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The influence of prenatal hormones on the emergence and development of homosexual orientation in women with congenital adrenal hyperplasia.
Pakhomova, Alena ; Havlíček, Jan (advisor) ; Šebánková, Blanka (referee)
Female homosexuality is a complex phenomenon, and therefore, the causes of the emergence of female homosexuality are the subject of extensive debates. There are various theories about the origin of female homosexuality, and one of them is the neurohormonal theory. The neurohormonal theory assumes that the organizational effects of prenatal hormones in the early stages of development influence sexual orientation. Congenital adrenal hyperplasia (CAH) is a condition in which affected women are exposed to high levels of prenatal hormones. In women with CAH, a higher frequency of homosexual and bisexual orientation is observed compared to the general population. The effects of prenatal hormones can explain this. However, most women with CAH are still heterosexual, and there is also a significant number of lesbian and bisexual women who do not have any disorder. This also suggests that hormones are certainly not the sole factor contributing to the development of homosexual orientation. Keywords: female homosexuality, neurohormonal theory, organizational-activational hypothesis, congenital adrenal hyperplasia, disorders of sexual development.
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Auxological aspects in patients with congenital adrenal hyperplasia.
Petzoldová, Barbora ; Sedlak, Petr (advisor) ; Hníková, Olga (referee)
Congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency is the most common inherited endocrinopathy. This disorder is associated with many complications caused either by illness itself or inadequate treatment. The late consequence of this disorder is a reduced final height. Absences of cortisol, androgen excess, with or without salt wasting, virilization of external genitalia in new-born girls are main findings. Androgen excess causes virilization in girls, accelerated bone maturation and early epiphyseal fusion in both sexes. CAH patients are dependent on lifelong treatment with oral glucocorticoids. Growth retardation and obesity are common side effects resulting from glucocorticoid use. The aim of this thesis was to analyse the success of obtaining a final height that is within a genetic potential regarding to treatment compliance. The other objective was the analysis of auxological profile of CAH patients. This study was mainly focused on the analysis of body height, linear proportionality, the weight parameters, body composition, body fat distribution, skeletal robusticity and body structure. In this study we performed anthropometric examination of 30 CAH patients. 25 of them had completed growth (age: 16,4 to 44,5 years), 12 woman and 11 men and 2 men with karyotype 46XX....
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