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Study of mechanical properties and dynamics of biomembranes and single molecules with the use of laser beam - an overview
Jonáš, Alexandr ; Zemánek, Pavel
A micron-sized dielectric particle confined in a laser trap can be employed as a probe for the measurement of forces in the range from piconewtons to hundreds of piconewtons. Thus, if a biological system of interest (e.g. DNA molecule, single myosin or kinesin molecule, cell membrane) is attached to such a probe, its mechanical and dynamical properties (elasticity, viscosty, forces associated with movement) can be studied during its interaction with the environment with unprecedented resolution. This article introduces the basic principles of the laser trapping and force measurement and illustrates on several examples the great potential of the light-based force transducer for exploiting non-invasively the dynamics of basic biological systems.
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External Sources of Finance for Business Projects in the Czech Republic
Kubíčková, Kateřina ; Filipová, Vladimíra (advisor) ; Drozen, František (referee)
This bachelor thesis is focused on external sources of finance for business projects in the Czech Republic. The theoretical framework summarizes the expertise and definitions relating to business, entrepreneurs personality, to legal forms of business and traditional external sources of finance. As the lack of resources or difficult access to traditional sources of capital can sometimes be an obstacle in the realization of a welcome and viable business plan, the second half of the thesis is devoted to alternative options of financing business projects with an emphasis on EU subsidies drawing. Other analysed external sources of finance are the investments of private investors called Business Angels, venture and private equity capital, crowdfunding and at the end preferential credits from banking institutions offered to start-ups or new business projects. The main target of this thesis is to provide an overview of the available external projects funding, to find out how they are going on in the Czech Republic and at the conclusion to assess, what kinds of projects are suitable for every single kind of funding. This thesis could help to entrepreneurs, who do not have enough funds for their idea, to be knowledgeable in current options of external financial sources.
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The impact of the economic cycle to finance the defense of the Czech republic in years 2004-2014
Heres, Ondřej ; Chmelová, Pavla (advisor) ; Strejček, Ivo (referee)
This bachelor work examines the impact of economic performance on financing the defense sector in the Czech Republic in the years 2004-2014. The main questions are whether this influence is clear and the extent to which is essential for funding this sector. The work also provides a basic overview about development and structure of the Ministry of Defence budget in these years. The theoretical part contains theories of business cycle and public sector and briefly introduces the basic institutions that are tasked to provide a defense. The analytic part analyzes the expenditures and revenues of the Ministry of Defence and assesses their mutual influence and simultaneously the influence of GDP on these indicators. To compare with previous findings, the GPD growth rate and the growth rate of defense expenditures in selected countries of NATO are analyzed in brief in the last chapter. While findings based on data from the Ministry of Defence have rather anticyclical development of defense expenditures, in selected countries of NATO, the development is more procyclical. It highlights the very ambiguous impact of the economic cycle on expenditures in the defense sector.
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Valuation of company Lesní společnost Broumov Holding, a. s.
Sichrovský, Chananel ; Štamfestová, Petra (advisor) ; Toušek, Jan (referee)
The aim of this master thesis is to estimate the value of the company Lesní společnost Broumov Holding, a. s. as of the valuation date 01/01/2016. The thesis consists of two main parts, theoretically-methodological and related practical part. For accomplishing the objective, the strategical and financial analysis were made, also the main generators of the value were identified and scheduled and the financial plan was composed. The valuation itself was realized by three different methods that were afterwards calculated together which resulted into final estimation of the company's value, that reaches 147 024 thousand Czech crowns. The thesis is usable as a full overview of the company's situation and may be also helpful to the owners as a base for price negotiations, in case of potential investor's interest in buying it.
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Outsourcing and its impacts on company through Enterprise architecture
Štěpán, Jakub ; Šebesta, Michal (advisor) ; Bruckner, Tomáš (referee)
This final thesis is dealing with the theme of outsourcing and its influence on company in connection with enterprise architecture as the main carrier of ongoing changes. Main focus of this thesis is to provide the overview of the area of Enterprise architecture and outsourcing as well as the description of the selected notation of Enterprise architecture modeling, which will be main instrument in describing the transformation. Theoretical part of the work is divided into three parts. Firstly there is description of the enterprise architecture and chosen connected areas, followed by description of the outsourcing process and description of the modeling language ArchiMate. Practical part of the work is composed of analysis, description and evaluation of the transformation of the selected company. Among the main contribution of this thesis there is description of the changes during the transformation using the ArchiMate modeling language and identifying of concrete impacts of outsourcing on Enterprise architecture of the company.
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Možnosti využití sociálních sítí pro podporu podnikání v autoservisech
Mischaniuk, Mykhailo ; Molnár, Zdeněk (advisor) ; Gála, Libor (referee)
The diploma thesis deals with the problem of using social networks in the field of car repair services. The primary aim is to provide the recommendations for businesses in a structured way on how to better utilize these networks to get better competitiveness. This work is divided into three parts. The first theoretical part deals with basic description of networks and their statistics. This part also covers some basic tools that we can use to analyze and maintain social network platforms. The second analytical part deals with competitive analysis in car repair services and gives an overview of the most popular Runet social network platforms. The third practical part provides structured view on all important aspects of social platform maintenance and behaviour. In this section, you can find the description of various views and the recommendations I give to the specific car repair service.
