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Communication SW ARION
Kaczmarczyk, Václav ; Kašík, Petr (referee) ; Zezulka, František (advisor)
The main goal of this thesis is creating diagnostic software for analyse communication via protocol ARION. That software would record and store communication data which can be analyzed late and also allows direct communication analysis in real time. Except that there will be visualization functions, for effective representation of data (stored or real-time recorded). This software can be used either by net developers or by end-users like easy visualization software. Next point is describing communication protocol ARION and create developer’s handbook. The practical part of this thesis consists of two points. The first one is developing simple device which allows communicating via protocol ARION. In second communication firmware for that device is written and tested.
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Experimental models of increased physical activity for cardiovascular research
Ševčíková, Anežka ; Kolář, František (advisor) ; Kašík, Petr (referee)
This thesis provides a critical review of experimental models and protocols of increased physical activity that have been used for various purposes in cardiovascular research in small laboratory rodents. The thesis describes their physiological and pathophysiological effects and evaluates the advantages and disadvantages of using each model to study the adaptive mechanisms and beneficial effects of physical activity on cardiovascular disease. The use of physical activity in cardiovascular patients or people with cardiovascular risk factors is also mentioned. A review of exercise stress tests used to detect the degree of experimental heart failure of various etiologies and specific examples are also included. Key words physical activity, endurance training, stress test, small laboratory animals, heart, hypertrophy, therapeutic effects
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Pharmacotherapy in the treatment of opioid addiction
Bodinková, Jolana ; Novotný, Jiří (advisor) ; Kašík, Petr (referee)
Opiate addiction represents a difficult problem, both medically and socially. With millions of affected people, either by such kinds of addiction or its side effects, across the globe, the condition requires its resolution to be effective, which can be provided by opioid pharmacotherapy, either methadone-, buprenorphine- or naloxone-based. In regard to increasing numbers of not only cases but also deaths, related to drug overdose, opiate addiction treatments still remain underused in medical settings. This thesis summarizes pharmacotherapy practices used during opioid use disorder treatments. Its main part predominantly focuses on the description of therapeutical procedures, their advantages, and deficiencies. Keywords: opioid abuse, pharmacotherapy, methadone, buprenorphine, naloxone
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Use of animal models in the study of the mechanisms of subjective tinnitus.
Dittrichová, Jana ; Tureček, Rostislav (advisor) ; Kašík, Petr (referee)
Tinnitus, phantom hearing sensation, is one of the major audiological disorders affecting a significant proportion of the human population. However, the mechanisms underlying this condition remain unclear. Animal models represent an important tool in the investigation of the pathogenesis of hearing diseases. The present bachelor thesis reviews the most important findings on the possibilities of detecting tinnitus in laboratory animals, especially rats and mice, its neural correlates in the mammalian auditory system, as well as the risk factors that lead to its development and maintenance. It was found that the most common causes of tinnitus are sensorineural hearing loss induced by exposure of animals to excessive noise or ototoxic agents, as well as their genetic predisposition. These factors cause maladaptive changes in the central auditory pathway that are likely responsible for the chronic course of the disease. The changes found include, in particular, hyperactivity of neurons of the auditory nuclei of the brainstem and increased synchrony in the area of the primary auditory cortex. Using animal models, it was also found that a significant proportion of the observed pathophysiological changes result from attenuated GABAergic inhibition in the auditory pathway. This suggested a direction for...
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The effect of season on mitochondrial swelling of rat heart after cold acclimation
Kašík, Petr ; Horníková, Daniela (advisor) ; Holzerová, Kristýna (referee)
Risk of death from cardiovascular disease is substantially increased throughout winter season and by exposure of organism to acute cold stress. However, several studies have suggested that some cold acclimation models could act cardioprotectively. The thesis is focused on effects of acute and chronic cold acclimation on swelling of rat heart mitochondria. Mitochondrial swelling is, besides other things, caused by massive influx of Ca2+ into the mitochondria especially during ischemia-reperfusion injury. By that, mitochondria permeability transition pore is being opened and subsequently, this could end up in mitochondrial burst and cell death, eventually. Lower rate of mitochondrial swelling indicates greater mitochondrial resistance. The results express higher mitochondrial resistance after acute cold exposure and chronic cold acclimation. Key words: cold, mitochondria, Ca2+ ions, swelling, MPTP, myocardium, ROS, ischemia
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The effect of season on mitochondrial swelling of rat heart after cold acclimation
Kašík, Petr ; Horníková, Daniela (advisor) ; Holzerová, Kristýna (referee)
Risk of death from cardiovascular disease is substantially increased throughout winter season and by exposure of organism to acute cold stress. However, several studies have suggested that some cold acclimation models could act cardioprotectively. The thesis is focused on effects of acute and chronic cold acclimation on swelling of rat heart mitochondria. Mitochondrial swelling is, besides other things, caused by massive influx of Ca2+ into the mitochondria especially during ischemia-reperfusion injury. By that, mitochondria permeability transition pore is being opened and subsequently, this could end up in mitochondrial burst and cell death, eventually. Lower rate of mitochondrial swelling indicates greater mitochondrial resistance. The results express higher mitochondrial resistance after acute cold exposure and chronic cold acclimation. Key words: cold, mitochondria, Ca2+ ions, swelling, MPTP, myocardium, ROS, ischemia
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The effect of curcumin on carcinogenesis and metastasis development
Kašík, Petr ; Kábelová, Adéla (advisor) ; Vališ, Karel (referee)
Curcumin is a polyphenol from the roots of plant Curcuma longa. Highly pleiotropic effect of curcumin has presently application not only in prevention, but also in treatment of various diseases including cancer. Therefore, this bachelor thesis aims to summarize the current knowledge concerning the effect of curcumin on carcinogenesis and metastasis development. Considering the inhibition of cancer cells proliferation, curcumin stops the progression of cell cycle, primarily via regulating the activity of cyclins and cyclin-dependent kinases, their inhibitory proteins or tumor suppressor protein p53. Additionally, p53 also seems to have an important role in the initiation of intrinsic apoptotic pathway, which was observed in many cancer cell lines after curcumin administration. Apoptotic proteins involved in apoptosis induction after curcumin application also comprise Bcl-2 family proteins and, caspases. Other mechanisms exerted by which curcumin prevent cancer development include suppression of angiogenesis, increase of oxidative stress or modulation of inflammatory response. Finally, curcumin also suppress cancer cells invasion and migration by enhancing the transcription of E- cadherin and decreasing of the transcription of matrix metalloproteinases. Because the application of curcumin in clinical...
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Communication SW ARION
Kaczmarczyk, Václav ; Kašík, Petr (referee) ; Zezulka, František (advisor)
The main goal of this thesis is creating diagnostic software for analyse communication via protocol ARION. That software would record and store communication data which can be analyzed late and also allows direct communication analysis in real time. Except that there will be visualization functions, for effective representation of data (stored or real-time recorded). This software can be used either by net developers or by end-users like easy visualization software. Next point is describing communication protocol ARION and create developer’s handbook. The practical part of this thesis consists of two points. The first one is developing simple device which allows communicating via protocol ARION. In second communication firmware for that device is written and tested.
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