Original title: Interaction of tick-borne encephalitis virus with host and vector cells
Authors: TYKALOVÁ, Hana
Document type: Doctoral theses
Year: 2022
Language: eng
Abstract: The proposed thesis deals with the various aspects of tick-borne encephalitis virus infection in the host and the vector on the cellular level. It uncovers transcriptomic and proteomic responses in infected cells in the human neurons and astrocytes, and vector cells. It identifies the subgenomic flaviviral RNA as an important pathogenesis effector that can interfere with the vector RNAi pathway, and at the same time denotes the components of this pathway. It also describes the phenomenon of impairment of host protein and rRNA synthesis upon TBEV infection. Moreover, it uncovers the importance of quasispecies in the adaptation to vector and host cells.
Keywords: immune response; neural cells; proteomics; quasispecies; RNAi pathway; tick cells; tick-borne encephalitis virus; transcriptional shut-off; transcriptomic; translational shut-off
Citation: TYKALOVÁ, Hana. Interaction of tick-borne encephalitis virus with host and vector cells. České Budějovice, 2022. disertační práce (Ph.D.). JIHOČESKÁ UNIVERZITA V ČESKÝCH BUDĚJOVICÍCH. Přírodovědecká fakulta

Institution: University of South Bohemia in České Budějovice (web)
Document availability information: Fulltext is available in the Digital Repository of University of South Bohemia.
Original record: http://www.jcu.cz/vskp/17425

Permalink: http://www.nusl.cz/ntk/nusl-513375


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Universities and colleges > Public universities > University of South Bohemia in České Budějovice
Academic theses (ETDs) > Doctoral theses