National Repository of Grey Literature 46 records found  1 - 10nextend  jump to record: Search took 0.00 seconds. 
Health care providers of complementary medicine
Sopková, Ema ; Pokladníková, Jitka (advisor) ; Kostřiba, Jan (referee)
HEALTH CARE PROVIDERS OF COMPLEMENTARY MEDICINE Charles University, Faculty of Pharmacy in Hradec Králové Department of Social and Clinical Pharmacy Student: Ema Sopková Tutor: PharmDr. Jitka Pokladníková, PhD. Introduction: The interest and use of complementary and alternative medicine (CAM) is constantly expanding. Despite the increased prevalence of the use of CAM in the Czech Republic, no common approach to regulation or general legislation of KAM has been adopted so far. At present, there is a lack of view of this issue on the part of KAM therapists in the Czech Republic. Aim: To determine the attitudes of CAM therapists to the regulation of CAM according to the criteria of evaluation of regulation, which are based on the requirements for health professionals. The secondary objective was to determine the influence of socio-demographic characteristics on the attitudes of CAM therapists. Methods: The cross-sectional prospective observational study was carried out using an online anonymous questionnaire survey in the period from March 29, 2021 to April 18, 2021. The questionnaire was sent to registered associations of complementary medicine therapists in the Czech Republic, selected in the public register of subjects. Data were collected over a three-week period, during which respondents were...
Tricyclic Antidepressant Consumption in Czech Republic
Květenská, Zuzana ; Horký, Pavel (advisor) ; Kostřiba, Jan (referee)
Ticyclic Antidepressants Consumption In Czech Republic Charles University Faculty of Pharmacy in Hradec Králové Department of Social and Clinical Pharmacy Author: Zuzana Květenská Supervisor: PharmDr. Pavel Horký, Ph.D. Tricyclic antidepressants are one of the oldest groups of antidepressants. Except for indication for depression, they are used in the therapy of chronic pain or enuresis nocturna in children. Nowadays, tricyclic antidepressants are drug of the first choice only in some types of neuropathic pain, and in other indications they have been replaced by newer substances with a lower occurrence of side effects. The aim of this works is to find out how consumption of tricyclic antidepressants has developed and what share in utilization of antidepressants they represent. Data for this work were obtained from the State Institute for Drug Control of the Czech Republic; namely from distributors' report about supplies of medicinal products to pharmacies and healthcare facilities, sellers of selected medicinal products, other distributors and veterinary doctors. Utilization was evaluated for the period from 1 January 2008 to 31 December 2018 with DUR (drug utilization review). For evaluation, a defined daily dose per 1000 inhabitants per day and methods of descriptive statistics was selected. A...
The rational use of proton pump inhibitors among geriatric patients in the Czech Republic
Geletová, Ivana ; Fialová, Daniela (advisor) ; Kostřiba, Jan (referee)
Institution/department: Charles University, Faculty of Pharmacy in Hradec Kralove, Department of Social and Clinical Pharmacy Title of diploma thesis: The rational use of proton pump inhibitors among geriatric patients in the Czech Republic Supervisor: Assoc. Prof. Daniela Fialova, PharmDr. Ph.D. Author: Ivana Geletova Introduction: The dynamic process of ageing requires adequate attention at a global level, mainly in the area of providing a proper healthcare. Ageing process is specific by significant involutional changes and is often complicated by higher polymorbidity and polypharmacotherapy. Therefore, it is necessary to eliminate the negative impact of possible drug-related and nondrug-related risk factors and to ensure the rational use of medicines. Proton pump inhibitors (PPIs) are one of the most frequently prescribed classes of drugs in older adults, administered especially for the treatment of gastrointestinal tract (GIT) disorders associated with increased secretion of gastric acid and/or impairment of GIT or as a preventive treatment of potential drug-related and other gastropathies. This diploma thesis focused on evaluating the prevalence of use of PPIs among geriatric patients in acute, ambulatory and pharmacy settings of healthcare in the Czech Republic, in the EUROAGEISM H2020...
Ageing of the population and use of low-dose drug regimens in older patients (II.)
