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Porosity during welding aluminous alloys
Hájková, Alena ; Daněk, Ladislav (referee) ; Sigmund, Marian (advisor)
This thesis deals with the problem of occurrence of porosity in aluminous alloys and the methods of their repair in the company IFE. Theoretical part is aimed on the current state of porosity and the ways in which the be pores can be repaired. Used technologies of repairs are TIG welding and cementing. The practical part consists of experiment in which is used a method of cementing on specific part.
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Characterization of molecular components in cannabinoid signaling pathways.
Hájková, Alena ; Blahoš, Jaroslav (advisor) ; Vyklický, Ladislav (referee) ; Maletínská, Lenka (referee)
The cannabinoid receptor 1 (CB1R), a member of the G-protein coupled receptors superfamily, is a key player in endocannabinoid signalling. The CB1R is found presynaptically in neurones where it modulates synaptic plasticity. Precise description of the molecular mechanisms of synaptic neurotransmission is crucial for understanding of brain diseases and development of new therapeutic aproaches. Possible pharmacological targets of CB1R signalling include the treatment of various ailments such as energy imbalance disorders (anorexia, obesity), drug addiction, pain, insomnia, and some psychiatric conditions. This study reveals the "Src homology 3-domain growth factor receptor-bound 2-like (endophilin) interacting protein 1" (SGIP1) as a novel interacting partner of the CB1R. The SGIP1 is an intracellular neuronal protein localized predominantly in axon terminals and is involved in clathrin mediated endocytosis. The overexpression of SGIP1 imbalance energy homeostasis and leads to obesity. We show that SGIP1 affects CB1R signalling via ERK1/2 whereas G-protein signallization remains unaltered. The SGIP1 also hinders CB1R internalization from the cell surface and supports its interaction with β-arrestin2. Also, we demonstrated heterodimerization of the main splice variants of metabotropic glutamate...
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The significance of risks to the empowerment of individuals with mental disabilities and the possibility of taking in DZR Terezin
Hájková, Alena ; Vařeková, Jitka (advisor) ; Hošková, Blanka (referee)
Title: The importance of risk for the empowerment of individuals with mental disabilities and the possibility of taking in DZR Terezin Objectives: The aim of this paper is to examine the phenomenon of risk-taking and its importance in the process of empowerment of persons with mental disabilities in social services. Methods: In empirical research we were surveyed employee attitudes DZR Terezin to the issue of risk in social services. In the first part of the research was to look at the views and attitudes of social workers employed form questionnaire (Lepešková, 2013) in a group of 22 employees - women with a mean age of 46 years. The second part of the research were semi-structured interviews with staff enabling deeper qualitative analysis of the problem. Talks with 7 employees participated. 6 women and 1 man. The recording was used edited form an interview. Results: The survey both methods show that the respondents as one of the most important tasks when working with the risks and support to people deemed to support their independence. The aim is to get clients to the extent possible, make their own decisions about their own lives. An essential element in this process is considered self- management. The client does not passively wait to social service workers determine what to do and what will...
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