|
Complex Cepstrum in Speech Synthesi
Vondra, Martin ; Vích, Robert
In the contribution the use of the complex cepstrum in speech modeling and synthesis is shortly described. The obtained mixed phase parametric speech model is of the finite impulse response type and contains also information about the phase properties of the modeled speech frame. The synthesized speech is more natural, but the memory requirements and numerical complexity are much higher than for minimum phase realization.
Fulltext: content.csg -  PDF
Plný tet: UFE 0356052 - PDF
|
|
Řízení IS/ICT se zaměřením na sourcing služeb informačního systému
Šebesta, Michal ; Voříšek, Jiří (advisor) ; Havlíček, Zdeněk (referee) ; Příklenk, Oldřich (referee) ; Král, Jaroslav (referee)
Research on outsourcing has been around for several decades, while recent evolution in the information systems discipline towards ICT service commoditization significantly changes the context of decision-making. Services that are available on-demand via the Internet allow organizations implementing functions they demand in a fraction of time. This trend represents a chance for organizations seeking to use advanced ICT services without a need of major investments. Problem is the current lack of guidelines and tools for managing ICT services and their outsourcing. Given the trends on the ICT service market, it is expected that much of the IT management in the future will encompass the ICT services and utilize service-level structures. Methods currently available are either too broad or encompass only small part of the whole problem. Ad-hoc or unsound decisions in this area might cause major complications in terms of quality, usability, integration, and consequently influence total cost of organizational IT. Organizations need to either revise existing models or propose and implement completely new models to manage their IS/ICT. This thesis deals with the management of IS/ICT with focus on the ICT services outsourcing. It discusses available sourcing models in the literature and links them to the various interconnected areas. Based on these areas, it presents an integrated view on IT outsourcing strategies. Most importantly the thesis proposes an original concept for decision-making about outsourcing of ICT services named the SOURCER framework. This approach utilizes the presented outsourcing strategies, and introduces a complex methodology and decision-making criteria that will assist organizations with selection of ICT services in order to maintain and manage a most suitable ICT service portfolio. The decision-making is based on four essential viewpoints: function, costs, time, and quality. These viewpoints are discussed, individually analyzed, and serve as a basis for further research. The whole framework is developed and validated according to Design Science Research Methodology (DSRM). Individual components are evaluated using a survey among a group of selected IT managers. Proof of concept is then established by a case study on framework use in a real organization. This case study covers strategy specification, business--IT alignment, specifying service architecture and its interconnections, outsourcing, and management of the ICT service portfolio.
|
| |
|
Hyaluronan ionocomplexes for cosmetic and farmaceutical applications
Cimalová, Jana ; Obruča, Stanislav (referee) ; Pekař, Miloslav (advisor)
This bachelor thesis is focused on the study of a system of cationic surfactant – hyaluronan. Using fluorescent spectroscopy the critical micellar concentration of Carbethopendecinium bromide (Septonex) was determined in three environments – water, 0,15 M NaCl, and buffer PBS, with three fluorescent probes – pyrene, perylene, and nile red. It was found that the physiological environments (buffer and NaCl) reduce the value of CMC about one order. During the experiments with native hyaluronan, precipitate and gel formation were observed. The following part dealt with aggregate behaviour of the new biologically acceptable amphoteric surfactant tetradecylfosfocholine (TPC) in the environment of water and NaCl according to the increasing molar molecular weight of hyaluronan. As a fluorescent probe perylene was used. These measurements showed that the molar molecular weight or a change of ionic force has no effect on the value of CMC and therefore there are no interactions with hyaluronan. The last surfactant to study was 1,2-dihexadecanoyl-3-dimetylammonium-propan (DPTAP), which is water insoluble. DPTAP is soluble in chloroform, but after evaporation of chloroform and after addition of hyaluronan, it precipitated. The results so far, have confirmed that in terms of research of aggregation by fluorescence spectroscopy the new cationic surfactants TPC and DPTAP are not suitable for complexation with hyaluronan.
|
|
Large model simulations in molecular dynamics problems
Pelikán, Vladimír ; Hora, Petr ; Machová, Anna
Molecular dynamics simulation is a well-established techniquefor modelling complex many-particle systems in diverse areas of physics andchemistry. The computational requirements of simulations of large systems,especially when taking into account long-range interactions, are enormous.Two basic tasks in molecular dynamics simulation are surface relaxation andheating. Both of these tasks are studied in this contribution.
