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Studium of the clinical impact of different forms of cardiac resynchronisation therapy by patients with chronic heart failure
Burianová, Lucie ; Kautzner, Josef (advisor) ; Janoušek, Jan (referee) ; Táborský, Miloš (referee)
Studium of the clinical impact of different forms of cardiac resynchronization therapy by patients with chronic heart failure MUDr. Lucie Burianová ABSTRACT: Introduction: Biventricular (BiV) pacing decreases mortality and improves quality of life of patients with severe heart failure. Haemodynamic and short time clinical studies suggest that isolated leftventricular pacing could have the same effect. Aims: Compare the effect of BiV and leftventricular pacing by subjects with dilated cardiomyopathy and severe heart failure with the attention to signs of dyssynchrony and remodelation of the left chamber. In methodical substudy compare the results of left chamber volumes and ejection fraction (EF LK) measured by CT angiography and 2-dimensional echocardiography with use of contrast agent (K-ECHO). Methods: Patients indicated for cardiac resynchronization therapy were randomized for either BiV or leftventricular pacing. After implantation of the device they were examinated clinically and by echocardiography every 3 months in the period of one year. Four years from the onset of the study the major adverse events in both groups were evaluated. The results of left chamber volumes and EF LK measured by K-ECHO and CT angiography were compared. Results: We enrolled 33 patients. We found clinical improvement in both...
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The impact of positive inotropic and antiarrhythmic drugs on cardiovascular system
Kočková, Radka ; Linhart, Aleš (advisor) ; Janoušek, Jan (referee) ; Štengl, Milan (referee)
Heart rate changes mediate the embryotoxic effect of antiarrhythmic drugs in the chick embryo A significant increase in cardiovascular medication use during pregnancy has occurred in recent years but only limited evidence on its safety profile is available. We hypothesized that drug-induced bradycardia is the leading mechanism of developmental toxicity. We tested metoprolol, carvedilol, or ivabradine for embryotoxicity and their acute effect on chick embryonic model. We used video microscopy and ultrasound biomicroscopy. Significant dose-dependent mortality was achieved in embryos injected with carvedilol and ivabradine. In ED4 embryos, metoprolol, carvedilol and ivabradine reduced the heart rate by 33%, 27%, and 55%, respectively, compared to controls (6%). In ED8 embryos this effect was more pronounced with a heart rate reduction by 71%, 54%, 53%, respectively (controls 36%). Cardiac output decreased in all tested groups but only proved significant in the metoprolol group in ED8 embryos. The number of -adrenergic receptors showed a downward tendency during embryonic development but a negative chronotropic effect of tested drugs was increasingly pronounced with embryonic maturity. This effect was associated with reduced cardiac output in chick embryos, probably leading to premature death....
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Study of the highspeed line Hradec Králové - state border CZ/PL
Talapka, Filip ; Janoušek, Jan (referee) ; Plášek, Otto (advisor)
The aim of this master's degree thesis is a design the route of the high-speed railway line between Hradec Králové - state border CZ/PL. The section starts near the town of Jaroměř and ends at the state border of CZ / PL, near the village of Petříkovice. The proposal is developed in two basic variants, variant nr. 1 only for passenger traffic and variant nr. 2 for mixed traffic of passenger and freight transport. Part of both variants is the design of the exit to the conventional network near the town of Trutnov, enabling its connection to the high speed railway in the direction of Hradec Králové - Trutnov. Part of the work is also the calculation of investment costs for the implementation of individual variants.
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Railway Station Podebrady HSR
Piruš, Erik ; Janoušek, Jan (referee) ; Dušek, Erik (advisor)
The master´s thesis deals with the design of the transfer terminal on the proposed high speed railway Prague - Hradec Kralove - Wroclaw near the town of Podebrady and exit 39 from the D11 motorway. The work includes the design of station layout, platforms, access roads, bus stops and parking house. As part of the railway station design naintenance base with the loading area. The integral parts of the thesis is design of the railway superstructure, substructure and drainage system.
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Design of junction point Jistebník
Talapka, Filip ; Janoušek, Jan (referee) ; Plášek, Otto (advisor)
The aim of this bachelor thesis is to design a rail connection between the corridor track Přerov – Ostrava and a high-speed track Přerov – Ostrava near the village Jistebník. The flyover interconnections are designed in all four directions for a maximum speed of 160 km / h. The proposal is divided into two basic variants – the minimization of land occupation and the minimization of engineering objects.
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Bělotín Junction and Passing Point Study
Piruš, Erik ; Janoušek, Jan (referee) ; Dušek, Erik (advisor)
The bachelor's thesis is focused on design of the separated level connection of the High speed line Prerov - Ostrava to the conventional line Prerov - Ostrava near Hranice na Morave station (connected from the Ostrava side). The thesis should include the track geometry design of the conventional line and design of the Belotin Junction, consisting of two overtaking tracks, each one for one of the directions.
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The Presentation of Transforming Attributes in SQL for Data Governance Support
Bartoš, Michal ; Janoušek, Jan (advisor) ; Kopecký, Michal (referee)
This thesis examines extraction of attributes' transformation descriptions from Oracle SQL scripts and possibilities of their presentation to users. This thesis com- pares several variants of output format. Then it describes details of construction for the chosen format and choices that led to it. One of the main decisions was the choice of input data structures: abstract syntax tree and dataflow graph. Those data structures provide initial analysis of input SQL scripts but they also strongly influence the rest of processing. Results of this thesis were verified by prototype implementation in software Manta. The prototype confirmed suitability of the chosen approach for convenient presentation to users. 1
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Registration of claims in insolvency proceedings
Janoušek, Jan ; Smolík, Petr (advisor) ; Winterová, Alena (referee)
RAISING CLAIMS IN INSOLVENCY PROCEEDING - ENGLISH ABSTRACT The aim of this thesis is to provide a comprehensive summary of institutes of an insolvency law related to the application of claims as well as defining the rights and obligations of creditors related to this topic with a closer focus on risk and problematic facts appearing in practice. All the text is based on the insolvency law effective at the time of its creation and besides the academic literature also often uses related practice of the courts. The introductory part presents an insolvency law in its historical and also contemporary context. It is listing the material sources and their brief characteristics needed to simplify the understanding of the substance of an insolvency law. For the same reason the initial chapters deal with the basic principles and terminology of an insolvency law, namely an insolvency proceeding, a bankruptcy and closely characterize particular ways of solving a debtor's bankruptcy. Another part of this thesis focuses on the actual debts. The legal analysis of the term debt and its types that are applied during insolvency proceedings is being carried out and it involves also the list of debts excluded. On the other hand this part includes the theory of debts with no need to be applied, since those are registered into...
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