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Hotel with sports background
Karásek, Petr ; Konečná, Klára (referee) ; Müller, Jan (advisor)
The main subject of the diploma thesis is a new construction of the hotel with sporting facility in Kuřim. The Thesis is done in a form of a project documentation with all requests by the law and regulations included. The project is Composed of two buildings, a hotel and the sporting hall. The building is Located in slope in direction to south direction. The hotel building have four Storeys. The whole disposition solution of both buildings is connected. In a first floor is located the hotel restaurant, staff background, wellness and fitness Secon and third floor is supposed to be Used Mainly for accomodating of Sportsmans, and the last fourth floor is for holding meetings and conferences. The main Supporting structure is done with as monolitic frame construction of beams, columns and continuous slabs. All roofs are done as mono-layer roofs. First floor of the sporting hall is used by people during the sporting activity. This area is composed of changing rooms with a social background and other spaces for the proper function of the hall. The main Supporting construction of the hall is designed as glued lamellar beams supported by columns.
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Accessibility of Web Technologies and Standards
Konečná, Kateřina ; Trchalík, Roman (referee) ; Očenášek, Pavel (advisor)
This thesis deals with accessibility and web standards. It explains the importance of creating accessible web pages due to disabled users. Individual disabilities are briefly described in a separate chapter. The thesis presents a summary of Web accessibility standards in Europe, America, Australia and Asia. This analysis is completed by comparing the individual countries. The second part focuses on the formalization of different ways, where three methods are applied to three different guidelines.
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The Operating Point of the Centrifugal Pump.
Konečná, Kateřina ; Haluza, Miloslav (referee) ; Štigler, Jaroslav (advisor)
Target of diploma thesis The Operating Point of the Centrifugal Pump was create program for analyze system of pumps, it would be an effective instrument at projection these systems. Program is divided into two parts: system characteristic and performance characteristic. Subject of this thesis is create pumps database, enter performance characteristics and succeeding working with them. Program enable regulation pump with change speed and cooperation two pumps, work in parallel or series. The result of program is project system of pumps on enter parameters with more economy work.
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Evaluation of the efficiency of root treatment plants via ecotoxicity tests
Konečná, Kateřina ; Procházková, Petra (referee) ; Zlámalová Gargošová, Helena (advisor)
This bachelor thesis focuses on the evaluation of the efficiency of root treatment plants using appropriately selected ecotoxicity tests. For these purposes, ecotoxicological tests in an aquatic arrangement were used, specifically with the planktonic organism Thamnocephalus platyurus and the plant Lemna minor. The evaluation was performed at a municipal root treatment plant, which treats water for 955 equivalent inhabitants. The results of tests with T. platyurus confirmed that the root treatment plant sufficiently relieves acute toxicity of water. LC50 values were determined for two samples, 213.71 ml / l for the inflow and 388.20 ml / l for the settling tank. At the outflow, these values could no longer be determined due to the low ecotoxicological effect of the water thus treated. For tests with L. minor, IC50 values were also calculated for the first two samples. For Sample No. 1, the IC50 value was calculated to be 311.25 ml / l, for Sample No. 2 to 963.35 ml / l. However, on the basis of tests of direct toxicity of waters with L. minor, it is possible to confirm even in the case of this organism, a good cleansing effect of this root treatment plant.
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Study of the development of microbial biofilm within an experimental model, Galleria mellonella
Doubová, Dominika ; Konečná, Klára (advisor) ; Janďourek, Ondřej (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Candidate: Dominika Doubová Supervisor: RNDr. Klára Konečná, Ph.D. Title: Study of the development of microbial biofilm within an experimental model, Galleria mellonella Aim of the thesis: The aim of this thesis is to introduce the invertebrate organism, Galleria mellonella (G. mellonella), that can be used within the scientific research as an alternative model organism to vertebrates. This model seems to be more financially favorable and more ethically acceptable, which is an essential fact in the current era of increasing pressure to abandon testing on vertebrates in particular. The experimental part of this thesis is focused on optimizing the utilization of the G. mellonella larvae as a model organism within the research of fungal burn wounds fungal infections induced by the yeast Candida albicans. Within these experiments, larvae were used to preparation of tissue explants on which the formation of a single- species yeast biofilm was investigated. Methods: Before obtaining of tissue explants, the larvae were decapitated. To reduce contamination of tissue samples primarily by the gut microbiota of the larvae, the approach of removing the digestive tube was optimized. Burn wounds were induced...
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Study of in vivo toxicity of selected compounds with the implementation of the invertebrate model Galleria mellonella
Turinová, Veronika ; Konečná, Klára (advisor) ; Janďourek, Ondřej (referee)
6 ABSTRACT Charles university, Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Study program: Pharmacy Author: Veronika Záveská Supervisor: RNDr. Klára Konečná, Ph.D. Title of thesis: Study of in vivo toxicity of selected compounds with the implementation of the invertebrate model Galleria mellonella Background: The aim of this diploma thesis was to monitor the influence of the weight of the larvae, or rather its developmental stage, on the results after the administration of selected doses of DMSO. In the experimental work, the toxic impact of DMSO on larvae was evaluated not only from the point of view of mortality. Much attention was also paid to the characteristic features that are commonly observed during tests on Galleria mellonella larvae, such as the degree of melanization, the impact on activity and cocoon formation. Methods: For individual experiments, three test groups of six individuals each were created based on weight, one group of larvae weighing 250 ± 10 mg, the second group weighing 350 ± 15 mg and the third group weighing 450 ± 15 mg. Using a Hamilton syringe, a volume of 10 µl of the test solution with the appropriate concentration of DMSO was administered to each larva directly into the haemocoel through the last left proleg. The administered doses...
