National Repository of Grey Literature 14 records found  1 - 10next  jump to record: Search took 0.00 seconds. 
The role of mitochondria in the pathogenesis of Huntington's disease
Řeháková, Kateřina ; Hansíková, Hana (advisor) ; Marková, Michaela (referee)
Huntington's disease is a neurodegenerative disease affecting the nervous system. It is caused by the mutation of the huntingtin protein coding gene. The mutation is manifested by the multiplication of CAG triplets. Huntingtin is present more in the cytoplasm. It interacts with many proteins and has roles also in transcription and cell transport. Huntingtin also participates in correct regulation of embryonic development and development of nerve tissue. Mutant huntingtin causes oxidative stress, mitochondrial biogenesis and OXPHOS disorders. Diagnosis of Huntington's disease is based on a laboratory examination of the presence of an allele predisposing to the disease. Clinical imaging is also an important part of diagnostics. The patient exhibits uncontrollable choreatic body movements and dementia. The aim of the thesis was to describe the main characteristics of Huntington's disease with the focus of HD on mitochondrial energy metabolism. In the practical part, the aim was to analyze mitochondrial respiration by high resolution polarography in a set of 3 fibroblast lines from patients with Huntington's disease. Polarographic analyses showed that respiration of HD fibroblasts was decreased in comparison with controls. We found that complex II of oxidative phosphorylation was most affected in HD...
The effect of heating and ventilation on the prevalence of allergies in children
Marková, Michaela ; Jílek, Petr (advisor) ; Kudláčková, Zděnka (referee)
Author: Michaela Marková Title: The effect of heating and ventilation on the prevalence of allergies in children Diploma work Charles University in Prague, Faculty of Pharmacy in Hradec Králové Study program: Pharmacy BACKGROUND: We investigated the protective or risk effects of different ways of heating and ventilation on the prevalence of allergies and their symptoms in children. We found available scientific literature with relation to our theme and compared their and our results. METHODS: We sent 2793 questionnaires to 69 elementary schools in the Czech Republic. The questionnaires were retrospectively filled in by parents of children from seventh or eighth grade of elementary school. We got back 1697 questionnaires which were statistically evaluated. We focused on the part with the questions about heating and ventilation of children's bedrooms. RESULTS: Some results have statistical significance. Using central heating in children's bedrooms of 4 and 5-year-old children and gas heating in bedrooms of 6-year-old and older children has adverse effect on the prevalence of allergies. Heating with solid fuels was the risk factor for asthma in children up to the age of 3 years and for eczema in children over the age of 6 years. Floor heating has adverse effect on the prevalence of eczema in 4 and...
Expression of selected defects of oxidative phosphorylation system in cultivated fibroblasts
Marková, Michaela ; Hansíková, Hana (advisor) ; Kalous, Martin (referee)
AAbbssttrraacctt:: The mammalian organism is entirely dependent on ATP production by oxidative phosphorylation system (OXPHOS) on the inner mitochondrial membrane. OXPHOS is composed of respiratory chain complexes I-IV, ATP synthase and also include two electron transporters cytochrome c and coenzyme Q. Disorders of mitochondrial energy metabolism caused by OXPHOS defects are characterized by extreme heterogeneity of clinical symptoms, variability of tissues affected and the severity of the defect at the level of individual tissues. The mitochondrial disorders are not always clearly expressed at the level of available tissue or most easily available cultured fibroblasts and/or currently available methods are not capable to detect the defects on the fibroblasts level. The aim of this master thesis was to identify by biochemical methods, especially by high sensitive polarography, OXPHOS disorders in cultured fibroblasts. Cell lines from 10 patients with isolated (SURF21, SCO1 ND1, ND5) or combined defects of OXPHOS complexes whose biochemical defect was confirmed in muscle tissue as well as 14 patients with non- mitochondrial diseases (8 patients with Huntington disease, 6 patients with disorder of sulphur amino acids metabolism) were analysed. Furthermore impact of various cultivation conditions on OXPHOS...
Mer1 and Nam8 in splicing regulation
Marková, Michaela ; Abrhámová, Kateřina (advisor) ; Stejskalová, Eva (referee)
By the mutual cooperation, Mer1 nad Nam8 proteins activate pre-mRNA splicing of four specific genes: AMA1, MER2, MER3 and SPO22, that are required for meiotic recombination and nuclear division. Expression of these genes does not change during the cell cycle, nevertheless, the efficient splicing of their pre-mRNA occures only during meiosis because Mer1 protein, which facilitates their splicing, is expressed only in meiotic cells. All these pre-mRNAs contain nonconsensual 5'splice site (5'ss) which is less recognizable for the spliceosomal subunit U1 snRNP in comparison with the consensual sequence. There is an enhancer area near to 5'ss on the pre-mRNA of this genes that serves as a binding site for Mer1p which makes recruitment of U1 snRNP more efficient. Mer1p cooperate via other proteins with Nam8p. Protein Nam8, a part of U1 sn RNP, is bound on pre-mRNA downstream from 5'ss close to the enhancer area. Mer1p in cooparation with Nam8p facilitates spliceosome assembly on the nonconsensual 5'ss and subsequently pre-mRNA splicing.
