Imunitní odpověď myší proti ptačím schistosomám: od lokálního k systémovému pohledu

Majer, Martin

In the host bodies, helminths often undergo complicated migrations that afflict various organs. Defining the immune response is then usually focused only on isolated spatio-temporal fragments but lacks the whole-body context. To broaden the knowledge about the tissue-specific and systemic immune response, this thesis focused on mice infected with two model species of avian schistosomes of the genus Trichobilharzia. T. regenti penetrates the skin and enters the spinal cord within a few days. Most of the parasites die in the skin which is accompanied by an influx of leukocytes. We confirmed that it was partially mirrored also in skin draining lymph nodes by increasing the T helper 2 cells proportion. Interestingly, there were reduced numbers of T cells in the spleen with an increased proportion of the regulatory T cells. Therefore, we conclude that adaptive systemic response differed and the regulatory phenotype dominated. However, the skin phase-induced eosinophilia in blood influenced the milieu of the central nervous system (CNS). Schistosomula which entered the spinal cord triggered inflammation and enhanced expression of eotaxins, which attracted the eosinophils from the blood into the CNS. The antigen-presenting cells contribute to the communication of CNS with the periphery. We employed and...

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