|
|
Synthesis of unsymmetrical derivatives of azaphthalocyanines and their complex formation with pyridine
Žižkovská, Jana ; Zimčík, Petr (advisor) ; Miletín, Miroslav (referee)
1. Summary Synthesis of unsymmetrical derivatives of azaphthalocyanines and their complex formation with pyridine Mgr. Jana Žižkovská Department of Pharmaceutical Chemistry and Drug Control Faculty of Pharmacy in Hradec Králové, Charles University in Prague I prepared the mixture of six possible products (AAAA, AAAB, ABAB, AABB, ABBB, BBBB) using a statistical condensation starting from two different precursors - 5,6- bis(diethyamino)pyrazine-2,3-dicarbonitrile (A) and 5-diethylamino-6-[2-(4,4'- dimethoxytrifenymethoxy)-ethylamino]pyrazine-2,3-dicarbonitrile (B). Only compound of AAAB type was isolated by column chromatography from the mixture, purified and was characterized by NMR, IR, MS, UV-VIS spectroscopy. The precursor (B) was changed - 5-diethylamino-6-[2-(4,4'-dimethoxytrifenymethoxy)- ethylmethylamino]pyrazine-2,3-dicarbonitrile - and the statistical condensation was done the same way. Unfortunately the desired AAAB product was unstable and therefore the work was finished. In another part of this work I have studied a formation of proton-transfer complex with two molecules of pyridine. Three different AzaPc with hydroxy groups on periphery were used in this study. The influence of hydroxy groups on the rate constant was not confirmed. Then I used only one AzaPc -...
|
|
The arbitration: Comparison of legal regulation in the USA and the Czech Republic
Klobušníková, Ivana ; Kotoučová, Jiřina (advisor) ; Švarc, Zbyněk (referee)
The thesis deals with the area of questions regarding the law and practice of arbitration in the USA and the Czech Republic. The author aims to reflect the most significant differences between both legal systems that lead to the fundamentally different approaches to the arbitration in both countries. The paper is divided in seven chapters. The first two chapters describe the principles and law of arbitration both in the USA and Czech Republic. Third chapter deals with the problem of arbitrability of the dispute. The arbitration agreements and their essentials are considered in the fourth chapter. The fifth chapter has been dedicated to the arbitration proceedings and its particular stages with the aim to provide the reader with the complex overview of the course of the dispute. In the sixth chapter, the author analyzes revision, vacation and enforcement of the arbitral awards, whereas chapter seven is dedicated to the special issues such as interim measures, the application of the res iudicata principle, waiver of right to arbitrate and arbitrability of disputes arising of employment and consumer contracts.
|
|
Pokusy o rozlišení podjednotek trimerních a hexamerních forem purinnukleosidfosforylázy pomocí krystalové struktury komplexů purinových bází nukleosidů, acyklonukleosidů a jejich fosfonátových analogů
Bzowska, A. ; Stepniak, K. ; Olasek, M. ; Dlugosz, M. ; Wielgus-Kutrowska, B. ; Antosiewicz, J. ; Holý, Antonín ; Koellner, G. ; Stroh, A. ; Raszewski, G. ; Steiner, T. ; Frank, J.
Attempts to demonstrate and interpret differences between subunits forming biologically active oligomers of low-(calf spleen) and high-molecular mass (E. coli) purine nucleoside phosphorylases (PNP) yielded new crystal structures of both enzymes complexed with ground-state analogue ligands in space groups and with two full trimers and one full hexamer in the asymmetric unit, respectively.
|
|
Acceleration Methods for Evolutionary Design of Digital Circuits
Vašíček, Zdeněk ; Miller, Julian (referee) ; Zelinka,, Ivan (referee) ; Sekanina, Lukáš (advisor)
Ačkoliv můžeme v literatuře nalézt řadu příkladů prezentujících evoluční návrh jakožto zajímavou a slibnou alternativu k tradičním návrhovým technikám používaným v oblasti číslicových obvodů, praktické nasazení je často problematické zejména v důsledku tzv. problému škálovatelnosti, který se projevuje např. tak, že evoluční algoritmus je schopen poskytovat uspokojivé výsledky pouze pro malé instance řešeného problému. Vážný problém představuje tzv. problém škálovatelnosti evaluace fitness funkce, který je markantní zejména v oblasti syntézy kombinačních obvodů, kde doba potřebná pro ohodnocení kandidátního řešení typicky roste exponenciálně se zvyšujícím se počtem primárních vstupů. Tato disertační práce se zabývá návrhem několika metod umožňujících redukovat problem škálovatelnosti evaluace v oblasti evolučního návrhu a optimalizace číslicových systémů. Cílem je pomocí několika případových studií ukázat, že s využitím vhodných akceleračních technik jsou evoluční techniky schopny automaticky navrhovat inovativní/kompetitivní řešení praktických problémů. Aby bylo možné redukovat problém škálovatelnosti v oblasti evolučního návrhu číslicových filtrů, byl navržen doménově specifický akcelerátor na bázi FPGA. Tato problematika reprezentuje případ, kdy je nutné ohodnotit velké množství trénovacích dat a současně provést mnoho generací. Pomocí navrženého akcelerátoru se podařilo objevit efektivní implementace různých nelineárních obrazových filtrů. S využitím evolučně navržených filtrů byl vytvořen robustní nelineární filtr implusního šumu, který je chráněn užitným vzorem. Navržený filtr vykazuje v porovnání s konvenčními řešeními vysokou kvalitu filtrace a nízkou implementační cenu. Spojením evolučního návrhu a technik známých z oblasti formální verifikace se podařilo vytvořit systém umožňující výrazně redukovat problém škálovatelnosti evoluční syntézy kombinačních obvodů na úrovni hradel. Navržená metoda dovoluje produkovat komplexní a přesto kvalitní řešení, která jsou schopna konkurovat komerčním nástrojům pro logickou syntézu. Navržený algoritmus byl experimentálně ověřen na sadě několika benchmarkových obvodů včetně tzv. obtížně syntetizovatelných obvodů, kde dosahoval v průměru o 25% lepších výsledků než dostupné akademické i komerční nástroje. Poslední doménou, kterou se práce zabývá, je akcelerace evolučního návrhu lineárních systémů. Na příkladu evolučního návrhu násobiček s vícenásobnými konstantními koeficienty bylo ukázáno, že čas potřebný k evaluaci kandidátního řešení lze výrazně redukovat (defacto na ohodocení jediného testovacího vektoru), je-li brán v potaz charakter řešeného problému (v tomto případě linearita).
