Název: Development of Continuous Technology for the Preparation of Pharmaceuticals
Autoři: Jaklová, Natalie
Typ dokumentu: Příspěvky z konference
Konference/Akce: Bažant Postgraduate Conference 2024, Prague (CZ), 20240605
Rok: 2024
Jazyk: eng
Abstrakt: The present research focuses on the transition of a batch reaction assisted by phase transfer catalyst (PTC) into continuous process. The first reaction studied was an N-alkylation reaction with methyl ester of the 1-methyl-10α-methoxydihydrolysergic acid (MeLUME) as product. MeLUME is one of the intermediates in synthesis of drug Nicergoline. The N-alkylation occurs in two different immiscible phases and the bridge between these phases is the phase transfer catalyst. The study was performed in several different continuous flow apparatuses. The best results were obtained in a capillary reactor, with assistance of ultrasound.
Klíčová slova: continualization; pharmaceuticals; ultrasound
Zdrojový dokument: Proceedings of Abstracts, ISBN 978-80-86186-32-0
Práva: Dílo je chráněno podle autorského zákona č. 121/2000 Sb.

Instituce: Ústav chemických procesů AV ČR (web)
Původní záznam: https://hdl.handle.net/11104/0354017

Trvalý odkaz NUŠL: http://www.nusl.cz/ntk/nusl-616428