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HTTP Implementation with a Local Cache
Šváb, Michal ; Burgetová, Ivana (referee) ; Burget, Radek (advisor)
This thesis describes problems of HTTP 1.1 protocol implementation with local cache. It describes creation of application programming interface for sending requests and receiving responses. Each response, that meets certain criteria is stored locally and then used for another requests for same document. The protocol is implemented in Java programming language, supporting version 5 and higher.
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Prediction of therapeutical response to neoadjuvant therapy in rectal cancer
Pazdírek, Filip ; Hoch, Jiří (advisor) ; Martínek, Lubomír (referee) ; Šimša, Jaromír (referee)
The treatment of locally advanced rectal cancer is multimodal. It includes neoadjuvant radiochemotherapy (NCHRT), which reduces the risk of local recurrence. However, this treatment is also accompanied by side effects. Accordingly, there is an unmet need to identify predictive markers allowing to identify non-responders to avoid its adverse effects. We monitored circulating tumor DNA (ctDNA) as a potential liquid biopsy-based biomarker. We have investigated ctDNA changes plasma during the early days of NCHRT and its relationship to the immediate tumor response as well as overall patients survival. In all patients, ctDNA was strongly reduced or completely eliminated from plasma by the end of the first week of NCHRT, with no correlation to any of the parameters analyzed. As ctDNA was reduced indiscriminately from the circulation of all patients, therefore the dynamics during the first week of NCHRT is not suitable for predicting the immediate therapeutic response in rectal cancer. The baseline ctDNA presence represented a statistically significant negative prognostic biomarker for the overall patient survival. However, the general effect of rapid ctDNA disappearance apparently occurring during the initial days of NCHRT is noteworthy and should further be studied. Keywords: rectal cancer, neoadjuvant...
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Dose-response curves
Hezoučký, Martin ; Hlávka, Zdeněk (advisor) ; Maciak, Matúš (referee)
Title: Dose-response curves Author: Martin Hezoučký Department: Department of Probability and Mathematical Statistics Supervisor: doc. RNDr. Zdeněk Hlávka, Ph.D., Department of Probability and Mathematical Statistics Abstract: In this thesis, we deal with the process of research and development of new medical substances with a focus on statistical methods used to determine appropriate doses. For this purpose, we examine the dose-response relationship. First, we describe a typical procedure for the development of a new drug. Second, we focus in detail on the MCP-Mod method. Third, we propose a new method based on the theory of gradual change models. This approach tests whether the administration of the drug has a significant effect. If so, the dose with desired effect is estimated using an appropriate model. Specifically, we provide an esti- mate using linear, quadratic and Emax gradual change models. We also describe a construction of a confidence interval for the point of change and also for the dose with the desired effect. The advantage of the proposed method over the MCP-Mod is the determination of the confidence intervals. Finally, we apply the above mentioned methods to data from the U.S. Tox21 research program and compare the results based on several tested substances and clearly demonstrate the...
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Dose-response curves
Hezoučký, Martin ; Hlávka, Zdeněk (advisor) ; Maciak, Matúš (referee)
Title: Dose-response curves Author: Martin Hezoučký Department: Department of Probability and Mathematical Statistics Supervisor: doc. RNDr. Zdeněk Hlávka, Ph.D., Department of Probability and Mathematical Statistics Abstract: In this thesis, we deal with the process of research and development of new medical substances with a focus on statistical methods used to determine appropriate doses. For this purpose, we examine the dose-response relationship. First, we describe a typical procedure for the development of a new drug. Second, we focus in detail on the MCP-Mod method. Third, we propose a new method based on the theory of gradual change models. This approach tests whether the administration of the drug has a significant effect. If so, the dose with desired effect is estimated using an appropriate model. Specifically, we provide an esti- mate using linear, quadratic and Emax gradual change models. We also describe a construction of a confidence interval for the point of change and also for the dose with the desired effect. The advantage of the proposed method over the MCP-Mod is the determination of the confidence intervals. Finally, we apply the above mentioned methods to data from the U.S. Tox21 research program and compare the results based on several tested substances and clearly demonstrate the...
