Original title: Katepsiny B ptačí schistosomy Trichobilharzia regenti
Translated title: Cathepsins B of the bird schistosome, Trichobilharzia regenti
Authors: Dolečková, Kateřina ; Horák, Petr (advisor) ; Grevelding, Christoph (referee) ; Horn, Martin (referee)
Document type: Doctoral theses
Year: 2010
Language: eng
Abstract: 1. Overview Schistosomes have achieved first position among parasitic helminths, because some of them are the etiological agents of a serious human parasitic disease, schistosomiasis, which affects over 200 million people in tropical and subtropical countries (WHO, 2001). Other schistosomatids, such as the bird flukes of the genus Trichobilharzia, have also implications for human health. Although they can mature only in specific hosts (birds), their invasive larvae - cercariae - are able to penetrate also human skin due to chemical signals similar to those present on bird skin (Haas and van de Roemer 1998). Repeated infections result in an inflammatory reaction of the skin called cercarial dermatitis. Due to the increasing number of outbreaks all around the world, cercarial dermatitis is cons disease (Kolářová 2007idered as re-emerging ; Larsen et al. 2004). Among schistosomes, Trichobilharzia regenti is the only species described so far having a unique migration route within vertebrate hosts: after penetration of the skin, the invasive larvae enter peripheral nerves and continue via the spinal cord and central nervous system to the nasal cavity of birds, causing neuromotor disorders or paralyses of birds and even experimental mammals (Hrádková...
Keywords: cathepsin; parasite; peptidase; schistosomes; Trematoda; katepsin; parazit; peptidáza; schistosomy; Trematoda

Institution: Charles University Faculties (theses) (web)
Document availability information: Available in the Charles University Digital Repository.
Original record: http://hdl.handle.net/20.500.11956/26215

Permalink: http://www.nusl.cz/ntk/nusl-465053


The record appears in these collections:
Universities and colleges > Public universities > Charles University > Charles University Faculties (theses)
Academic theses (ETDs) > Doctoral theses