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Atorvastatin and its effect on the atherogenic process in genetically / / modified mouse model of atherosclerosis I
Kozáková, Hedvika ; Nachtigal, Petr (advisor) ; Semecký, Vladimír (referee)
CHARLES UNIVERSITY IN PRAGUE FACULTY OF PHARMACY IN HRADEC KRÁLOVÉ Department of Biological and Medical Sciences Rigorous Thesis - Abstract Mgr. Hedvika Kozáková 2007 Atorvastatin and its effects on atherogenic process in the genetically modified mouse model of atherosclerosis I Statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) represents golden standard in dyslipidemia treatment in humans. However, its effects in animal models of atherosclerosis are very inconsistent. Thus, the aim of this study was to evaluate whether statins has hypolipidemic and inflammatory effects in apoE/LDLR deficient mouse model of atherosclerosis. The aim of this rigorous thesis was to verify whether atorvastatin posses similar effects in apoE/LDL receptor double knockout mice that are common in human medicine. Female ApoE/LDL receptor-double-knockout mice at 8 weeks of age were randomly divided into 2 groups. The control group of animals (n=8) was fed with the atherogenic (western type) diet for another 8 weeks. The same atherogenic diet and treatment period was used in other two groups where atorvastatin was added to the diet at the dosage of 100 mg/kg per day. Biochemical analysis of blood cholesterol fractions, ELISA analysis of monocyte chemoattractant protein-1, vascular cell adhesion molecule-1 levels in...
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