|
|
Securitization- A critical assessment in the light of the financial crisis
Marinova, Milena ; Krupová, Lenka (advisor) ; Marek, Petr (referee) ; Doubravský, Jiří (referee)
My dissertation thesis provides a comprehensive analysis of the principles of securitization techniques, of their attendant shortcomings, their regulatory treatment and the recent proposals for reducing complexity in accounting standards with relevance for securitizations. The explosion of securitization and related innovative credit risk transfer products largely expanded the magnitude and diversity of issuers, investors and securities. With this expansion numerous market participants began to wrongly believe that risk was not only shared more widely, but also that it disappeared from the system altogether. The application, or to be more precise, the misapplication of securitization in the mortgage market had fatal consequences for the financial sector worldwide. Before securitization, sub-prime mortgage lenders retained the loans that they originated on their balance sheets and therefore cared about their credit quality. Securitization techniques and related innovative financial instruments enabled the export of sub-prime mortgage structural problems from the United States globe-wide via the financial intermediaries. More over, securitization techniques and related credit risk transfer products enabled single banks to reduce their individual risk while at the same time transferred new and greater risks to the financial system. Meanwhile a lot was written on the causes for the recent financial crisis. In most cases inadequate ratings provided by the credit rating agencies and different principal agent problems were addressed. I present both for completeness in my work. However, I argue that not only the credit rating agencies are to blame for the inadequate reflection of securitization and related financial innovations and subsequently for the financial turmoil. The international and national financial supervisors in fact supported the credit rating agencies to further establish their businesses. What turned obvious during and after the financial turmoil started mid-2007 is that financial regulation failed to reach its main goal - ensuring stability of the financial system. It failed despite of the "regulatory achievements within Basel II" elaborated over the past ten years. In particular, securitization and related credit risk transfer products were not adequately treated in Basel II. Securitization-related products such as Credit Derivatives on Securitization Underlyings and numerous other complex financial innovations, as presented in my thesis, were not even thought of in Basel II. In fact, Basel II turned to do little to make the financial system more resilient. The need for further revisions in banking regulation is currently more than obvious. Furthermore, it is time to ask if the developments in Basel II are the right way to address the current risks within the financial system and hence if Basel II is the right way of banking regulation and supervision altogether. With the development of both Basel Accords (Basel I and Basel II) capital ratios became the center of banking regulation. However, capital ratios are obviously not sufficient as a measure for a systemic financial stability. These questions arise at least when financial stability and soundness are still the intended objectives and believed to be ensured through Basel II. My merits in this dissertation work root in the multi-facet analysis of securitization techniques that I provide. Up to date a comparable analysis of securitization techniques which addresses the wide spectrum of securitizations' issues - such as (i) their treatment and the related attendant flaws within the regulatory framework Basel II, (ii) the various microeconomic deficiencies related to securitizations, and (iii) the implicit macroeconomic threads of exporting credit risk and de-balancing financial stability through securitization techniques - has not been provided in the comprehensive way I built up my analysis. As a basis for my analysis, I provide a new classification of the characteristics of securitization techniques which were pre-crisis wrongly perceived as benefits. I analyze the reasons for the turmoil in the financial markets in their interplay and complexity and consider securitization techniques as a key driver for the financial crisis. I comprehensively criticize the current regulatory treatment. I present in detail why the recent financial crisis should be considered a clear regulatory failure due to the up to date short-sightedness of financial regulation. Through providing partial solutions and professional author's assessment of selected regulatory and accounting changes to securitizations I deliver an expert's contribution to the topic. My conclusions are that securitization markets, as they have been operating until today, brought a negative net macroeconomic effect which has been largely damaging to the global economy. I argue that international and national financial supervisors established an inadequate framework for financial regulation and supervision, and among other failures, even supported credit rating agencies to further establish their businesses. Further on, I show that early warning indicators of systemic risk in the financial sector and signs of the coming turmoil were irresponsibly ignored at the time they were perceived. What turned obvious during and after the recent financial turmoil is that capital regulation failed to reach its main goal -- ensuring stability of the financial system. In particular, securitization and related credit risk transfer products were adequately treated neither in Basel I nor in Basel II. Finally, I conclude that capital ratios as established with the development of both Basel Accords are not sufficient as a central measure for banking regulation and ensuring systemic financial stability.
|
guest ::