Koleníková, Jana ; Fialová, Daniela (advisor) ; Kostřiba, Jan (referee)
Title: Ageing of the population and use of low-dose drug regimens in older patients (ii.) Author: Jana Koleníková Tutor: Assoc. Prof. Daniela Fialová, PharmD, Ph.D. University: Charles University Faculty: Faculty of Pharmacy in Hradec Králové Department: Department of Social and Clinical Pharmacy Introduction: Proportion of seniors in the population is increasing worldwide, therefore rational pharmacotherapy in older adults is more emphasized. The drug pharmacokinetics and pharmacodynamics change in older age due to physiological and pathological changes, but also due to frequent polymorbidity and polypharmacotherapy. The use of certain medicines is therefore considered risky in seniors. For this reason, explicit expert criteria of medications potentially inappropriate in the aged (so called PIMs) have been created in many countries. Considering the fact that seniors were usually not included in randomized controlled trials, information about specific dosing in older adults for many medications is not stated in Summary of Product Characteristics (SmPCs) which provide basic information on effective and safe administration of medicines. The aim of the diploma thesis was to clarify whether in case of PIMs specific information about geriatric dosing is stated in SmPCs, or at least general warnings that...
Risks and problems associated with polypharmacy in older patients - A self-screening tool for identifying risks of pharmacotherapy by patients themselves
Pitrová, Markéta ; Fialová, Daniela (advisor) ; Kostřiba, Jan (referee)
Title: Risks and Problems Associated with Polypharmacy in Older Patients - A Self-Screening Tool for Identifying Risks of Pharmacotherapy by Patients Themselves Author: Markéta Pitrová Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové Supervisor: Assoc. Prof. Daniela Fialová, PharmD, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové and Department of Geriatrics and Gerontology, 1st Faculty of Medicine and General Teaching Hospital, Prague, Czech Republic BACKGROUND With the increasing number of older adults in the population nowadays, the importance of rational pharmacotherapy - the indication of the most effective, most safe and most cost-effective drug treatments - in older people grows. In order to early assess and resolve the risks of pharmacotherapy in this population, different pharmacotherapy risk assessment and risk management tools have been developed for use by physicians, pharmacists and other health care professionals. As the active involvement of older adults in the process of pharmacotherapy risk assessment and risk management increases, it is crucial to create also patient self- assessment tools in this area. Thus, the aim of the diploma thesis was to develop and test in a pilot study a new patient...
Cardiovascular risc factors and complications associated with atherosclerosis - their prevalence and control in seniors in the EUROAGEISM H2020 project
Kubíková, Veronika ; Fialová, Daniela (advisor) ; Kostřiba, Jan (referee)
INTRODUCTION Cardiovascular diseases (CVD) are currently on the first place among the causes of death worldwide and also in the Czech Republic (CR). The most common causes of death among CVDs are disorders associated with atherosclerosis (ATS) and the prevalence of atherosclerosis and their complications increases with increasing age. The aim of this diploma thesis was to document CVS morbidity in geriatric patients in the sample of FIP7 program of the EUROAGEISM H2020 project, mainly the prevalence of CVS disorders associated with ATS, and to evaluate the controll of risk factors associatedwith general risks of progression of ATS. METHODS The data collection for this theses was carried out in the CR from September 2018 to January 2019 in patients in acute care at the age of 65 and older at geriatric wards in Hradec Králové (HK) and Brno. Patients involved in the study were those admitted to hospitalization at the time of data collection, were complying with inclusion criteria and undersigned the informed consent. The Ethics committee of the Faculy of Pharmacy, Charles University and ethics committee of participating healthcare facilities approved the project. Information have been obtained using the questionnaire for comprehensive geriatric assessment which is the secured instrument of the...
Parameters of Drug Assessment in the Therapy of Rare Diseases
Ornstová, Eva ; Kostřiba, Jan (advisor) ; Klimeš, Jiří (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Social and Clinical Pharmacy Candidate Mgr. Eva Ornstová Consultant PharmDr. Jan Kostřiba, Ph.D Title of Thesis PARAMETERS OF DRUG ASSESSMENT IN THE THERAPY OF RARE DISEASES KEY WORDS: rare diseases, health technology assessment, health policy, drug policy OBJECTIVES The aim of this study was to find out how can the use of multiple criteria in Health technology assessment (HTA) influence outcome in different drug categories. Especially in relationship to orphan medicinal products. Next objective was to explore, which criteria are the most important in the value of the drug and to measure the difference in the preferences among three stakeholder groups in the Czech Republic. METHODS The set of 10 criteria was selected by the expert panel and 3 model treatments were described. Two-round questionnaire was developed and distributed among highly qualified representatives of three stakeholder groups (patients or carers, clinicians and policy makers). In the first round participants provided weights for each criterion by answering on the scale from 1 to 7. In second round participants scored model treatments according to their performance in each criterion. Normalized weights were combined with scores and treatments were...
