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Cardiovascular risc factors and complications associated with atherosclerosis - their prevalence and control in seniors in the EUROAGEISM H2020 project
Kubíková, Veronika ; Fialová, Daniela (advisor) ; Kostřiba, Jan (referee)
INTRODUCTION Cardiovascular diseases (CVD) are currently on the first place among the causes of death worldwide and also in the Czech Republic (CR). The most common causes of death among CVDs are disorders associated with atherosclerosis (ATS) and the prevalence of atherosclerosis and their complications increases with increasing age. The aim of this diploma thesis was to document CVS morbidity in geriatric patients in the sample of FIP7 program of the EUROAGEISM H2020 project, mainly the prevalence of CVS disorders associated with ATS, and to evaluate the controll of risk factors associatedwith general risks of progression of ATS. METHODS The data collection for this theses was carried out in the CR from September 2018 to January 2019 in patients in acute care at the age of 65 and older at geriatric wards in Hradec Králové (HK) and Brno. Patients involved in the study were those admitted to hospitalization at the time of data collection, were complying with inclusion criteria and undersigned the informed consent. The Ethics committee of the Faculy of Pharmacy, Charles University and ethics committee of participating healthcare facilities approved the project. Information have been obtained using the questionnaire for comprehensive geriatric assessment which is the secured instrument of the...
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Analysis of Marketing Strategies of Pharmacies
Mikulcová, Jitka ; Kostřiba, Jan (advisor) ; Pokladníková, Jitka (referee)
The theoretical part of this diploma thesis defines basic terms related to the marketing and gives a general overview of marketing strategies. It also evaluates the importance of marketing in public health services and describes possibilities of internet health technologies that patients use for the contact with health professionals and getting information about health. The practical part analyzes patients' opinion on pharmacy marketing practice and importance of internet communication. Data were collected via the questionnaire survey among the users of internet and Facebook and customers in one independent community pharmacy in Beroun. Practical part also refers about the experimental marketing campaign that was performed in the pharmacy in Beroun and that focused on the creating promotion materials and technologies of internet communication. According to results, many patients appreciate marketing activities of community pharmacies. There is also noticeable a positive trend of using the web sites and social media to connect with the community pharmacy. Key words: marketing, healthcare, community pharmacy, internet, social media, the Czech Republic
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Analysis of the Dispensing Care Provided by Pharmacies in Hradec Kralove
Ličková, Aneta ; Kostřiba, Jan (advisor) ; Pokladníková, Jitka (referee)
Analysis of the Dispensing Care Provided by Pharmacies in Hradec Kralove Author: Aneta Ličková Supervisor: PharmDr. Jan Kostřiba, Ph.D. Charles University, Faculty of Pharmacy, Hradec Kralove Department of Social and Clinical Pharmacy Introduction: Nowadays, a high professional level of dispensing activities is an indispensable prerequisite for the proper work of a pharmacist. A pharmacist is also very often the last link in the chain of healthcare professionals involved in the treatment of a patient and thus has a unique opportunity to detect any potential errors or risk of a given therapy. Regarding the self- medication, the pharmacist is often the only person, with whom the patient consults his therapy. Objective: The aim of this thesis is to analyse dispensing activities provided by pharmacies in Hradec Kralove. Methodology: Analysis of a dispensing activity of a prescription-only drug and over-the- counter product. The list of pharmacies was identified through the SÚKL database. The data collected during the visits were from the 32 pharmacies in total. The data collection tool was mystery shopping that followed thoroughly prepared scenario. The customer was a 26-year-old woman in the 10th week of pregnancy who had come up to pharmacies with a prescription for tetracycline antibiotics and she...
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Pharmacovigilance: Drug regulation development and legislation overview.