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Implementace koncepce Smart City v oblasti sociálních a zdravotních služeb ve Zlínském kraji
Konečná, Kamila
The main aim of given master thesis is to analyse the current situation of the implementation of the Smart City/Region concept in field of social services and health care services in Zlín region. The theoretical part of this thesis pays attention to the key theoretical concepts, which are essential for the understanding of the whole topic. The following analytical part of this thesis firstly analyses the role of the region in the process of implementation of the Smart City/Region concept. Secondly it aims to analyse the current situation of the implementation of the Smart City/Region concept in given field of social services and health care services within the Zlín region. At the end, the attention is given to the exploration, whether the Covid-19 pandemic could potentially influence the development of implementation of the Smart solutions within the given field. The analytical part of the thesis is based on the secondary information from the relevant methodical and strategic documents at the national and regional level. The significant sources of data are also primary information from the group interview with the 3 relevant representatives of the regional office of Zlín region and semi structured interviews with 2 relevant representatives of the social service organizations and 2 relevant representatives of the health care service organizations. Finally, the master thesis seeks to evaluate actual situation and practices of the implementation of the Smart City/Region concept in given agenda of social services and health care services. It seeks to identify the existing problems and barriers and tries to suggest the possible recommendations for further development of the implementation of the Smart solutions within the particular field of social services and health care services in Zlín region.
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Sociální zemědělství v praxi
Konečná, Klára
This bachelor thesis deals with the issue of social farming in the Czech Republic and in Europe, and the approximation of the functioning of social farming in practice on a selected subject. The bachelor thesis has a theoretical and practical part. In the theoretical part, a literature research on the topic was developed and in the practical part, the functioning of the social farm Květná Zahrada z.ú., was described and evaluated in detail using the method of field survey, semi-structured interview and SWOT analysis. The SWOT analysis identified a predominance of strengths that the farm can use to fulfil the opportunities and the outputs of the SWOT analysis, semi-standardised interview and field survey confirmed the effective functioning of social farm Květná Zahrada in the concept of social farming in the Czech Republic.
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Study of the development of microbial biofilm within an experimental model, Galleria mellonella
Doubová, Dominika ; Konečná, Klára (advisor) ; Janďourek, Ondřej (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Candidate: Dominika Doubová Supervisor: RNDr. Klára Konečná, Ph.D. Title: Study of the development of microbial biofilm within an experimental model, Galleria mellonella Aim of the thesis: The aim of this thesis is to introduce the invertebrate organism, Galleria mellonella (G. mellonella), that can be used within the scientific research as an alternative model organism to vertebrates. This model seems to be more financially favorable and more ethically acceptable, which is an essential fact in the current era of increasing pressure to abandon testing on vertebrates in particular. The experimental part of this thesis is focused on optimizing the utilization of the G. mellonella larvae as a model organism within the research of fungal burn wounds fungal infections induced by the yeast Candida albicans. Within these experiments, larvae were used to preparation of tissue explants on which the formation of a single- species yeast biofilm was investigated. Methods: Before obtaining of tissue explants, the larvae were decapitated. To reduce contamination of tissue samples primarily by the gut microbiota of the larvae, the approach of removing the digestive tube was optimized. Burn wounds were induced...
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Current possibillities of laboratory diagnostics of EBV
Janů, Denisa ; Janďourek, Ondřej (advisor) ; Konečná, Klára (referee)
Charles university Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Study programme: Bioanalytical laboratory diagnostics in health care Author: Bc. Denisa Janů Supervisor: PharmDr. Ondřej Janďourek, Ph.D. Title of diploma thesis: Current possibillities of laboratory diagnostics of EBV Background: The aim of this diploma thesis was to get acquainted with the issue of Epstein-Barr virus infection and its laboratory diagnostics. Other aim was to divide the patients into groups according to the serological results, then evaluate the prevalence of EBV and evaluate the incidence of primary EBV infection in the tested group of patients for the years 2019-2022. Methods: Chemiluminescence immunoassay and indirect immunofluorescence were used to determine specific antibodies against EBV. In some cases, the examination was completed by determining the avidity of anti-VCA IgG antibodies and the microblot array method. Real-time PCR was used to detect EBV DNA. Microsoft Excel 2016 was used to process data and to create tables and graphs. Results: For the years 2019-2022, 14,736 patients were tested for the presence of specific antibodies against EBV in the infectious serology and virology laboratory of Vidia-Diagnostika, 263 patients for the presence of heterophile antibodies...
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