Medicines shortages in the Czech Republic
Přecechtělová, Martina ; Kostřiba, Jan (advisor) ; Zimčíková, Eva (referee)
7 Abstract Charles University, Faculty of Pharmacy in Hradec Králové Department of Social and Clinical Pharmacy Author Mgr. Martina Přecechtělová Supervisor PharmDr. Jan Kostřiba, Ph.D. Title of rigorosum thesis Medicines shortages in the Czech Republic Introduction: Medicines shortages are a phenomenon, which is not affect just the Czech Republic but it has become a complex global problem across all continents. There is no one factor that can be comprehensively confused about this issue, but several factors, that more or less influence each other. In my work, I will address several factors from the problems of manufacture active substances, registrations problems and distribution for Czech market to redistributions of medicines, which is discussed topic in these days. I will try to compare numbers of essentials medicines as defined in the World Health Organisation (WHO) and their real presence/deficit in the Czech market. Objectives: The aim of the theoretical part of this rigorous thesis was to analyze the issue of unavailability of medicinal products and to summarize the most significant problems related to this topic. The aim of the practical part was to analyze the availability of individual groups of medicinal products in the Czech Republic. Methods: The data used were obtained by analyzing the...
The Analysis of Senior's Opinions on Self-treatment by non-steroidal anti-inflamatory drugs III
Procházka, Marek ; Doseděl, Martin (advisor) ; Kostřiba, Jan (referee)
The Analysis of Seniors' Opinions on Self-treatment by Non-steroidal Anti-inflamatory Drugs III Charles University, Faculty of Pharmacy in Hradec Králové Department of: Social and Clinical Pharmacy Candidate: Marek Procházka Consultant: PharmDr.Martin Doseděl, Ph.D. Background: Self-treatment is one of the approaches in managing pain which is still gaining higher level of importance even amongst seniors. One of the most favourite over the counter (OTC) analgesics is ibuprofen, however its use can be associated with certain drug related problems (DRP). The potential of DRPs is increasing with age which makes seniors more sensitive to them. Aim of study: 1) To create an overview of DRPs of OTC analgesics, focusing on paracetamol (acetaminophen). 2) Through the survey find out the knowledge and experience of seniors with self-treatment by OTC analgesics. The other aim was to evaluate their sources of information concerning ibuprofen and their preferences to each product. Methods: The observable cross-sectional study was made through social media and in Královéhradecký region. In the first case the questionnaire was spread through social media- Facebook. In the second case standardised conversation with questionnaire lists was applied with seniors above 60 years of age. The research was anonymous and...
Ageing of the population and specific aspects of prescribing of hypnotics in older adults (II.)
Puldová, Karolína ; Fialová, Daniela (advisor) ; Kostřiba, Jan (referee)
Title: Ageing of the population and specific aspects of prescribing of hypnotics in older adults (II.) Student: Karolína Puldová, Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Czech Republic Supervisor: Assoc. Prof. Daniela Fialová, PharmD, Ph.D., Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové and Department of Geriatrics and Gerontology, 1st Faculty of Medicine and General Teaching Hospital, Prague, Czech Republic Introduction: World population is ageing and rational geriatric pharmacotherapy receives increasing attention. In seniors, rational pharmacotherapy is complicated by many risk factors, especially by physiological and pathological changes accompanying ageing, polymorbidity, polypharmacy, higher risk of adverse drug events, drug interactions and other risk factors. Particularly psychotropics belong to drug classes where rational prescribing in seniors often requires respecting of different rules. This diploma thesis focuses on specific aspects of irrational prescribing of hypnosedatives in ambulatory geriatric patients, particularly in the area of use of nongeriatric doses and nongeriatric lenght of therapy. Methodology: Data collection for this diploma thesis has been conducted between 2019-2020 years in the...

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