Manišová, Michaela ; Kostřiba, Jan (advisor) ; Zimčíková, Eva (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Social and Clinical Pharmacy Candidate Mgr. Michaela Manišová Consultant PharmDr. Jan Kostřiba, Ph.D. Title of Thesis Pharmacovigilance: Drug regulation development and legislation overview. Introduction: Pharmacovigilance is a scientific discipline relating to the detection and evaluation of adverse drug reactions and other risks associated with the use of the medicinal products after marketing authorisation and implementation of the risk minimisation measures. Objectives: To analyze the legislation requirements in the area of pharmacovigilance for the medicinal products for human use in the European Union and their implementation in practice. Trends in adverse drug reactions reporting in the various pharmacovigilance systems (United States, Czech Republic, European Union), evaluation of the factors affecting reporting and the main benefits of spontaneous reporting. Methods: The legal requirements of the European Union, the Czech Republic and the United States was used as the source of information, followed by the official website of the Drug Regulatory Authorities, the best practices guidelines prepared by the European Medicines Agency and by the Food and Drug Administration, the harmonization guidelines issued by...
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Analysis of Pharmacy Economy in the Hradec Králové Region
Lepšová, Nikol ; Kostřiba, Jan (advisor) ; Zimčíková, Eva (referee)
Charles University, Faculty of Pharmacy in Hradec Kralove Department of: Social and Clinical Pharmacy Author: Nikol Švorcová Supervisor: PharmDr. Jan Kostřiba, Ph.D. Title of Diploma Thesis: Analysis of Pharmacy Economy in the Hradec Kralove Region Introduction: The economy of pharmacies in the Czech republic is currently being discussed topic mainly due to the growth pharmacies belonging to chains. Within a few years there have been many highly discussed changes that have changed the pharmacy market and its character. Large companies, which operates a lot of pharmacies was established and these companies quickly increase number of their pharmacies. This has led to the emergence of so-called virtual chains, which help many private entrepreneurs in this area to maintain competitiveness. Between 2008 and 2015 was economy of pharmacies influenced by regulatory fees. The biggest problem of last years is the closure of pharmacies in smaller municipalities, which reduces the availability of pharmaceutical care. The Ministry of Health and the Czech Chamber of Pharmacists are finding a solution to these problems. Objectives: The aim of this diploma thesis is to evaluate the total financial health of selected pharmacies of the Hradec Kralove Region using methods of financial analysis based on a calculation...
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Pharmacovigilance of active substance zolpidem
Vorel, Roman ; Kostřiba, Jan (advisor) ; Zimčíková, Eva (referee)
Charles University, Faculty of Pharmacy in Hradci Králové Department of: Social and Clinical Pharmacy Author: Roman Vorel Supervisor: PharmDr. Jan Kostřiba, Ph.D. Title of Diploma Thesis: Pharmacovigilance of active substance zolpidem Introduction: Drug safety became very important topic in the second half of 20th century, even beyond pharmacy. It relates to increasing impact on testing of drugs before launch onto the market, but also following monitoring, so the benefit and risk ratio of drug can be determined. Pharmacovigilance takes care of monitoring of drug use risk. Zolpidem is active substance from class hypnotics and it is used for short-term treatment of insomnia. Most professionals recommend zolpidem as first line treatment of acute insomnia. That is why it can be considered as one of the most important hypnotic drugs. Objectives: The aim of this diploma thesis is to analyze spontaneous reports for adverse drug reaction for zolpidem from years 2004 to 2017. The thesis focus on reports from the Czech republic but also from the whole world. The information in SPC of medicinal products containing zolpidem which were distributed from 2004 to 2017 are compared. Methods: Following data from years 2004 to 2017 were used: 1) List of spontaneous reports for adverse reaction from the Czech republic...
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Evaluation of potentially inappropriate drugs and drug procedures in the old age (I.)