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Sports Interview and Its Specifics - with Focus on Czech Audio-Visual Media Practice
Lichnovský, Tomáš ; Záruba, Robert (advisor) ; Macková, Veronika (referee)
The interview is one of the journalist's basic methods and that statement also applies to the field of sport journalism. Through talking with athletes, the journalist gets information he afterwards shares with readers, listeners or viewers. When author decides to publish acquired material in the original dialogical form, it becomes of the interview genre. How would an ideal sport interview look like in this respect? What skills should a good sports journalist have? And how to ask the athlete not to answer "obviously"? The explanation on this topic has not existed in the Czech aca- demic sphere yet. For the first time, the diploma thesis Sport interview and Its Spe- cifics has tried to find the supported answers to the previous questions. In four explanatory chapters, the reader is introduced to the issue of media dia- logues with persons from the sports environment. The emphasis is laid on Czech audiovisual media area where the sport interview takes many forms. Besides a lit- erature research and the author's sports journalist practice, the thesis is based on interviews with leading Czech sports journalists. Their comments and tips are an essential part of the written theory. And what do the respondents think about sports journalists and the communication with them? A few notes of four Czech fa-...
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Communicative strategies of politicians in interaction.
Lokajová, Jana ; Šaldová, Pavlína (advisor) ; Klégr, Aleš (referee)
Abstract. The aim of this M.A. thesis is to apply on the sample of five transcribed interviews with American politicians the typology of strategies devised by social psychologists P. Bull and K. Mayer (1993) for 'non-replies' of British politicians in the genre of a political interview and to determine whether this typology could be qualitatively correlated to specific linguistic means (the use of passive, pronominal shifts, hedges). The responses of politicians are examined within the CDA method also in relation to the macro-principles of evasion (dissimulation), coercion, legitimation and delegitimation, which are claimed to be valid in political discourse by P. Chilton (2004) in order to discover whether Bull and Mayer's social typology could be related to these principles and to the strategies of face-management (Brown and Levinson 1987). It is expected that politicians will boost their positive image in the interview and coerce the public in the agenda shift (Clayman, Heritage 2002) through every response in the interview. A question which according to Bull and Elliott (1996) consists of face threat is also expected to be attacked; quantitative results are presented which verify this assumption. In addition, as thirty strategies were observed to have been employed by Mrs Thatcher and Neil Kinnock in...
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Right to Answer in Selected Countries: Study 5.248
Medková, Eva ; Syllová, Jindřiška ; Bartůšek, Pavel
Po stručném historickém exkurzu vývoje práva na odpověď se studie věnuje obecným teoretickým otázkám. Zmiňuje se o jednotlivých koncepcích tohoto práva, které se v jednotlivých právních úpravách vyskytují a vyjadřuje se i k jeho vztahu k ochraně, kterou nabízí občanské právo. Pojednává i o úpravě, která byla doporučena pro členské státy Rady Evropy. Těžiště studie však spočívá v popisu jednotlivých právních úprav institutu práva na odpověď ve vybraných evropských státech. Struktura textu popisu jednotlivých úprav sleduje toto schéma: po vymezení pramenů práva je pozornost věnována obsahu samotného institutu a tomu, kdo je oprávněnou osobou. Dále je vymezen způsob, jakým se reaguje na žádost oprávněné osoby domáhající se svého práva, tzn. uveřejnění či odmítnutí odpovědi, a též je pojednáno o možnosti právní ochrany oprávněné osoby pro případ, že dojde k porušení práva. V některých případech jsou také stručně uvedeny instituty s právem na odpověď související
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HTTP Implementation with a Local Cache
Šváb, Michal ; Burgetová, Ivana (referee) ; Burget, Radek (advisor)
This thesis describes problems of HTTP 1.1 protocol implementation with local cache. It describes creation of application programming interface for sending requests and receiving responses. Each response, that meets certain criteria is stored locally and then used for another requests for same document. The protocol is implemented in Java programming language, supporting version 5 and higher.
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