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Effect of gluten-free diet on potentially regulatory immune mechanisms in human type 1 diabetes
Císařová, Radka ; Funda, David (advisor) ; Zadražil, Zdeněk (referee)
Type 1 diabetes (T1D) is an autoimmune disease, whose incidence is rising every year, and its prevention or a cure does not exist. T1D is influenced by multiple genetic factors but environmental factors represent the major contributor to the recent almost epidemic increase of T1D incidence worldwide, primarily in developed countries. Amongst these factors belong for example enteroviral infections, microbiota dysbiosis or gluten-free diet (GFD). GFD has been proven to have a protective effect in NOD mice, which is a spontaneous model of T1D, and a beneficial effect on glycemic control in humans, when administered after T1D onset. This diploma thesis examined changes of regulatory and potentially regulatory T-cells and their cytokines in peripheral blood mononuclear cells (PBMC) of T1D children, who underwent 12-month intervention trial of GFD. Secondly, the thesis assessed if the influence of GFD on immune regulatory functions can be transferred by colonization of germ-free NOD mice with gut microbiota of these children. We have found that intervention with GFD increases percentage of Tr1 cells and IL-10 producing CD4+ T-cells in PBMC of T1D children. Furthermore, the beneficial effect on immune regulation can be at least partially transferred to NOD mice by the colonization with human microbiota...
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European Regions as an Example of the Relationship between Human, Institutional and Social Capital and Economic Performance
Chudý, Vít ; Netrdová, Pavlína (advisor) ; Pileček, Jan (referee)
This thesis is focused on the description and assessment of the relationships between human, institutional and social capital and the assessment of the effects of capital types on economic performance. After the operationalization of capital types and economic performance that was based on literature research, the relationships were analysed using the example of European regions (specifically NUTS 2). The analysis is focused on the regional differentiation of capital types and economic maturity. It also monitors the relationships between capital types and economic performance. This thesis is based on the latest statistical data from offices and surveys that deal with the quality of the institutional environment or the characteristics of social capital. The characteristics of capital types are shown in maps. For the statistical data analysis, we used factor, correlation and regressive analysis. Keywords: human, social and institutional capital, economic performance, GDP per capita, regional differentiation, European regions NUTS 2
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Evaluation of the components of intellectual capital on the example of selected company
Obolenskiy, Vladimir ; Němec, Otakar (advisor) ; Mácha, Tomáš (referee)
Evaluation of the components of intellectual capital of the cmpany with focus on human capital and the associated analysis and comparison of the education and development processes in the company. Description of the concept and function of intellectual capital. The distribution of intellectual capital components and the description of the structure oc IC. Theoretical analysis of the relationship of intellectual capital and intellectual property. Description of the current state assessment of intellectual property and intangible assets. Characteristics of methods for evaluation of intellectual capital. The discrepancy between the accounting and valuation standards. The analysis of the possible development of human component of intellectual capital. Implementation of the general human capital assessment firm using the method of allocation weights, interviewed employees and managers, and developing a plan to increase employees' qualification for next year.
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