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Original title:
Development of Continuous Technology for the Preparation of Pharmaceuticals
Authors: Jaklová, Natalie
Document type: Papers
Conference/Event: Bažant Postgraduate Conference 2024, Prague (CZ), 20240605
Year: 2024
Language: eng
Abstract: The present research focuses on the transition of a batch reaction assisted by phase transfer catalyst (PTC) into continuous process. The first reaction studied was an N-alkylation reaction with methyl ester of the 1-methyl-10α-methoxydihydrolysergic acid (MeLUME) as product. MeLUME is one of the intermediates in synthesis of drug Nicergoline. The N-alkylation occurs in two different immiscible phases and the bridge between these phases is the phase transfer catalyst. The study was performed in several different continuous flow apparatuses. The best results were obtained in a capillary reactor, with assistance of ultrasound.
Keywords: continualization; pharmaceuticals; ultrasound
Host item entry: Proceedings of Abstracts, ISBN 978-80-86186-32-0
Rights: This work is protected under the Copyright Act No. 121/2000 Coll.
Institution: Institute of Chemical Process Fundamentals AS ČR (web)
Original record: https://hdl.handle.net/11104/0354017
Permalink: http://www.nusl.cz/ntk/nusl-616428
The record appears in these collections:
Research > Institutes ASCR > Institute of Chemical Process Fundamentals
Conference materials > Papers
Authors: Jaklová, Natalie
Document type: Papers
Conference/Event: Bažant Postgraduate Conference 2024, Prague (CZ), 20240605
Year: 2024
Language: eng
Abstract: The present research focuses on the transition of a batch reaction assisted by phase transfer catalyst (PTC) into continuous process. The first reaction studied was an N-alkylation reaction with methyl ester of the 1-methyl-10α-methoxydihydrolysergic acid (MeLUME) as product. MeLUME is one of the intermediates in synthesis of drug Nicergoline. The N-alkylation occurs in two different immiscible phases and the bridge between these phases is the phase transfer catalyst. The study was performed in several different continuous flow apparatuses. The best results were obtained in a capillary reactor, with assistance of ultrasound.
Keywords: continualization; pharmaceuticals; ultrasound
Host item entry: Proceedings of Abstracts, ISBN 978-80-86186-32-0
Rights: This work is protected under the Copyright Act No. 121/2000 Coll.
Institution: Institute of Chemical Process Fundamentals AS ČR (web)
Original record: https://hdl.handle.net/11104/0354017
Permalink: http://www.nusl.cz/ntk/nusl-616428
The record appears in these collections:
Research > Institutes ASCR > Institute of Chemical Process Fundamentals
Conference materials > Papers
Record created 2024-06-15, last modified 2024-06-15
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