Krivošová, Michaela ; Fialová, Daniela (advisor) ; Kostřiba, Jan (referee)
Introduction: Proportion of the population over the age of 65 is continuously increasing in the European Union, and therefore, the number of polymorbid patients with polypharmacy, limited functional capacities and syndrome of geriatric frailty is rising every year as well. In order to support the quality of geriatric prescribing and to lower possible adverse drug events, explicit criteria for potentially inappropriate drugs and drug procedures for elderly have been created. The aim of the diploma thesis was to evaluate how many potentially inappropriate medications (PIMs) for elderly out of 22 explicit criteria were registered in 6 countries (Czech Republic, Hungary, Portugal, Serbia, Spain and Turkey) participating at the 1st phase of the EU COST Action IS1402 initiative and which criterion or what group of regional criteria (European, American, Asian) would be the most specific and most suitable in individual countries for prospective international study following the quality of PIM prescribing. Methods: Of 22 explicit criteria of drugs/drug procedures potentially inappropriate in the old age, validated and published in peer-review journals and journals with the impact factor by 2015 year, a list of all until now known 345 PIMs was created (disregarding the dosage scheme, interval of use or...
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The analysis of extemporaneously compounded prescriptions in the pharmacy of the Hospital České Budějovice
Předota, Václav ; Kostřiba, Jan (advisor) ; Kotlářová, Jana (referee)
The analysis of extemporaneously compounded prescriptions in the pharmacy of the Hospital České Budějovice Author: Václav Předota Hospital České Budějovice Tutor: Jan Kostřiba Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction: However the preparation of extemporaneously compounded medicines is no longer the main activity in the pharmacy, it is still an inseparable part of thepharmaceutical proffesion. The preparation is constantly evolving, therefore it is essential to monitor its status to predict its future evolvement. Objectives: The objective of the thesis was to review a status of prescription of extemporaneously compounded medicines from different points of view. Primarily to verify an assumption, that number of these prescriptions is decreasing, to define specializations of prescribing physicians, to define different dosage forms and their proportion of prescribtions and to define the influence of stoppage of drugs manufactured in factories on the preparation of extemporaneously compounded medicines. Methods: The evaluated file was formed by prescriptions gathered in the pharmacy of the Hospital České Budějovice between years 2015 and 2016. The prescriptions were separated to several groups according to the origin of the...
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Increased living costs of tetraplegic with disability caused by an accident and their compensation by state contributions
Tučková, Vendula ; Kostřiba, Jan (advisor) ; Kotlářová, Jana (referee)
The theme of thesis is to define the living costs of person with the spinal cord injury in the cervical spine - tetraplegics. Tetraplegics are specific group of people with injury. Partial goal is to find out, whether state contributes and compensates health handicap of citizens enough. Thesis describes spends needed on one side and possibilities of state contributions on the other side. First part of theoretical part clarifies handicap of spinal cord injury and associated complications. It describes necessary compensational and medical equipment including process of its aquirement. Second part of theoretical part is based on Czech legislation and analyzes savings, advantages and contributions provided by social system of Czech Republic for disabled people. Practical part evaluates survey as a background for final conclusion of economic situation of tetraplegics. Key words tetraplegia, healthcare system, Czech Republic
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Analysis of the Dispensing Care Provided by Pharmacies in Hradec Kralove
Ličková, Aneta ; Kostřiba, Jan (advisor) ; Pokladníková, Jitka (referee)
Analysis of the Dispensing Care Provided by Pharmacies in Hradec Kralove Author: Aneta Ličková Supervisor: PharmDr. Jan Kostřiba, Ph.D. Charles University, Faculty of Pharmacy, Hradec Kralove Department of Social and Clinical Pharmacy Introduction: Nowadays, a high professional level of dispensing activities is an indispensable prerequisite for the proper work of a pharmacist. A pharmacist is also very often the last link in the chain of healthcare professionals involved in the treatment of a patient and thus has a unique opportunity to detect any potential errors or risk of a given therapy. Regarding the self- medication, the pharmacist is often the only person, with whom the patient consults his therapy. Objective: The aim of this thesis is to analyse dispensing activities provided by pharmacies in Hradec Kralove. Methodology: Analysis of a dispensing activity of a prescription-only drug and over-the- counter product. The list of pharmacies was identified through the SÚKL database. The data collected during the visits were from the 32 pharmacies in total. The data collection tool was mystery shopping that followed thoroughly prepared scenario. The customer was a 26-year-old woman in the 10th week of pregnancy who had come up to pharmacies with a prescription for tetracycline antibiotics and she...
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