and attractive features are designed here, like the footbridges conneting both river sides and sittable stairs. These designs provide space for leisure time and a water control during the floods as well. The traffic solution is concerned on the design of the new Nová Dukelská street, connecting formerly Zbrojovka industry park and Provazníkova street.
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School of Art Brno
Macháček, Tomáš ; Teplý, Vladimír (referee) ; Odvárka, Antonín (advisor) ; Štěpánek, Ladislav (advisor)
The theme of the project was to create a new building of Brno School of Art. The building is located on the territory of Brno-Kraví hora and is surrounded by the park, astronomical observatory and planetárium and the gardens. The land is located on a sloping terrain and nowadays there are situated old buildings intended for demolition on it. The design reacts to the difficult slope of the land and its aim is not only to create a new building, but also transformation of the land into the attractive park. The object is designed as a single mass consisting of the main building and two attached pavillons. There are branches of studies like fine arts department, musical department, department of dance and the literary drama department. The building is designed to have two floors. Construction is consisting of combination of reinforced concrete skeleton and reinforced concrete walls. The facade is made up of corten metal plates. The parts of the buildings are also Café and multifunctional hall, in which there is possible to hold performances or exhibitions. The aim is to open both the land and school to public and integrate the Kraví hora to the city life
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Design of vehicle suspension stabilizer
Macháček, Tomáš ; Ramík, Pavel (referee) ; Porteš, Petr (advisor)
Tato diplomová práce je zaměřená na stabilizátory u podvozku aut. První část popisuje všeobecné znalosti vlivu naklonění karosérie na jizdní vlastnosti auta a možnosti konstrukčních řešení používaných v praxi. Dále jsou v této části uvedeny nevýhody použití stabilizátoru a jejich náhrady. Nasledující téma se zaměřuje na soutěž Formule Student a její všeobecná pravidla. Hlavní částí této práce je analýza stabilizátoru Formule Ford, na kterou v poslední části této práce navazuje analýza předního a zadního stabilizátoru Formule Student. Byly vytvořené kompletní MBS modely pro přední a zadní zavěšení včetně stabilizátoru. Díky těmto modelům bylo možné provést výpočty klopných tuhostí a pevnostní výpočty. Z těchto výpočtů bylo možné určit vhodné nastavení stabilizátoru. Všechny modely mohou být dále použitelné pro analýzu jízdních vlastností příslušného vozidla.
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The immune response of mice against avian schistosomes: from local to systemic perspective
Majer, Martin ; Macháček, Tomáš (advisor) ; Kverka, Miloslav (referee) ; Sombetzki, Martina (referee)
In the host bodies, helminths often undergo complicated migrations that afflict various organs. Defining the immune response is then usually focused only on isolated spatio-temporal fragments but lacks the whole-body context. To broaden the knowledge about the tissue-specific and systemic immune response, this thesis focused on mice infected with two model species of avian schistosomes of the genus Trichobilharzia. T. regenti penetrates the skin and enters the spinal cord within a few days. Most of the parasites die in the skin which is accompanied by an influx of leukocytes. We confirmed that it was partially mirrored also in skin draining lymph nodes by increasing the T helper 2 cells proportion. Interestingly, there were reduced numbers of T cells in the spleen with an increased proportion of the regulatory T cells. Therefore, we conclude that adaptive systemic response differed and the regulatory phenotype dominated. However, the skin phase-induced eosinophilia in blood influenced the milieu of the central nervous system (CNS). Schistosomula which entered the spinal cord triggered inflammation and enhanced expression of eotaxins, which attracted the eosinophils from the blood into the CNS. The antigen-presenting cells contribute to the communication of CNS with the periphery. We employed and...
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The effect of amyloid beta on viability of selected neuropathogens: challenging the infectious hypothesis of Alzheimer disease
Vosála, Ondřej ; Macháček, Tomáš (advisor) ; Černý, Jan (referee)
Alzheimer's disease is the leading cause of dementia worldwide, affecting millions of individuals. Researchers have identified amyloid beta (A ) as the primary agent responsible for neuropathogenicity, but the factors triggering its overproduction remain uncertain. An relatively new theory, known as the infectious hypothesis, sheds light on this phenomenon by associating the excess production of A with its potential role as an antimicrobial peptide-an element of the innate immune response against neuroinfections. This hypothesis posits a transition from acute physiological overproduction during neuroinfection to a chronically dysregulated and pathological process targeting both pathogens and neural tissue. So far, experimental evidence supporting this theory has been primarily obtained through studies involving viruses or bacteria. Aim of this study was to investigate the role of multicellular pathogens in stimulating A overproduction and, on the other hand, A role in elimination of such infections. Toxocara canis was chosen as a main model of neuropathogenic parasite. Although successful infections were achieved in BALB/c mice, there was no observable increase in A production even after 16 weeks of infection. To further challenge the survivability of Toxocara larvae in increased A concentration in...