The Proposal for Improvement Economy of Municipality
Marková, Michaela ; Vendolský, Ondřej (referee) ; Lajtkepová, Eva (advisor)
Bachelor´s thesis named „The Proposal for Improvement Economy of Municipality“ deals with the municipality economy of city Slavkov u Brna between years 2006 – 2008. The aim of this work is to analyses revenues and expenditures and to evaluate the municipality economy. The first part of the work is focused on the theoretical explanations, the second part of the work is focused on evaluation of management in municipality of city Slavkov u Brna and third part includes the proposal for improvement economy of this municipality.
Evaluation of the Financial Situation of a Company
Marková, Michaela ; Holásková, Lenka (referee) ; Kocmanová, Alena (advisor)
The aim of this diploma thesis is to evaluate the financial efficiency of company Daikin Device Czech Republic for the period betwen years 2006 – 2009. By using the methods of financial analyses I evaluate the current situation and propose suggestion for improvement. The first part is theoretical and explains all related terms and sources that are later used in practical part. The practical part of the thesis starts with analysis of outside and inside factors, and subsequently is followed by the evaluation of the financial indicators and financial efficiency and the summary. In final part of this work I suggest some proposals that could lead to the improvement of the current situation of the company.
Prague Castle fire protection
Laštůvka, Jaromír ; Rosická, Zdena (referee) ; Marková, Michaela (advisor)
My bachelor’s thesis „Security of the Prague Castle and its protection against fire“ concentrates just on a small part of complex problems of fire service. It concerns the methods of securing a historic building both from the point of view of a possible risk of fire and from the point of view of evacuating a large number of people from the whole Prague Castle compound.
Double Tax Treaties
Procházková, Andrea ; Černohlávková, Eva (advisor) ; Marková, Michaela (referee)
The thesis deals with issue of international double taxation with respect to taxes on income and capital. The aim of the thesis is to provide a comprehensive overview of the issue of concluding international double tax treaties and to verify, whether the differences in their provisions can be significant enough to affect activities of internationally active entities. The body of the thesis is divided into three chapters. The first chapter explains what double taxation is, how it occurs and the possible ways of its elimination. It also deals with related tax evasion. The second chapter is devoted to bilateral and multilateral tax treates. The emphasis is on OECD and UN model conventions and related issues of exchange of information, non-discrimination and dispute resolution. The third chapter focuses on the approach of the Czech republic to enter into tax treaties. Its main part is devoted to a comparison of tax treaties which the Czech republic has concluded with the United States of America, Slovakia and Germany.
Selected Tax Aspects of International Business
Tichá, Dominika ; Černohlávková, Eva (advisor) ; Marková, Michaela (referee)
The result of the global integration of the world economy are globally operating corporations. Multinational enterprises operate in different countries whose economic policies are different from each other. These differences have considerable impact on tax policy. Taxes are the subject of conflicting interests of the international business and tax policy. One of the current objectives of the MNEs is to reduce the total cost in order to achieving competitive advantage in the global market as well as to minimize the global tax liability through its optimization. To achieve these objectives the international tax planning is a widely used means. International tax planning uses tax havens and their favourable tax conditions to divert profits. Minimizing tax liability often leads to tax avoidance or tax evasion. Different legislative adjustments and mutual meeting of local and international legislation gradually uncover gaps and weaknesses enabling reduction and shedding of profits. Consequently, states are deprived of significant tax revenue. One of the most common and most important methods to minimize the tax liability of MNEs is transfer pricing. Transfer prices are to be determined in accordance with the arm's length principle, using comparative analysis and an appropriate method of assessment. Transactions carried out between associated enterprises may be regarded as a risk area which gets to the fore states and tax administrations. The first part of thesis focuses on tax policy in terms of international taxation of income and international tax planning. The second part presents a transfer pricing. The third and last part describes the practices of MNEs in transfer pricing and corresponding initiatives of national and international organizations.
Tangible fixed assets in terms of accounting and tax
MARKOVÁ, Michaela
The goal of bachelor's thesis is to analyse the long-term tangible assets from both accounting and fiscal view, to compare individual aspects from the impact on the corporate income tax view and to appraise the given situation in the selected accounting entity. The theoretical part treats the approximation of the differences between the accounting and fiscal view on the long-term tangible assets. It deals with the defining of the long-term tangible assets, technical appraisal and the depreciation methods from both views as well. Its part is also addicted to the dilemma of the acquisition, the appraisal and the consequential retirement of the long-term tangible assets. Last but not least it points to the differences of the accounting and tax depreciation and to the impact on the income tax base. The practical part is focused on the analyse execution of the accounting and tax deprecitation of the long-term tangible assets in the selected corporate. The content of the analyse is to show the depreciation impact on the income tax base and the consequential analysis. Furhtermore the practical part is addicted to the dilemma of the technical appreciation and the appropriate potentiality that may occur in terms of the long-term tangible assets depreciation of the given accounting entity. Likewise it contains the analyse of the accounting and tax methods, the consequential appraisal and the summary. Not least it deals with the latest methods of the long-term tangible assets retirement.

National Repository of Grey Literature : 14 records found   1 - 10next  jump to record:
See also: similar author names
5 MARKOVÁ, Magdalena
5 MARKOVÁ, Marcela
7 MARKOVÁ, Marie
6 MARKOVÁ, Markéta
7 MARKOVÁ, Martina
11 MARKOVÁ, Michaela
1 MARKOVÁ, Michala
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6 MARKOVÁ, Monika
5 Marková, Magdaléna
5 Marková, Marcela
7 Marková, Marie
6 Marková, Markéta
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