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Do public R&D subsidies boost competitiveness of supported companies in the Czech Republic?
Horák, Petr ; Teplý, Petr (advisor) ; Švarcová, Natálie (referee)
The purpose of this thesis is to investigate the impact of government non-investment and applied R&D subsidies on the firm level competitiveness. According to many literature sources the indicators of competitiveness are assumed to be Return on Assets, Return on Equity, Return on Sales and Asset Turnover ratio. The tool used to test the effect is counterfactual analysis. The subsidized companies are compared to a control group drawn by Propensity Score Matching, the effect is tested by Average Treatment Effect on the Treated and the difference in size of other financials is derived by Difference in Differences. The study focuses on two industries NACE C25 (metallurgy) and C28 (manufacture of machines). The subsidized companies show no added significant growth of competitiveness whatsoever. The financials (Total Assets, Equity, Turnover) grew, compared to the control group, only for industry C25. JEL Classification O31, O38, H21 Keywords R&D, Innovation, non-investment, subsidies, applied R&D, competitiveness Author's e-mail petr.rotr@post.cz Supervisor's e-mail petr.teply@fsv.cuni.cz
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Cathepsins B of the bird schistosome, Trichobilharzia regenti
Dolečková, Kateřina ; Horák, Petr (advisor) ; Grevelding, Christoph (referee) ; Horn, Martin (referee)
1. Overview Schistosomes have achieved first position among parasitic helminths, because some of them are the etiological agents of a serious human parasitic disease, schistosomiasis, which affects over 200 million people in tropical and subtropical countries (WHO, 2001). Other schistosomatids, such as the bird flukes of the genus Trichobilharzia, have also implications for human health. Although they can mature only in specific hosts (birds), their invasive larvae - cercariae - are able to penetrate also human skin due to chemical signals similar to those present on bird skin (Haas and van de Roemer 1998). Repeated infections result in an inflammatory reaction of the skin called cercarial dermatitis. Due to the increasing number of outbreaks all around the world, cercarial dermatitis is cons disease (Kolářová 2007idered as re-emerging ; Larsen et al. 2004). Among schistosomes, Trichobilharzia regenti is the only species described so far having a unique migration route within vertebrate hosts: after penetration of the skin, the invasive larvae enter peripheral nerves and continue via the spinal cord and central nervous system to the nasal cavity of birds, causing neuromotor disorders or paralyses of birds and even experimental mammals (Hrádková...
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BIRD SCHISTOSOMES: development of schistosomula with focus on Trichobilharzia spp
Chanová, Marta ; Horák, Petr (advisor) ; Špakulová, Marta (referee) ; Haas, Wilfried (referee)
5 ABSTRACT Schistosomulum is the first stage developing in definitive host body, affecting various body parts and in the case of bird schistosomes present in host tissues for longest period. The aims of the present thesis are to summarize recent knowledge of bird schistosomula migration, development and pathogenic impact on host tissues and complete the details for two model species (Trichobilharzia szidati and T. regenti) with different life strategy. The other aim was to introduce and test the method for in vitro cultivation of schistosomula. Schistosomulum is formed by transformation of cercaria in the host skin at the time of penetration. The process is preceded by cercarial tail detachment and includes emptying of penetration glands and extensive surface changes. All this take place also under defined in vitro conditions. Transformed schistosomula migrate towards the target organ in host body. Depending on the species schistosomula migrate via the circulatory system or nervous tissues and the migration is directed either to intestinal or nasal area (visceral or nasal species, respectively). Specific migratory pattern for lung passage of T. szidati and migratory route of T. regenti through the nervous system, unique among schistosomes and including intra- and extra vascular location, are obligatory for...
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The use of LC/MS for the Study of Biotransformation of Xenobiotics in Helminths
Vokřál, Ivan ; Szotáková, Barbora (advisor) ; Lísa, Miroslav (referee) ; Horák, Petr (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Candidate Mgr. Ivan Vokřál Supervisor Doc. Ing. Barbora Szotáková, Ph.D. Title of Doctoral Thesis The use of LC/MS for the study of biotransformation of xenobiotics in helminths Annually, parasites cause many losses regarding not only human lives but also the livestock. One of the most effective weapons that can be used against them are anthelmintics. However, in many cases anthelmintics cease to work and resistance development occurs. One of the possible mechanisms of resistance is the biotransformation of the drug to ineffective or less active products by the parasite. The aim of this work was to bring new knowledge about the biotransformation of drugs in helminths. Emphasis was given to the relationship between biotransformation and the resistance of parasites against anthelmintic drugs. A possible technique to achieve this goal is to study directly the products of biotransformation, i.e. metabolites. As this issue is nowadays most frequently solved by liquid chromatography and mass spectrometry, we used this technique to meet our goals. Biotransformation was studied in representatives of tapeworms, flukes and roundworms. Where possible, economically important representatives as Barber's pole...
