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Let There Be Light? Impact of Light Pollution on the Environment
Svoboda, Lukáš ; Mihai, Hana (referee) ; Ellederová, Eva (advisor)
Světelné znečištění patří mezi mnoho druhů znečištění, které ohrožují naši planetu. Důvod jeho vzniku je vedlejší efekt průmyslové civilizace a jeho negativní dopad ohrožuje lidské zdraví, zvěř, rostlinstvo a klima. Cílem této bakalářské práce je vymezit koncept světelného znečištění, popsat způsoby měření a negativní dopady. Teoretická část bakalářské práce se zabývá definováním pojmu světelného znečištění a popisuje způsoby, jakými se světelné znečištění projevuje. Dále řeší možnosti měření světelného znečištění, a také diskutuje negativními dopady na lidské zdraví, přírodu, ekonomiku, bezpečnost a astronomii. Navazující kapitola popisuje parametry běžně užívaných světelných zdrojů pro veřejné osvětlení, a nakonec jsou probírány základní praktiky, které napomáhají snížit světelné znečištění a jsou doplněny příklady správně navrženými svítidly pro venkovní osvětlení. Praktická část této bakalářské práce se zabývá kvantitativním výzkumem, který měl za cíl objasnit úroveň povědomí o světelném znečištění mezi širokou veřejností. Data pro tento výzkum byla shromážděna pomocí dotazníkového šetření.
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Depiction of side effects of Covid-19 vaccines in Czech television news
Zelbová, Judita ; Klabíková Rábová, Tereza (advisor) ; Křeček, Jan (referee)
This thesis focuses on how the side effects of vaccination against covid-19 were presented by media during the pandemic. The aim was to find out how the side effects were reported by Czech national television stations in their evening news programmes, what were the differences in presentation between the stations and which experts were invited to comment on the topic. The thesis primarily uses qualitative content analysis and to a lesser degree quantitative content analysis. The thesis shows that three of the four TV stations studied (ČT1, Nova and Prima) approached the presentation of the topic in a very similar way conceptually, TV Barrandov being quite different in this respect. All TV stations presented side effects on the basis of substantiated data, with an emphasis on information obtained from relevant organisations (European Medicines Agency, Czech State Institute for Drug Control) and experts (mostly epidemiologists, immunologists and physicians of various specialties). Contrary to the expectation, the coverage of the side-effects proved to be relatively marginal and only became notable in the spring of 2021, when a larger number of adverse reactions occurred with the AstraZeneca vaccine.
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Endocrine disruptors as ligands of nuclear receptors.
Tóthová, Veronika ; Pávek, Petr (advisor) ; Jirkovský, Eduard (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Student: Veronika Tóthová Supervisor: prof. PharmDr. Petr Pávek, Ph.D. Title of diploma thesis: Endocrine disruptors as ligands of nuclear receptors Endocrine disruptors are synthetic substances used in many areas of industry or agriculture that negatively affect and interfere with the functions of the endocrine system. Their negative effects have been mentioned since the beginning of the 20th century, but only recently have more attention been paid to them due to their adverse effects on the human organism and the environment. In the thesis, we summarized the mechanisms of action of the most well-known endocrine disruptors on selected nuclear receptors. Specifically, it was bisphenol A and phthalate-type compounds. From nuclear receptors, we focused on PPAR (Peroxisome Proliferator-Activated Receptors), Pregnane X receptor (PXR) and Aryl androstane receptor (AHR). From the information obtained, it follows that we are in constant contact with these substances, and therefore we should devote more attention to studying their effects, because not all mechanisms of action and effects of these compounds are completely known. In this way, we could increase the safety of using these substances,...
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The role of chemotherapy, hormonal and biological treatment in breast cancer therapy
BOUCHALOVÁ, Linda
The bachelor thesis deals with the pharmacological treatment of breast cancer. Breast tumours are the most common cancer in women in the Czech Republic, therefore, in the introduction attention is paid to its incidence and mortality. Furthermore, the theo-retical part of the thesis briefly describes the basics of breast anatomy and physiology, explains the differences between benign and malignant breast tumours and also fo-cuses on the origin and diagnosis of this disease. The chapter on systemic treatment describes the main topic of the thesis - pharmacological therapy of breast cancer, inc-luding chemotherapeutic, hormonal and biological treatment. The aim of the bachelor thesis was to determine the level of patients' awareness of the possible risks of pharmacological treatment. The actual side effects of the treatment are described in the theoretical part of the thesis.
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Radiotherapy and skin care
NOVÁKOVÁ, Karolína
The bachelor thesis on the topic "Radiotherapy and skin care" deals with the adverse effects of ionizing radiation on the skin in the context of radiotherapy and how to care for the irradiated skin in terms of prevention of these adverse effects. The aim of the thesis was to describe the principle of radiotherapy and its effect on the human body, especially on irradiated areas of the skin, which may be more susceptible to adverse effects. The thesis is divided into theoretical and practical parts and is divided into 6 chapters. The theoretical part focuses on the principles of radiotherapy, the adverse effects of ionizing radiation, specifically the adverse effects on irradiated skin and the possibilities of skin care. The practical part of the thesis deals with a questionnaire survey. The research design of the thesis was carried out by means of a questionnaire survey among cancer patients. The questionnaire was designed in a semi-structured form and then statistically processed. The results obtained from the questionnaire survey provide information on the level of awareness of cancer patients about the side effects of radiotherapy, their correct or sufficient instruction about the side effects, and their knowledge of proper care of irradiated skin to prevent radiation damage or to mitigate the effects of adverse effects on irradiated skin. The results of this work can be used as study material for radiology assistants and medical students to add to their professional knowledge of the effects of radiotherapy on the skin, or can also serve to streamline the process of providing information on the care of irradiated skin.
