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Needs of patients with age related macular degeneration
Houdková, Eliška ; Jirkovský, Daniel (advisor) ; Haluzíková, Jana (referee)
This bachelor's thesis deals with the area of specific needs in patients with age-related macular degeneration (AMD). Objectives: The aim of this thesis is to provide an overview of the changed needs of patients with AMD. Methods: To achieve the aim of the thesis, a questionnaire survey was conducted. The target group of the survey were patients undergoing anti-VEGF therapy at an unnamed eye clinic. A total of 70 questionnaires were included in the survey. Results: Based on the statistical evaluation of the data, it was found that AMD significantly affects the lives of respondents in many areas. The majority of respondents identified independence and self-sufficiency as the most affected aspect of their lives. More than half of the respondents (55.71 %) have problems with mobility and everyday activities. AMD also negatively affects the mental health of patients, 70 % of respondents are afraid of depression or anxiety. Respondents find meaning and fulfillment in life, especially in the areas of family and friends relationships, leisure activities, spiritual development, education, gratitude, and a positive attitude towards life. Conclusion: AMD has a complex impact on the lives of patients. It is important to provide patients with AMD with high-quality and accessible care that includes not only...
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HPLC in quality control of food supplements based on goldenrod and containing rutin and chlorogenic acid
Kotyková, Klára ; Šatínský, Dalibor (advisor) ; Chocholoušová Havlíková, Lucie (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Analytical Chemistry Candidate: Klára Kotyková Supervisor: prof. RNDr. Dalibor Šatínský, Ph.D. Title of the diploma thesis: HPLC in quality control of food supplements based on goldenrod and containing rutin and chlorogenic acid In this diploma thesis, a high-performance liquid chromatography (HPLC) method was developed and validated for the separation and determination of chlorogenic acid, 3,5- dicaffeoylquinic acid, rutin, quercetin, and kaempferol. This method was applied to the analysis of food supplements based on goldenrod: drops Celík zlatobýl (Valdemar Grešík), Celík obecný BIO (Bylinné kapky), Celík obecný (Bylinné kapky), Zlatobýl (Green Idea), Zlatobýl - tinktura z pupenů (Serafin), Zlatobýl - tinktura z bylin (Serafin), Zlatobýlová směs (Dědek kořenář), Zlatobýl (Inca Botanica), and capsules Celík (Ex Herbis). Furthermore, two food supplements containing rutin (Solgar and Walmark®) and a food supplement Zelená káva (Botanic) containing chlorogenic acid were analyzed. An Ascentis® Express 90 Å AQ-C18 150 × 4.6 mm column with 2.7 µm particles was selected for analysis. A gradient elution with a mobile phase of acetonitrile/0.085% phosphoric acid was used. Detection was performed with a diode array detector at...
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Functional movement disorders of the temporomandibular joint in women of working age
Nulíčková, Denisa ; Benešová, Lucie (advisor) ; Málková, Magdaléna (referee)
BACHELOR THESIS ABSTRACT Author: Denisa Nulíčková Supervisor: Mgr. Lucie Benešová Title: Functional movement disorders of the temporomandibular joint in women of working age Abstract: The bachelor thesis deals with functional disorders of the temporomandibular joint in women of working age. The thesis is a diagnostic work. The main aim is to evaluate the most common functional changes and general common features of patients with temporomandibular joint dysfunction by means of extended kinesiological analysis. The sub-objective is to map the quality of life and the presence of stress factors in the patients' lives. The second sub-objective is to elaborate the proposal and goals of the physiotherapy intervention. The theoretical part, in addition to short chapters describing the anatomy and biomechanics of the temporomandibular joint, deals with functional temporomandibular disorders. It provides a comprehensive overview of their causes, symptomatology and relationship to other body structures. It also summarizes the consequences of excessive psychological stress in the context of these disorders and describes conservative methods of treatment. The practical part of the thesis consists of 5 case studies, which include detailed initial examinations. The standard kinesiological analysis is enriched with...
