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Simple Recommender System
Gorčák, Damián ; Rychlý, Marek (referee) ; Bartík, Vladimír (advisor)
Recommender systems are very important in searching for items all over the internet. There are many algorithms for creating recommendations. The main goal of this thesis was to find suitable datasets and make application, which would process them. After that, chosen algorithms for recommender systems are compared with selected datasets
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Case Study of a Physiotherapy Treatment of a Patient with Amyotrophic Lateral Sclerosis
Pešková, Laura ; Novotná, Irena (advisor) ; Hamouzová, Dita (referee)
v Abstract Author: Laura Pešková Supervisor: Mgr. Irena Novotná Title: Case study of a physiotherapy treatment of a patient with amyotrophic lateral sclerosis Objectives: The aim of this bachelor thesis is to summarize the theoretical knowledge about the diagnosis of amyotrophic lateral sclerosis, about the possibilities of therapy and to elaborate a case study of physiotherapy treatment of a patient with this diagnosis. Methods: The thesis is divided into two parts - a general part and a special part. The general part is focused on the summary of theoretical knowledge about amyotrophic lateral sclerosis. This part includes chapters of neuroanatomy, general characteristics and clinical picture of the disease, possibilities of diagnostic and therapeutic procedures. The special part includes initial kinesiological examination, design of short-term and long-term physiotherapy plan, description of therapeutic units, output kinesiological examination and evaluation of the effect of therapy. Results: Positive outcomes of the physiotherapy intervention include increased range of motion, improved gait stability and training in independent verticalization. The therapy failed to affect muscle tone and spasticity. All results of the work are presented in the chapter on the effect of therapy. Conclusion: The above case...
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ALS application in the landscape protection of protected heritage zone in Kremnica
Miňo,Martin ; Dědič, Peter ; Flórová, Mária ; Lieskovský, Tibor
Kremnica was an important mining town in the kingdom. Because of the gold mining it has become since the Middle Ages the seat of the royal mint, which works until today. The mint is the last of the working components with the exception of minor mining in the Andrej shaft upon which the economy and the importance of the town were built. The remnants of the mining activities went through the process of natural succession and blended into the wooded landscape. Despite the area is a protected heritage zone since 1999 its valuable landscape components were not sufficiently known and protected because of broken topography and natural succession. It became visible among others in the way the border of the heritage zone was established. In several places it leaves valuable relicts without protection. Slovakia's landscape is gradually airborne laser scanned (ALS). The source data allow to create a digital surface model (DMP) in very high resolution, which is 4 times higher than most of the commonly available data. DMP is visualized by a specialized workflow highlighting relics of cultural heritage. Full-area ALS of Slovak landscape came just when the regulations of the protected heritage zone needed to be updated. This facilitated the configuration of a new assessment approach for this site using a combination of LLS interpretation, historical maps and field surveys. For presentation and practical use of state administration a practical GIS model was created and an interactive 3D model of the area is being prepared as an important tool mainly for consideration of new building inputs in the protected zone.
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Forest monitoring using the GEDI sensor
Šedová, Adéla ; Potůčková, Markéta (advisor) ; Moudrý, Vítězslav (referee)
The overall objective of this thesis was to explore the use of GEDI and its integration with Airborne Laser Scanning (ALS) for large scale forest monitoring. The study was carried out using a sample of GEDI footprints that fell into the timeline of three available ALS datasets that were acquired during the same year. The study area, located in Southeast of Czechia, is covered with mature 121-year-old forest monoculture of Norway spruce (Picea abies), and due to frequent disturbances caused by infestation is closely monitored as a part of research on forest dynamic. As a result, the forest is highly fragmented, and due to its dynamic character, close dates of acquisitions were preferred to a larger dataset. Canopy gaps and low tree densities are known to pose a challenge for large-footprint full-waveform LiDARs. The specific of GEDI sensor, such as its footprint size, were specially designed to overcome these challenges. The options of optimising GEDI's geolocation accuracy were explored. A tool for integrating GEDI and ALS data, the GEDI Simulator, was used to standardise both data sources and derive elevation height, Relative Height (RH) and Canopy Cover Fraction (CCF). The metrics were derived from real GEDI waveforms, simulated GEDI-like waveforms, and calculated from the ALS point cloud, and...
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Simple Recommender System
Gorčák, Damián ; Rychlý, Marek (referee) ; Bartík, Vladimír (advisor)
Recommender systems are very important in searching for items all over the internet. There are many algorithms for creating recommendations. The main goal of this thesis was to find suitable datasets and make application, which would process them. After that, chosen algorithms for recommender systems are compared with selected datasets
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The use of induced pluripotent stem cells in the treatment of spinal cord injury and ALS.
Gajdoš, Roman ; Jendelová, Pavla (advisor) ; Vargová, Lýdia (referee)
Induced pluripotent stem cells (iPSCs) have become a new phenomenon of regenerative medicine. It is obvious that they share some common characteristics with embryonic stem cells (ESCs) such as stemness potential, self-renewal p., differentiation p. iPSCs retain their epigenetic memory, allowing becoming patient-specific and so it is not necessary to apply immunosuppressants. The use of ESCs is controversial, because their acquisition is associated with embryo destruction. As a cell source for iPSCs derivation we can use any somatic cells, however, fibroblasts are preferably used due to their easy availability. With transcriptional reprogramming cocktail (OCT4, SOX2, KLF4, c- MYC / OCT4, SOX2, NANOG, LIN28) we can obtain required iPSCs line, which is then further differentiated into neural precursors (NPCs). These cells can be grafted into lesion site, where they can facilitate regeneration by several mechanisms (cell replacement, protective effect, facilitation the expression of trophic factors). Nevertheless, here we are still dealing with the risk of tumorogenesis or low cell derivation efficiency that limits the use of iPSCs in clinical practice. In this thesis we will therefore mainly focus on the therapeutic potential of iPSCs in preclinical studies, their use in the treatment of...
