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Protein Structure Prediction
Tuček, Jaroslav ; Martínek, Tomáš (referee) ; Burgetová, Ivana (advisor)
This work describes the three dimensional structure of protein molecules and biological databases used to store information about this structure or its hierarchical classification. Current methods of computational structure prediction are overviewed with an emphasis on comparative modeling. This particular method is also implemented in a proof-of-concept program and finally, the implementation is analysed.
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Vlivy působící na kvalitu a složení bazénových vzorků mléka u dojnic českého strakatého skotu v konkrétním chovu
Strnadová, Jitka
The aim of the diploma thesis was to evaluate the influences on the quality and composition of bulk milk samples of dairy cows of Czech spotted cattle. The observation took place within one calendar year (January to December 2022) in the selected breeding of GenAgro Říčany a.s., when we took a total of 52 milk samples. The obtained samples were analyzed and, together with the data from the temperature-humidity sensors (HOBO), sorted in the Microsoft Excel program and subsequently evaluated in the STATISTICA 14.0 program. The highest number of somatic cells (SB) in milk was in the summer, while the lowest in the winter and spring (P < 0,05). The highest number of SB was in the temperature zone at 20.1 °C and the lowest at 0 °C (P < 0,05). The highest number of SB was found in the period with the highest average lactation order (P < 0,05). Regarding the influence of lactation phase, it was found that the highest number of SB was found in dairy cows in the period with the highest average lactation phase (P < 0,05). No significant differences (P > 0,05) were found for the other milk productivity parameters. Over the entire follow-up, the freezing point averaged -0,552°C in all cases.
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Vliv teploty vzduchu ve stáji na parametry mléčné užitkovosti dojnic českého strakatého skotu v konkrétním chovu
Hanáková, Šárka
The aim of this thesis is to analyse the effect of air temperature on milk yield parameters of dairy cattle in a specific breeding system. The milk yield parameters included milk yield (kg milk), lactation order (n), lactation phase (days) and milk components content (% fat and % protein). The observations were carried out between January and December 2022. Data on milk yield parameters were obtained from the results of the Performance Check (PC). A total of 7 863 individual cases (dairy cows) were evaluated. During the monitoring period, air tem-perature in the stable (°C), relative humidity (%) were collected using a temperature-humidity sensor (HOBO). The results showed that temperature had no statistically significant effect on milk yield, lactation stage and lactation sequence. On the other hand, there were significant differences in the content of milk components, which were fat and protein (P < 0.01). In the case of relative humidity, there was a statistically significant effect on milk yield, where milk yield decreased with increasing values of relative humidity in the cows studied (P < 0.01). Relative humidity also influenced fat and protein content (P < 0.01). In the case of THI, there were no statistically significant differences in milk yield, lactation order and lactation phase (P > 0.05), but statistically significant differences were found for milk components (P < 0.01).
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Nové trendy v konzervaci objemných krmiv a jejich vliv na produkci mléka dojnic
DOUBEK, Martin
Cow's milk plays an important role in human nutrition and is one of the main products of the dairy industry. Its composition changes in response to various factors including forage. The quality of roughage is one of the important aspects for the nutrition and health of dairy cows and milk productivity itself. The aim of the diploma thesis was to assess two forages, grass hay and rye hay, and their effect on milk yield. Along with milk yield, the amount of protein and fat in milk was assessed. Feed rations at the VOD Kadov company were compared over the course of four years. Based on documented data from the company VOD Kadov, according to statistical calculations, the influence of rye haying (p 0,05) on increasing milk yield was not confirmed, and no influence on the amount of fat in milk was proven either(p 0,05). The effect of rye silage on the amount of protein in milk was proven by statistical calculation (p 0,05). The results show that feeding high-quality grass forage or high-quality rye forage has no independent effect on milk yield or fat content. Rye haylage is a suitable substitute for grass haylage in the feed ration.
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Zhodnocení vztahu kvantitativních a kvalitativních parametrů mléčné užitkovosti dojnic holštýnského plemene v konkrétním chovu
Poláčková, Pavlína
The aim of this bachelor’s study was to evaluate an effect between quantitative and qualitative parameters of milk efficiency. As a quantitative parameter was used milk yield. Observed properties from qualitative compounds were fat, protein, lactose, somatic cells and carbamide. To the problem was processed review of literature. Evaluation was realised in cooperative farm AGROS Vyškov-Dědice which deals with breeding of the Holstein breed with average efficiency 35 kg milk per day. Dates of milk efficiency were taken from the control efficiency and afterwards putted through analysis in MS Excel. It has been found that with rising milk yield was increase fat and also protein content which is not common in our farms and it is contrary to commonly stated literature or other authors. Reversely lactose had been evaluated rather indirect impact – the lactose content decreased with increasing milk yield. No correlation was found for somatic cells and carbamide with milk yield.
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Stanovení kvalitativních parametrů dojeného mléka indikující zdravotní stav dojnic
PROKOP, Daniel
When only automatic systems are used for milking milk, it is essential to evaluate the quality of the milk, preferably in real-time, to maintain the high quality of the products and at the same time to detect health problems in the dairy cow in good time. By early detection of a dairy cow's health problem, which a change in milk quality can detect, it is also possible to reduce the cost of its treatment and eliminate financial losses du ring a period when we cannot monetize milk. To effectively evaluate the quality of milked milk, it is appropriate to monitor the following parameters: somatic cell count, conductivity, fat, protein, lactose, and urea content. The bachelor's thesis presents the levels of the quantities mentioned above, which indicate changes in the quality of milked milk, internal and external influences that affect them, as well as methods for their detection and evaluation
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Biophysical characterization of the CAR/RXR protein complex with its binding partners
Duchoslav, Vojtěch ; Bouřa, Evžen (advisor) ; Pavlíček, Jiří (referee)
The constitutive androstane receptor (CAR) plays an important role as a xenosensor in the organism and is therefore widely expressed in the kidney, liver, gallbladder and in the small intestine epithelium, where the biotransformation of xenobiotic occurs. CAR is also an important factor in the elimination of bile acids and bilirubin. CAR has also been shown to have an important role in regulation of glucose and lipid metabolism. Impairment of lipid and glucose metabolism is a common cause of cardiovascular and metabolic diseases such as atherosclerosis, type 2 diabetes, obesity and insulin resistance. These diseases are called metabolic syndrome and result in severe organ damage. CAR respective its complex with RXRα (retinoid X receptor α) has become a promising biological target for drug discovery for metabolic syndrome. The major aim of this study was a structural characterization of the CAR/RXRα protein complex together with the agonist IV676*HCl, which would describe in detail the interaction of this small molecule with the receptor. Obtained structural information would be used to design improved agonists.
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Protein Structure Prediction
Tuček, Jaroslav ; Martínek, Tomáš (referee) ; Burgetová, Ivana (advisor)
This work describes the three dimensional structure of protein molecules and biological databases used to store information about this structure or its hierarchical classification. Current methods of computational structure prediction are overviewed with an emphasis on comparative modeling. This particular method is also implemented in a proof-of-concept program and finally, the implementation is analysed.
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