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Impact of leisure and social activites on quality of life among erderly in Europe - SHARE data analysis
Pluhařová, Markéta
Impact of leisure and social activites on quality of life among erderly in Europe - SHARE data analysis Abstract Due to demographic aging, the quality of life of an increasing proportion of seniors is becoming more important than ever. According to activity theory and the concept of active aging, active life is a way to experience good old age. The diploma thesis focuses on the impacts of leisure and social activities on the quality of life of elderly over 65 in 17 European countries. Sixth wave data from The Survey of Health, Aging and Retirement in Europe (SHARE) from 2015 and the easySHARE panel dataset are analyzed using binary regression analysis and multilevel modeling using binary regression analysis. The relationship of 11 selected activities, which were divided for the needs of this thesis into social, individual activities and activities aimed at helping others, and quality of life is controlled for socio-economic, demographic and health characteristics. Quality of life is meassured using the CASP-12 indicator. For social and individual activities, active elderly have a higher chance of a high quality of life (CASP-12 score> 39) than inactive. Elderly who do not provide personal care assistance to people from the same household also have a better chance than caregivers. Key words ageing, ageing of...
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Fire as an alternative way of the landscape management
Maximov, Fedor ; Novák, Jan (advisor) ; Adámek, Martin (referee)
Prescribed burning is a method that has been used since prehistoric times to keep unforested areas. In pastures, fire was used to remove dead biomass, return nutrients to the soil and improve forage quality, as well as to convert forests fields to a shifting agriculture. The abandonment of burning in the last century has led to an accumulation of plant biomass in the landscape. This, combined with global warming, is now creating the threat of dangerous fires. In 2022, controlled burning was allowed in the Czech Republic as a way of managing habitats that are at risk of becoming woodland without proper management. Rare heliophilous plant and animal species are tied to them. It would therefore be advisable to reintroduce this management method, together with monitoring and control of its effects on species and communities. The aim of this backelor thesis is to summarise the existing knowledge about prescribed burning in Europe. It also describes how controlled burning affects the dynamics of dry grasslands and heathlands. The main focus is on attributes of controlled burning that can be used to maintain selected habitats. Keywords: fire, vegetation, landscape management, succession
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Planetary boundary layer height estimation
Růžičková, Barbora ; Zíková, Naděžda (advisor) ; Holubová Šmejkalová, Adéla (referee)
The planetary boundary layer height (PBLH) is a key parameter for investigating interactions between the Earth's surface and the atmosphere, especially for air quality assessment and pollutants' dispersion. The PBLH is highly variable in time and space as is influenced by a number of factors originating both in the atmosphere and at the Earth's surface. In this bachelor thesis, the PBLH and mixing layer height (MLH) measured at the National Atmospheric Observatory Košetice over the three-year period 2020-2022 using the Vaisala CL61 ceilometer were evaluated. For both observed variables, a significant difference was found between the values measured in summer and winter: 1710 ± 760 m and 1010 ± 650 m for PBLH, 920 ± 700 m and 420 ± 330 m for MLH. Significant diurnal variability was also observed, with maxima at 15:00 UTC and minima at 03:00 UTC for PBLH and maxima at 14:00 UTC and minima at 22:00 UTC for MLH. The relationship between planetary boundary layer height and the occurrence of cyclonic and anticyclonic synoptic situations was also investigated, but was not conclusive due to the complexity of the weather patterns of each synoptic situation. Keywords: atmospheric boundary layer, mixing layer, ceilometer, ground-based remote sensing, atmospheric vertical profile
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In vitro fertilization in horses
Müller, Filip ; Šušor, Andrej (advisor) ; Šimoník, Ondřej (referee)
Reproductive management in horse breeding increasingly relies on in vitro fertilization (IVF) techniques. This technology entails a complex process, including the acquisition of immature oocytes, their in vitro maturation, fertilization with sperm, and subsequent cultivation of the early embryo before transfer into a synchronized recipient. However, the success of equine IVF is influenced by various factors such as oocyte quality, sperm capacitation, and technical issues unique to this process, compared to other mammalian models. This bachelor's thesis aims to summarize and evaluate current knowledge on IVF of horse eggs, identify key factors influencing success, and describe current procedures for gamete preparation. By incorporating the latest IVF approaches and optimizing them, a higher success rate can be achieved. Key aspects for improving equine IVF include gamete collection and handling, in vitro oocyte maturation, sperm capacitation, and subsequent embryonic development.
