Název:
Interaction of tick-borne encephalitis virus with host and vector cells
Autoři:
TYKALOVÁ, Hana Typ dokumentu: Disertační práce
Rok:
2022
Jazyk:
eng
Abstrakt: The proposed thesis deals with the various aspects of tick-borne encephalitis virus infection in the host and the vector on the cellular level. It uncovers transcriptomic and proteomic responses in infected cells in the human neurons and astrocytes, and vector cells. It identifies the subgenomic flaviviral RNA as an important pathogenesis effector that can interfere with the vector RNAi pathway, and at the same time denotes the components of this pathway. It also describes the phenomenon of impairment of host protein and rRNA synthesis upon TBEV infection. Moreover, it uncovers the importance of quasispecies in the adaptation to vector and host cells.
Klíčová slova:
immune response; neural cells; proteomics; quasispecies; RNAi pathway; tick cells; tick-borne encephalitis virus; transcriptional shut-off; transcriptomic; translational shut-off Citace: TYKALOVÁ, Hana. Interaction of tick-borne encephalitis virus with host and vector cells. České Budějovice, 2022. disertační práce (Ph.D.). JIHOČESKÁ UNIVERZITA V ČESKÝCH BUDĚJOVICÍCH. Přírodovědecká fakulta
Instituce: Jihočeská univerzita v Českých Budějovicích
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Informace o dostupnosti dokumentu:
Plný text je dostupný v digitálním repozitáři JČU. Původní záznam: http://www.jcu.cz/vskp/17425