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Synthesis of pyrazino[2,3-b]pyrazines - azaphthalocyanine precursors
Šebl, René ; Zimčík, Petr (advisor) ; Holas, Ondřej (referee)
CHARLES UNIVERSITY IN PRAGUE FACULTY OF PHARMACY IN HRADEC KRÁLOVÉ DEPARTMENT OF PHARMACEUTICAL CHEMISTRY AND DRUG CONTROL Name: René Šebl Supervisor: Doc. PharmDr. Petr Zimčík,Ph.D Title of the thesis: Synthesis of pyrazino[2,3-b]pyrazines - azaphthalocyanine precursors The topic of my thesis was synthesis of azaphtalocyanines containing pyrazinopyrazine units. These molecules have been published only in few publication till now. Since these molecules are extended by one pyrazine nucleuson each unit, their extended conjugation leads to an increased absorption in the higher regions of the absorption spectrum. In the first step, I focused on the synthesis of precursors for subsequent cyclotetramerization. Starting compound for the preparation of various precursors was 6,7- dichloropyrazino [2,3-b] pyrazine-2,3-dicarbonitrile. It underwent nucleophilic substitution leading to products substituted with various substiuents attached via heteroatoms such as oxygen or nitrogen. Another option is the condensation of 5,6-diaminopyrazine-2,3- dicarbonitrile with appropriate diketon. This attempt did not lead to the successful preparation of the precursor. The precursors were subsequently cyclotetramerized to corresponding macrocycles. We succeeded only with one precursor...
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Synthesis of Lanthanidocene Based Compounds
Pospíšek, Marek ; Zmrzlý, Martin (referee) ; Richtera, Lukáš (advisor)
The aim of this bachelor thesis is to summarize the issues of the polymerization catalytic systems based on lanthanidocene complexes. These complexes are subsequently divided by the structure into four basic groups. One part of this work deals with an overview of the most interesting results of the catalytic systems, which are then analyzed and assessed either in its entirety or point of view of catalytic activity, living mechanism of polymerisation and stereo or regioselectivity. The focus is also placed on type of monomers or the conditions of polymerization. In this part of thesis are also described general methods for their synthesis. Found analogies and generalization are commented from the point of view of the design of the catalytic systems for the purpose of choosing the stereo or regioselectivity, molar mass and its distribution. This gives significance to these complexes as catalytic systems for obtaining the required polymer properties. The acquired knowledge is used for the theoretical design of the catalytic system for controlled polymerization.
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Synthesis of colloidal gold nanorods for biomedical applications
Valkovičová, Jiřina ; Bernard, Vladan (referee) ; Drbohlavová, Jana (advisor)
Diplomová práce se zabývá výrobou a využitím zlatých koloidních nanotyčinek v biomedicínských aplikacích. Konkrétně se zaměřuje na tři základní funkce nanočástic v analýze - transportní, separační a především zobrazovací. V části o využití nanočástic pro zobrazování je hlavní zájem věnován zejména povrchové plazmonové rezonanci zlatých nantyčinek. Dále je práce zaměřena na využití nanotyčinek pro termální terapii. Následující část je věnována vhodným modifikacím povrchu, hlavně za účelem zmírnění toxicity částic. Závěrem teoretické části jsou způsoby přípravy zlatých koloidních nanotyčinek a techniky jejich následné analýzy. V navazující experimetální části jsou uvedeny postupy, podmínky a výsledky provedených pokusů.
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Company Silektro s.r.o. business assessment
Bezděková, Lucie ; Boukal, Petr (advisor) ; Kučerová, Jana (referee)
This Master's Thesis aims to assess overall financial health of the company Silektro s.r.o. and makro and micro surroundings components influence to its business. Firstly, theoretical basis and selected procedures are described. In practical part, individual methods combining internal and external analyses are applied. The key methods of this thesis are financial analysis, PEST analysis and Porter's Competitive Forces Model. The last used method is synthesis by SWOT. The required outcome is to evaluate analyses used and assessment of the overall business situation in reference period.
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Casinos- economic and social impact in USA
Hodáková, Ľubica ; Běláčková, Vendula (advisor) ; Minárik, Pavol (referee)
Thesis is focused on economic and social impact of the casinos in USA while it is global problem with important economic and political consequences. Main goal of the thesis was to analyze the gambling industry (casinos) in USA from micro-economic view (especially economic and social disadvantages of the casinos with respect to the individuals) and from macro-economic view (especially economic positives with respect to the society) together with social impacts on the citizens. Regarding methods, the thesis used methods of formal logic ( induction, deduction, analysis and synthesis). The thesis has the standard structure -- prologue, core of the thesis conclusion. Theoretical part of the thesis is focused on impacts of the gambling in general, history of the gambling in USA, Indian gaming, actual gambling in USA and legislative framework of the gambling in USA. Analytical part on the other side is focused on positive and negative impact of the commercial casinos and suggested changes in this respect for support of the positive impacts and elimination of the negative ones. Conclusion of the thesis is focused on summary of the most important conclusions of the whole analysis.
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Granular synthesis and its application
Sklenář, André ; URBAN, Ondřej (advisor) ; GUŠTAR, Milan (referee)
This work amis to describe the principles behind granular synthesis, its development history and individual aspects of a granular synthesizer. It aims to familiarize a musician, composer or sound engineer with its details and consolidate the knowledge of a technically knowledgeable music technology user or developer. The work expects the reader to have a basic knowledge of sound physics and its digital representation, aswell as theoretical knowledge of software analysis. The work is divided into two parts. The first part addresses the theoretical properties of granular synthesis and its usage in music history and today. The second part represents a practical example of an application of granular synthesis in the form of a plug-in in several formats and examples of its usage.
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Primární prevence agresivity a násilí na střední odborné škole
Vaňková, Andrea
The bachelor thesis is focused on the primary prevention of aggression and violence in secondary vocational schools. The thesis is divided into two parts -- a theoretical part and a practical part. The aim of the thesis is to define the concept of aggression and violence, classify types of aggression, define the causes of aggression and violence, social aspects associated with aggression, describe the personality traits of aggressor and victim, signals of aggression and violence in the classroom, including prevention education. The method of the theoretical part is the study of professional literature sources, school documents (School Prevention Strategy and the Minimum Preventive Programme), making excerpts and their analysis, synthesis. In the practical part is to find out the awareness of students of primary prevention in relation to aggression and violence at the vocational school. Respondents were pupils of Business Academy and Medical High School in Blansko. The method of questioning is used in the practical part. Data collection instrument was a questionnaire designed for the survey. The data were processed using descriptive statistics and based on the assessment of the state are possible assets designed to improve primary prevention and recommendations for pedagogical practices.
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Zdravý životní styl a stravovací návyky žáků středních škol
Břínková, Marcela
The theoretical part of this work is to define a healthy lifestyle with regard to diet, to describe the food pyramid and nutrients needed for proper development of the pupils. The work also focuses on the school board and the consequences of poor eating habits - obesity, eating disorders. The method is to study the theoretical part of the professional literary sources, creation of excerpts, analysis, synthesis and comparison. The practical part is to carry out a survey among pupils of Secondary School and obtained data to analyze and evaluate. The data are evaluated by simple statistical methods. The objective of exploratory investigation is to determine the awareness of SOS on good eating habits and their attitude towards a healthy lifestyle. The practical part will also assess the functionality of preventive measures against SOŠ unhealthy lifestyle and suggests the possibility of more effective preventive influence on students in healthy lifestyles. The findings are formulated recommendations for practice.
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