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Environmentally advanced retirement home
Voves, Martin ; Rubinová, Olga (referee) ; Horák, Petr (advisor)
The subject of my master's thesis is the design of an energy-efficient house for the elderly. The building has three floors. The construction system is made of ceramic blocks filled with glass wool. The building is covered with a flat vegetation roof. The retirement home has 15 apartments, a doctor's office, a common dining area, a common room and offices for administration. A technical concept for the building environment was designed for the building. The dining room, office, lounge and doctor's rooms are forcibly ventilated. The premises are divided into three zones and each zone has its own air handling unit. Heating is provided by two condensing gas boilers and the whole building is heated by radiators. An assessment was made for the design of photovoltaic panels. In the third part, an assessment and research of sources for heating and hot water was prepared.
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Low-energy building of kindergarten in Polerady
Pflieglerová, Karolína ; Horák, Petr (referee) ; Počinková, Marcela (advisor)
The aim of this thesis is to create project documentation for a low-energy kindergarten in Polerady. The building has one floor with a flat green roof. The layout of the kindergarten is divided into two units, which contain two classes with facilities. The thesis consists of three parts. Part A consists of documentation for the building permission. The kindergarten is designed for 30 children and is divided into two units. Part B consists of the design of building services. The building uses LED lighting, mechanical ventilation with heat recovery, two heat pumps are designed for heating, which are connected to floor heating and hot water tank, on the roof of the building there are 30 photovoltaic panels. The energy produced from the panels is consumed by all appliances in the building. Part C, after creating another building energy performance certificate, compares two types of heat source. The floor heating scheme is created by calculating the heat losses of the rooms, using the DekSoft program.
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Environmentally advanced building - for sports activities
Krahula, Tomáš ; Horká, Lucie (referee) ; Horák, Petr (advisor)
The task of the master project is to design a building for sports activities in Sehradice, Zlín region. First the documentation was elaborated, the second part HVAC was designed and the last part focussed on daylighting. The building has one floor and flat green roof. The building includes a fitness, a yoga room, a relax room, two saunas, changing rooms and staff room. The superstructure is designed using Heluz ceramic block walls and Spiroll panel floor structure. Façade is insulated with ETICS. HVAC is provided by two gas boilers, two mechanical ventilation units (indoors) and a cooling unit (outdoor). Domestic hot water is provided by the gas boiler and solar panels. The building uses LED lights. Electricity consumption is partially covered by photovoltaics on the roof. The building plot also includes a large carpark in front of the building. The designs were elaborated in Revit, AutoCAD and energy assessment in Deksoft software.
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Heating of an apartment building using renewable energy sources
Kováčová, Nour ; Vyhlídalová, Karolína (referee) ; Horák, Petr (advisor)
Diplomová práce je rozdělena na tří částí. První částí je analýza tématu, cílů a způsobů řešení, která obsahuje i teoretickou část. Druhá část je aplikace tématu na řešeném objektu včetně podrobného výpočtu a návrhu otopné soustavy, přípravy teplé vody, dvou variant alternativních zdrojů tepla a jejich porovnání, které vede k výběru lepšího zdroje tepla. Třetí část je projekt a obsahuje technickou zprávu vybrané varianty a projektovou dokumentaci, která obsahuje všechny potřebné výkresy.
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Energy performance of a civic building
Kořenková, Veronika ; Horká, Lucie (referee) ; Horák, Petr (advisor)
The goal of this thesis is to process three variants of energy performance certificate of the building with different heat sources. The building is in mountain area Bílá in Frýdek-Místek region. The thesis has three parts. First part is focused on literary research of heat pumps. Second, calculation part, describes three proposed heat source solution. First heat source is heat pump, second is pellet boiler and the last one is gas condensing boiler. All three variants are evaluated from the economic and ecological perspective. Last part of the thesis contains three energy performance certificates of the examined building.
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Heat sources for an apartment building
Jurčík, Peter ; Horák, Petr (referee) ; Vyhlídalová, Karolína (advisor)
This master thesis deals with the design of a heat source for heating and DHW in an apartment building. The theoretical part contains a brief division of heat sources for an apartment building and introduction of the components of the solar system. Significant part si devoted to the T*sol software, which was used as a simulation tool for calculation of the solar system parameters. Finally, an article that addresses similar design of the solar system was analyzed. The calculation part deals with the design of the heating system. It consists of the calculation of heat losses, the design of heating elements, heat source and other components. DHW calculation is solved in two variants – var. 1 with gas condensing boiler and var. 2 with gas condensing boiler and solar system. The last part of the master thesis is dedicated to the design of a solar system for DHW using the simulation of several variants followed by selection of the optimal solution.
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