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Huntington's disease modeling and stem cell therapy in spinal cord disorders and injury
Hruška-Plocháň, Marián ; Motlík, Jan (advisor) ; Bjarkam, Carsten (referee) ; Roth, Jan (referee)
Neurological disorders affect more than 14% of the population worldwide and together with traumatic brain and spinal cord injuries represent major health, public and economic burden of the society. Incidence of inherited and idiopathic neurodegenerative disorders and acute CNS injuries is growing globally while neuroscience society is being challenged by numerous unanswered questions. Therefore, research of the CNS disorders is essential. Since animal models of the CNS diseases and injuries represent the key step in the conversion of the basic research to the clinics, we focused our work on generation of new animal models and on their use in pre-clinical research. We generated and characterized transgenic minipig model of Huntington's disease (HD) which represents the only successful establishment of a transgenic model of HD in minipig which should be valuable for testing of long term safety of HD therapeutics. Next, we crossed the well characterized R6/2 mouse HD model with the gad mouse model which lacks the expression of UCHL1 which led to results that support the theory of "protective" role of mutant huntingtin aggregates and suggest that UCHL1 function(s) may be affected in HD disturbing certain branches of Ubiquitin Proteasome System. Traumatic spinal cord injury and Amyotrophic Lateral...
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Application of Diffusion Tensor Imaging to Brain Gray and White Marker
Rulseh, Aaron Michael ; Vymazal, Josef (advisor) ; Hluštík, Petr (referee) ; Hájek, Milan (referee)
Application of Diffusion Tensor Imaging to Brain Gray and White Ma er A In the present work we explore the gray and white ma er applicability of diffusion tensor imaging (DTI). To evaluate effect of ferritin-bound iron on gray ma er contrast in DTI, we created an in vitro model consisting of agarose gel phantoms doped with ferritin, and validated our results in vivo on healthy volunteer subjects - years of age in the basal ganglia. We further explored the application of DTI to amyotrophic lateral sclerosis (ALS) and multiple system atrophy (MSA); neurodegenerative diseases with gray and white ma er pathophysiological components. In the ALS study, patients and age- and sex-matched controls were recruited, while the MSA study included probable MSA subjects ( MSA-P, MSA-C) and age- and sex-matched controls. We found that ferritin-bound iron may make a signi cant contribution to DTI scalars in gray ma er regions of the brain, mediated by eigenvalue repulsion. is has important implications for DTI studies targeting gray ma er regions, especially in adolescence and in diseases associated with altered brain-iron load. In ALS, we found altered diffusion in the corona radiata and callosal body, and changes in R in the caudate nucleus and frontal white ma er. In MSA, we observed widespread white ma er changes associated...
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Physiotherapy in patients with amyotrophic lateral sclerosis
Dobešová, Petra ; Šebek, Milan (advisor) ; Šebková, Natálie (referee)
BACHELOR THESIS ABSTRACT Title: Physiotherapy in patients with amyotrophic lateral sclerosis Abstract: This bachelor thesis is consisting of a theoretical part and a practical part. The theoretical part is consisting of the basics of neuroanatomy needed to understand the disease, pathophysiology of amyotrophic lateral sclerosis (ALS) and clarify the term motor neuron disease. Then is the ALS described in more details, talks about its history, epidemiology, aetiology, diagnosis, clinical manifestation, classification, treatment and palliative care in patients with ALS. In terms of physiotherapy is first described the course of physiotherapy in the 6 stages of ALS. Subsequently, specific physiotherapeutic techniques are described, which are used in therapy with a justification of what we can influence with their help. The described techniques are respiratory physiotherapy, active exercise, dynamic neuromuscular stabilization, passive exercise and the possibility of influencing pain through physiotherapy. The practical part is consisting of an information brochure for patients with ALS in the 1st and 2nd stage of the disease and a case report of a patient in the late phase of ALS. The brochure is containing basic information about the disease and the possibilities of movement and exercise with the...
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Modelovanie ochorenia a štúdium regeneračných procesov v Huntingtonovej chorobe a ALS in vivo
Hruška-Plocháň, Marián
Neurological disorders affect more than 14% of the population worldwide and together with traumatic brain and spinal cord injuries represent major health, public and economic burden of the society. Incidence of inherited and idiopathic neurodegenerative disorders and acute CNS injuries is growing globally while neuroscience society is being challenged by numerous unanswered questions. Therefore, research of the CNS disorders is essential. Since animal models of the CNS diseases and injuries represent the key step in the conversion of the basic research to the clinics, we focused our work on generation of new animal models and on their use in pre-clinical research. We generated and characterized transgenic minipig model of Huntington's disease (HD) which represents the only successful establishment of a transgenic model of HD in minipig which should be valuable for testing of long term safety of HD therapeutics. Next, we crossed the well characterized R6/2 mouse HD model with the gad mouse model which lacks the expression of UCHL1 which led to results that support the theory of "protective" role of mutant huntingtin aggregates and suggest that UCHL1 function(s) may be affected in HD disturbing certain branches of Ubiquitin Proteasome System. Traumatic spinal cord injury and Amyotrophic Lateral...
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