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Comparison of accounting programs from the point of view of the use of information for management companies
Loušová, Petra ; Stejskalová, Irena (advisor) ; Pevná, Jana (referee)
The aim of the thesis is to compare accounting programs from the point of view of the use of information that are important for management companies. The theoretical part deals with the general approach to processing business information in the accounting. Next there is explained an overview of what information in the field of accounting are important and necessary for the job of financial manager. The practical part contains an analysis of at least three accounting programs, with the main focus on what information from the selected accounting program managers need in their work and what information is actually gaining from the program. In practical part, there are also compared results of individual organizations; information is gathered through in-depth interview with financial managers selected companies.
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Taxation of Employee benefits in the chosen EU countries
Nguyenová, Phuong ; Rytířová, Lucie (advisor) ; Finardi, Savina (referee)
This diploma thesis aims to compare taxation of employee benefits in particular EU countries and identify their impact on employees and also employers. The main goal is to summarize the procedures that need to be done when dealing with benefits as well as state several suggestions for prospective reader. The thesis is divided into four chapters. First chapter defines employee benefits. Second chapter analyses benefits from employee's and employer's point of view. Third chapter gives detailed overview of benefits' taxation in selected countries of European Union. These countries are the Czech Republic, Slovakia and Austria. Finally last chapter contains several practical examples which show how to proceed when determining the amount of tax, while simultaneously comparing the differences in taxation between countries.
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Clustering and regression analysis of micro panel data
Sobíšek, Lukáš ; Pecáková, Iva (advisor) ; Komárek, Arnošt (referee) ; Brabec, Marek (referee)
The main purpose of panel studies is to analyze changes in values of studied variables over time. In micro panel research, a large number of elements are periodically observed within the relatively short time period of just a few years. Moreover, the number of repeated measurements is small. This dissertation deals with contemporary approaches to the regression and the clustering analysis of micro panel data. One of the approaches to the micro panel analysis is to use multivariate statistical models originally designed for crosssectional data and modify them in order to take into account the within-subject correlation. The thesis summarizes available tools for the regression analysis of micro panel data. The known and currently used linear mixed effects models for a normally distributed dependent variable are recapitulated. Besides that, new approaches for analysis of a response variable with other than normal distribution are presented. These approaches include the generalized marginal linear model, the generalized linear mixed effects model and the Bayesian modelling approach. In addition to describing the aforementioned models, the paper also includes a brief overview of their implementation in the R software. The difficulty with the regression models adjusted for micro panel data is the ambiguity of their parameters estimation. This thesis proposes a way to improve the estimations through the cluster analysis. For this reason, the thesis also contains a description of methods of the cluster analysis of micro panel data. Because supply of the methods is limited, the main goal of this paper is to devise its own two-step approach for clustering micro panel data. In the first step, the panel data are transformed into a static form using a set of proposed characteristics of dynamics. These characteristics represent different features of time course of the observed variables. In the second step, the elements are clustered by conventional spatial clustering techniques (agglomerative clustering and the C-means partitioning). The clustering is based on a dissimilarity matrix of the values of clustering variables calculated in the first step. Another goal of this paper is to find out whether the suggested procedure leads to an improvement in quality of the regression models for this type of data. By means of a simulation study, the procedure drafted herein is compared to the procedure applied in the kml package of the R software, as well as to the clustering characteristics proposed by Urso (2004). The simulation study demonstrated better results of the proposed combination of clustering variables as compared to the other combinations currently used. A corresponding script written in the R-language represents another benefit of this paper. It is available on the attached CD and it can be used for analyses of readers own micro panel data.
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Usage of unstructured data in Business Intelligence
Rakhmanova, Malika ; Šperková, Lucie (advisor) ; Karkošková, Soňa (referee)
The aim of the thesis is to identify the main trends that are occurring in the market of Business Intelligence and related to unstructured data, to describe the possibilities for integrating unstructured data, to clarify what the impact on the company have the results that can be obtained using these solutions and how generally incorporate an analysis of unstructured data into BI. Another aim is to show the current situation of processing unstructured data on the example of BI system. The thesis is divided into several parts. First part is describing of the Business Intelligence area and the basic components of Business Intelligence, as well as identifying market trends. Then, there is the next part: separating the data into structured and unstructured. Here is the part about how you can access and analyse unstructured data and what is their place in BI systems. This is the end of a block of unstructured data and the beginning of a description of the enhanced version of BI. Finally, the current market situation and BI tools, which include unstructured data, are introduced. This section provides an overview of how BI tools approach to analyse unstructured data. Existed literature, professional and freely available Internet resources are used for writing the work. The purpose is to serve as a source of information for quickly orienting in the current situation, to serve as a guide to the world of BI solutions and to show potential users what are the options and functionality of these BI solutions.
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