Národní úložiště šedé literatury Nalezeno 3 záznamů.  Hledání trvalo 0.01 vteřin. 
Interaction of tick-borne encephalitis virus with host and vector cells
TYKALOVÁ, Hana
The proposed thesis deals with the various aspects of tick-borne encephalitis virus infection in the host and the vector on the cellular level. It uncovers transcriptomic and proteomic responses in infected cells in the human neurons and astrocytes, and vector cells. It identifies the subgenomic flaviviral RNA as an important pathogenesis effector that can interfere with the vector RNAi pathway, and at the same time denotes the components of this pathway. It also describes the phenomenon of impairment of host protein and rRNA synthesis upon TBEV infection. Moreover, it uncovers the importance of quasispecies in the adaptation to vector and host cells.
Změny globální genové exprese v lidských neurálních buňkách po infekci virem klíšťové encefalitidy
TYKALOVÁ, Hana
Our study was focused on the effect of tick-borne encephalitis virus infection on global gene expression in two human neural cell lines (neuroblastoma and glioblastoma). Changes of gene expression were determined using microarray approach. We identified several genes with up-or down-regulated expression in neural cells following the infection. The changes in expression of some of them were similar in both cell lines,other exhibited different pattern.
Vliv extraktů ze slinných žláz (SGE) a slin klíštěte \kur{Ixodes ricinus} na replikaci viru klíšťové encefalitidy v podmínkách \kur{in vitro}
TYKALOVÁ, Hana
We examined the influence of saliva and SGE from Ixodes ricinus tick, the main European TBEV vector, on the replication of TBEV under in vitro conditions in various mammalian cell lines (fibroblasts, macrophages, porcine kidney). In addition, the effect of tick saliva on the production of IFN {$\beta$} by fibroblast cells was studied.

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