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The skin immune response of mice infected with avian schistosomes
Revalová, Alena ; Macháček, Tomáš (advisor) ; Kolářová, Libuše (referee)
Invasion of the mammalian skin by cercariae of avian schistosomes of the genus Trichobilharzia is associated with the skin pathology called cercarial dermatitis (CD). Although the manifestation of CD, characterized by the presence of maculo-papular rash and pruritus, is believed to be linked with the previous sensitization, the role of the infection dose and the specific causative agent is rarely considered. Therefore the skin immune response in mouse pinnae infected by 100, 1000 or 4x100 (repeated infections) cercariae of two Trichobilharzia species - T. regenti and T. szidati - was examined in this work. To compare the effect of these factors (the infection dose and species), a complex approach was ensured by employing both in vivo and in vitro methods. Firstly, histopathological changes in the pinnae were examined by classical histology and infiltrated leukocytes were characterized by flow cytometry. Sera of mice were used to detect the systemic production of cytokines and parasite-specific antibodies. In vitro cultivation of mouse pinnae was used to detect the local production of cytokines. The most remarkable observation was that the infection dose largely impacted the course of the immune response, both locally and systematically. In primary infected mouse pinnae, 100 cercariae of both...
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Immune response against skin-penetrating helminths with a focus on schistosomes
Revalová, Alena ; Macháček, Tomáš (advisor) ; Leštinová, Tereza (referee)
Breaching the vertebrate skin and overcoming the local immunity represents a critical step in the life cycles of many helminths. This bachelor thesis summarized the current knowledge of the skin immune response against schistosomes. Both innate and adaptive immune mechanisms are activated soon after the infection. Despite certain differences between mice and humans, complement, granulocytes and especially CD4+ T-lymphocytes are considered as key players in anti-schistosomal immunity of both species. However, several aspects of the host immune response, such as the initial source of cytokine IL-4, IL-10 or expression pattern of certain co- receptors remain unclear and warrant further research. A comprehensive understanding of the host immune response in the skin as well as the respective parasite immune evasion strategies is needed to boost vaccine development. Keywords: immune response, skin, lymph nodes, helminths, schistosomes
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Using Physical Activities and Music Therapy in Treatment of Persons with Mental Retardation - their Use in ÚSP Brandýs nad Labem
Macháček, Tomáš ; Jebavá, Jana (advisor) ; Strnad, Pavel (referee)
Název: Uplatnění pohyboyých aktivit a muzikoterapie při léčbě 9sob s mentální retardací-využití muzikoterapie a pohybových aktivit v USP v Brandýse nad Labem - Stará Boleslav Using the excercises activities and music therapy in the threatment of persons with the mental retardation- using music therapy and excercise activities in ÚSP Brandýs nad Labem - Stará Boleslav. Cíle práce: Cílem této práce, bylo proniknout do běžného života osob s mentální retardací, seznámit se s jejich životem, různými druhy a novými trendy terapie spojené s pohybem a možnostmi práce s mentálně postiženými. Předmětem práce také bylo zjistit vztah mentálně retardovaných k pohybu, sportu a veškerým pohybovým aktivitám, jak pohyb oni sami vnímají, zda je pro ně prospěšný, zda má nějaký vliv na fyzický a psychický vývoj těchto jedinců a vliv na léčbu a udržování určitého stupně psychomotorického vývoje. Metoda: Průzkum byl proveden v ÚSP v Brandýse nad Labem u dvanácti klientů s rozdílným stupněm mentální retardace, kteří byli vybráni na základě konzultace s vychovateli a rodiči, analýzy jejich dokumentace (psychologické, lékařské vyšetření) a mou zkušeností při práci s mm1. Metoda průzkumu byla provedena formou strukturovaného rozhovoru s klienty. Výsledky jsem následně zhodnotil na konci práce. Výsledky: Z vyhodnocení dat,...
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