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Hormonal Contraception - Users'Knowledge
Křiklánová, Jana ; Marešová, Helena (advisor) ; Pokladníková, Jitka (referee)
HORMONAL CONTRACEPTION - USERS̕ KNOWLEDGE Student: Křiklánová, J. Tutor: Marešová, H. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University, Czech Republic Introduction: Hormonal contraception is a broadly used and very reliable birth control method. Nonetheless, it is not entirely risk-free. This thesis deals with the awareness of those risks in women who are currently using hormonal contraception or have ever used it before. Aim of the thesis: The main aim was to determine the extent of the users' awareness of hormonal contraception and its risks, undesirable side effects and contraindications, as well as their source of information. Furthermore, the awareness of the environmental impact, the reasons for using hormonal contraception and user satisfaction were examined. Methodology: The research was carried out by means of online questionnaires, which were spread among current or former users of hormonal contraception regardless of age, educational background or place of residence. 148 completed questionnaires were gathered and the data which were obtained were statistically evaluated. Results: It was discovered that women feel informed (25 %) or rather informed (44,6 %) more often than uninformed; the most frequent source of information is patient...
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Recent knowledge on drug effect on male fertility
Klapková, Tereza ; Trejtnar, František (advisor) ; Hyršová, Lucie (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Candidate: Tereza Klapková Supervisor: Assoc. Prof. PharmDr. František Trejtnar, CSc. Title of diploma thesis: Recent knowledge on drug effect on male fertility Among the various types of side effects presented in clinically used drugs, negative effects on male reproductive functions can be find. This issue seems to be important and current especially due to the general trend of the decrease in fertility in men and the increasing drug use in younger age groups. The aim of this diploma thesis was to create an overview summarizing current expert knowledge on the effect of drugs on male fertility. For this purpose, we selected relevant publications in the PubMed database, perform their analysis and create the text ofthe thesis. The review focuses mainly on groups of drugs that are often clinically used and discussed in relation to male fertility, such as drugs acting on the cardiovascular system, antimicrobial drugs, drugs used in pain therapy, antidepressants, antiepileptics, antipsychotics, immunosuppressants and some other drugs. In addition to standard drugs, the review also includes several important natural substances, which are used as adjunctive therapy of various diseases or are important from a...
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Let There Be Light? Impact of Light Pollution on the Environment
Svoboda, Lukáš ; Mihai, Hana (referee) ; Ellederová, Eva (advisor)
Světelné znečištění patří mezi mnoho druhů znečištění, které ohrožují naši planetu. Důvod jeho vzniku je vedlejší efekt průmyslové civilizace a jeho negativní dopad ohrožuje lidské zdraví, zvěř, rostlinstvo a klima. Cílem této bakalářské práce je vymezit koncept světelného znečištění, popsat způsoby měření a negativní dopady. Teoretická část bakalářské práce se zabývá definováním pojmu světelného znečištění a popisuje způsoby, jakými se světelné znečištění projevuje. Dále řeší možnosti měření světelného znečištění, a také diskutuje negativními dopady na lidské zdraví, přírodu, ekonomiku, bezpečnost a astronomii. Navazující kapitola popisuje parametry běžně užívaných světelných zdrojů pro veřejné osvětlení, a nakonec jsou probírány základní praktiky, které napomáhají snížit světelné znečištění a jsou doplněny příklady správně navrženými svítidly pro venkovní osvětlení. Praktická část této bakalářské práce se zabývá kvantitativním výzkumem, který měl za cíl objasnit úroveň povědomí o světelném znečištění mezi širokou veřejností. Data pro tento výzkum byla shromážděna pomocí dotazníkového šetření.
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Hormonal Contraception - Users'Knowledge
Křiklánová, Jana ; Marešová, Helena (advisor) ; Pokladníková, Jitka (referee)
HORMONAL CONTRACEPTION - USERS̕ KNOWLEDGE Student: Křiklánová, J. Tutor: Marešová, H. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University, Czech Republic Introduction: Hormonal contraception is a broadly used and very reliable birth control method. Nonetheless, it is not entirely risk-free. This thesis deals with the awareness of those risks in women who are currently using hormonal contraception or have ever used it before. Aim of the thesis: The main aim was to determine the extent of the users' awareness of hormonal contraception and its risks, undesirable side effects and contraindications, as well as their source of information. Furthermore, the awareness of the environmental impact, the reasons for using hormonal contraception and user satisfaction were examined. Methodology: The research was carried out by means of online questionnaires, which were spread among current or former users of hormonal contraception regardless of age, educational background or place of residence. 148 completed questionnaires were gathered and the data which were obtained were statistically evaluated. Results: It was discovered that women feel informed (25 %) or rather informed (44,6 %) more often than uninformed; the most frequent source of information is patient...
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Assessment of degradation of coatings for cement composites with organic fillers due to aggressive environments
Pernicová, Kateřina ; Vacula, Miroslav (referee) ; Bydžovský, Jiří (advisor)
There are many methods and techniques for assessing the degradation rate of coatings for cement composites with organic fillers. However, it is necessary to choose appropriate combination of various adverse conditions including intensity level of corrosive media and duration of action of these compounds on the material to simulate their complex effect in relation to the real exposure of structures. Part of the theoretical work is focused on the kinds of coatings that are suitable for cement composites with organic fillers and then there are listed devaluing environments which these coatings affect. There is also a proposal for a testing a complex simulation of a real environment. The practical part describes the tests that were performed on cement bonded particleboards with applied coatings.
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