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Memory Subsystem Simulator
Holášek, Petr ; Janoušek, Vladimír (referee) ; Peringer, Petr (advisor)
This theses describes aspects of memory traces processing, its applications in simulation and development of modular memory subsystem simulator based on memory traces. The simulator also supports use for educational purposes thanks to built-in visualization which can be used to track address accesses in memory subsystem hierarchy.
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Phototropic memory in early plant development
Šišková, Michaela ; Konrádová, Hana (advisor) ; Krtková, Jana (referee)
This thesis was inspired by controversial published results on the existence and reliability of a memory trace of the direction of the last illumination in young dicots. The theoretical part first covers phototropism, it briefly summarizes current knowledge about this growth movement, phototropins, and the mechanism of phototropic bending, including the role of auxin and its transporters. It also discusses the effect of previous light exposure on hypocotyl bending. Another section of the theoretical part is focused on the question of the existence of memory in plants. The experiments performed in the practical part are based on the assumption that plants are able to store a memory trace of previous light exposure. After the establishment of a system that made it possible to obtain a robust phototropic response to blue light, seedlings of the model plant Lepidium sativum were tested under different conditions to see if and how the direction of light affected the plants' response to subsequent phototropic stimulation. The results suggest that in at least one case, the final phototropic response could be interpreted as a formation of a specific memory trace in the tested plants. However, based on the results of this work, the existence of a memory trace of previous light exposure cannot be...
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Delineating pain and fear engrams in the prefrontal cortex
Ludínová, Kristýna ; Zitko, Jan (advisor) ; Herink, Josef (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Chemistry and Pharmaceutical Analysis Candidate: Kristýna Ludínova Supervisor: PharmDr. Jan Zitko, Ph.D. External supervisors: Dr. Manfred Oswald, Prof. Dr. Rohini Kuner Title of diploma thesis: Delineating Pain and Fear Engrams in the Prefrontal Cortex Pain is a complex process associated with activation of various brain centres. According to evidence of imaging studies in humans and rodents the medial prefrontal cortex (mPFC) ranks amongst the brain area consistently activated during painful perception. The mPFC circuits underlies functionally-distinct processes, such as pain, emotional response, decision-making, attention amongst others. However, the precise contribution of mPFC in pain related function remains to be unknown. The aim of the study was to delineate how pain and fear are manifested at the cellular level within the regions of PFC. By employing activity dependent neuronal labelling we tested if cellular ensembles activated in pain and fear behaviours within the mPFC are distinct. We investigated a potential use of activity-dependent DREADDs (Designer Receptors Exclusively Activated by Designer Drugs) expression in order to test for the functional role of PFC ensembles in pain and fear behaviour. Our...
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Delineating pain and fear engrams in the prefrontal cortex
Ludínová, Kristýna ; Zitko, Jan (advisor) ; Herink, Josef (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Chemistry and Pharmaceutical Analysis Candidate: Kristýna Ludínova Supervisor: PharmDr. Jan Zitko, Ph.D. External supervisors: Dr. Manfred Oswald, Prof. Dr. Rohini Kuner Title of diploma thesis: Delineating Pain and Fear Engrams in the Prefrontal Cortex Pain is a complex process associated with activation of various brain centres. According to evidence of imaging studies in humans and rodents the medial prefrontal cortex (mPFC) ranks amongst the brain area consistently activated during painful perception. The mPFC circuits underlies functionally-distinct processes, such as pain, emotional response, decision-making, attention amongst others. However, the precise contribution of mPFC in pain related function remains to be unknown. The aim of the study was to delineate how pain and fear are manifested at the cellular level within the regions of PFC. By employing activity dependent neuronal labelling we tested if cellular ensembles activated in pain and fear behaviours within the mPFC are distinct. We investigated a potential use of activity-dependent DREADDs (Designer Receptors Exclusively Activated by Designer Drugs) expression in order to test for the functional role of PFC ensembles in pain and fear behaviour. Our...
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Delineating pain and fear engrams in the prefrontal cortex
Ludínová, Kristýna ; Zitko, Jan (advisor) ; Herink, Josef (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Chemistry and Pharmaceutical Analysis Candidate: Kristýna Ludínova Supervisor: PharmDr. Jan Zitko, Ph.D. External supervisors: Dr. Manfred Oswald, Prof. Dr. Rohini Kuner Title of diploma thesis: Delineating Pain and Fear Engrams in the Prefrontal Cortex Pain is a complex process associated with activation of various brain centres. According to evidence of imaging studies in humans and rodents the medial prefrontal cortex (mPFC) ranks amongst the brain area consistently activated during painful perception. The mPFC circuits underlies functionally-distinct processes, such as pain, emotional response, decision-making, attention amongst others. However, the precise contribution of mPFC in pain related function remains to be unknown. The aim of the study was to delineate how pain and fear are manifested at the cellular level within the regions of PFC. By employing activity dependent neuronal labelling we tested if cellular ensembles activated in pain and fear behaviours within the mPFC are distinct. We investigated a potential use of activity-dependent DREADDs (Designer Receptors Exclusively Activated by Designer Drugs) expression in order to test for the functional role of PFC ensembles in pain and fear behaviour. Our...
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Memory Subsystem Simulator
Holášek, Petr ; Janoušek, Vladimír (referee) ; Peringer, Petr (advisor)
This theses describes aspects of memory traces processing, its applications in simulation and development of modular memory subsystem simulator based on memory traces. The simulator also supports use for educational purposes thanks to built-in visualization which can be used to track address accesses in memory subsystem hierarchy.
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