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Effect of acute sleep deprivation in different light conditions on the quality of recovery sleep
Zeithamlová, Barbora ; Kopřivová, Jana (advisor) ; Vlček, Kamil (referee)
Sleep is regulated by homeostatic and circadian processes. The circadian process is controlled by the internal biological clock, which is regularly synchronised with the external world by so-called zeitgebers. The most important zeitgeber for humans is light, therefore incorrect timing of light signals can lead to desynchronisation of the clock and sleep disruption; however, this depends on the intensity and spectral characteristics of the light. Dimmed red light is unlikely to significantly interfere with sleep regulation, but white light with a higher intensity could. White light is typically used when people stay awake during the night and experience acute total sleep deprivation. This could potentially interfere with the compensatory mechanisms occurring during subsequent recovery sleep. We therefore decided to test whether and how different lighting conditions during sleep deprivation can affect the structure of recovery sleep. We had 12 healthy uniform volunteers undergo two acute total sleep deprivations; one under normal white light, the other under dim red light. Using polysomnography, we measured the sleep parameters of both recovery sleeps and compared them. It turned out that sleep that occurred after the sleep deprivation in constant dim light conditions was less fragmented, had...
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The effect of sleep on muscle hypertrophy
Toušková, Barbora ; Skálová, Kateřina (advisor) ; Kolář, David (referee)
Sleep represents one of the fundamental aspects of human life and health, influencing many physiological functions including muscle hypertrophy. Sleep is regulated by various external and internal stimuli, such as the circadian rhythm, body temperature, gene expression, and the synthesis of hormones and neurotransmitters such as melatonin and adenosine. Muscle hypertrophy is a complex process of enlarging muscle fibers, which is associated with numerous metabolic processes and signaling pathways, including the IGF-1-PI3K-Akt- mTOR axis, and is regulated by hormones such as testosterone, GH, myostatin, and activin. Most of these hypertrophic factors are closely linked to quality and sufficient duration of sleep. Sleep deprivation negatively affects almost all processes involved in muscle hypertrophy and, in the long term, leads to muscle loss instead. Key words: Sleep, circadian rhythm, melatonin, muscle hypertrophy, Akt, mTOR, sleep deprivation
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Development of an HPLC method for quality control of food supplements based on valerian extract
Bílková, Veronika ; Šatínský, Dalibor (advisor) ; Sklenářová, Hana (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Analytical Chemistry Candidate: Veronika Bílková Supervisor: prof. RNDr. Dalibor Šatínský, Ph.D. Title of the diploma thesis: Development of a HPLC method for quality control of food supplements based on valerian extract In this diploma thesis, a new chromatography method for separation and determination of apigenin-7-glucoside, luteolin, acetoxyvalerenic acid, hydroxyvalerenic acid, valerenic acid, acevaltrate, and valepotriate in valerian extract was developed and validated. The chromatography method was subsequently used to determine the content of the active substances in food supplements: Advance Calmin, Allnature Kozlík bylinný extrakt, Anxiolan from Green-Swan Pharmaceuticals CR a.s., Barnys HypnoX forte from Biopol GN, Dr. Max Happy Sleep, Epiderma Spi v klidu, Kneipp Kozlík plus, NatureVia Sleepnox forte, Naturvita Antistres, Neospan forte od Simply You Pharmaceuticals a.s. and Terezia Spánek & Relax. To compare the content of substances, registered medicinal products were analyzed: Kneipp Kozlík 500 mg, Persen forte - Zentiva Group, a.s.. The method was also applied for quality control of liquid medicinal forms (drops, tinctures): Dr. Popov Kozlík lékařský, Green idea Kozlík lékařský extrakt and Tinctura valerianae...
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