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Intra-amniotic Inflammation in Women with Preterm Labor with Intact Membranes - Clinical and Experimental Aspects
Stráník, Jaroslav ; Kacerovská Musilová, Ivana (advisor) ; Šimetka, Ondřej (referee) ; Čečková, Martina (referee)
Preterm labor with intact membranes (PTL) is responsible for approximately 40% of all preterm deliveries. PTL is frequently complicated by intra-amniotic inflammation (IAI), characterized by the elevation of inflammatory mediators in the amniotic fluid. Based on the presence or absence of microbial invasion of the amniotic cavity (MIAC), two different clinical phenotypes of IAI are distinguished: i) intra-amniotic infection, when microorganisms are present in the amniotic fluid, and ii) sterile IAI, when there are no microorganisms in the amniotic fluid. The clinical severity of both phenotypes of IAI is underlined by their association with adverse neonatal outcomes. In addition to the presence or absence of MIAC, there are also differences between the phenotypes of IAI in terms of their intra-amniotic inflammatory status characteristics. The clinical part of this thesis has addressed these differences in women with PTL. The first specific aim of this clinical study was to determine the concentration of interleukin (IL)-6 in the cervical fluid of women with PTL complicated by intra-amniotic infection and sterile IAI. The second specific aim was to determine the concentration of IgGFc-binding protein (FcgammaBP) in the amniotic and cervical fluids of women with PTL complicated by intra-amniotic...
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Effect of hysterotomy suture techniques after cesarean on its healing
Hanáček, Jiří ; Krofta, Ladislav (advisor) ; Ľubušký, Marek (referee) ; Kacerovská Musilová, Ivana (referee)
Introduction: This prospective randomised study compared healing of the scars after cesarean section during the first postpartum year using a single or double layer suturing technique. Material and methods: Women with uncomplicated singleton pregnancies indicated for elective or acute cesarean section were randomly allocated to the uterine closure technique group. During the first postpartum year, their lower uterine segment was examined with a transvaginal ultrasound in 3 consecutive visits at 6 weeks, 6 months, and 12 months. Results: 324 women had the 12 months visit, out of these 149 underwent single layer closure of the uterine incision, 175 underwent double-layer technique. A higher proportion of the defects is seen in the single layer closure technique of suturing. Defects in the single layer group were wider (0.002) and the residual myometrial thickness in the single layer group were thinner (0.019). Women who underwent cesarean section at the stage of full cervical dilation had scars that were closer to the external cervical os (0.000). Conclusions: The findings of this study demonstrate that double layer technique with the first continuous nonlocking suture followed by a second continuous nonlocking suture is associated with better suture healing and greater residual myometrial thickness.
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Changes in nutrition, resting energy expenditure, and body composition of Czech women during pregnancy and lactation in relation to birth parameters and milk production.
Najpaverová, Simona ; Hronek, Miloslav (advisor) ; Tláskal, Petr (referee) ; Kacerovská Musilová, Ivana (referee)
Charles University, Faculty of Pharmacy in Hradec Kralove Department of Biological and Medical Sciences Candidate: Mgr. Simona Najpaverova Supervisor: doc. PharmDr. Miloslav Hronek, Ph.D. Title of Doctoral Thesis: Changes in nutrition, resting energy expenditure, and body composition of Czech women during pregnancy and lactation in relation to birth parameters and milk production Introduction and objective: During pregnancy, a woman's body undergoes many changes that support proper fetus development and prepare the mother's body for delivery as well as subsequent breast-feeding period. Monitoring of these changes, can detect a non-physiological course of pregnancy and thus prevent potential complications that disrupt fetus development, the delivery itself, lactation or newborn future life. This longitudinal study aimed to detect changes in maternal body composition, resting energy expenditure (REE) and nutritional intake during pregnancy and lactation and assess the relationship of these parameters with newborn characteristics (height, weight) and maternal milk production, which is not well known in women of the Czech population. Methods: 92 healthy primiparous Czech women with a physiological pregnancy were included in the study. The examinations of women were performed in three pregnancy periods...
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Physiological and pharmacological aspects of tryptophan and serotonin homeostasis in the fetoplacental unit
Karahoda, Rona ; Štaud, František (advisor) ; Stuchlík, Aleš (referee) ; Kacerovská Musilová, Ivana (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Candidate Mgr. Rona Karahoda Supervisor Prof. PharmDr. Frantisek Staud, Ph.D. Title of Doctoral Thesis Physiological and pharmacological aspects of tryptophan and serotonin homeostasis in the fetoplacental unit The placenta is an ephemeral organ inevitable for the successful course of pregnancy. As the main link between the mother and the fetus, the placenta fulfills numerous roles during gestation, including endocrine, transport, and immunoprotective processes. Proper functioning of the placenta is critical for the normal growth and development of the embryo/fetus. Importantly, the latest research has associated perturbations of maternal conditions (such as pharmacotherapy, malnutrition, diseases, stress, or inflammation) with alterations of the trophoblasts' endocrine, transport, and metabolic functions. Of note is the placental utilization of the essential amino acid tryptophan, suggested as a potential mechanism contributing to fetal programming of adulthood diseases. Tryptophan flux along the serotonin and kynurenine pathways generates metabolites with neuroactive, immunosuppressive, and antioxidant properties. Current literature suggests that fine-tuning of tryptophan metabolite concentrations...
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Selection of gluten-free food from the perspective of diagnosed celiac
Musilová, Iveta ; Frühauf, Pavel (advisor) ; El-Lababidi, Nabil (referee)
This diploma focuses on the selection of gluten-free foods from the perspective of a diagnosed celiac. In the theoretical part is described the history of celiac disease, anatomy and physiology of small intestine, pathogenesis, manifestation and forms of celiac disease, diagnosis, screening and complications from celiac disease. It also describes a treatment of celiac disease which shows inappropriate and appropriate aliments in gluten free diet. One chapter deals with labeling of gluten free foods in the Czech Republic and in Canada. There is also a comparison of the Czech Republic and Canada regarding health care, government and restaurants offering gluten free dishes. The aim of the research is to map the selection of gluten free foods in people with diagnosed celiac disease, the second target is to explore differences in food selection in the Czech Republic and Canada. The third objective is focused on factors influencing the choice of gluten free foods. The research was conducted through a questionnaire survey. The survey was filled in the Czech Republic by 78 celiacs and in Canada by 56 celiacs. In the Czech Republic the survey was online on page named Celiake and Mladí Celiaci on Facebook. The Canadian survey was online on page The Celiac scene on facebook and filled out by costumers in...
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The role of solvents in the preparation of hydrophobic nanofibrous membrane containing fumed silica
Peer, Petra ; Polášková, M. ; Musilová, I. ; Filip, Petr
It is well-known that a type of used fumed silica nanoparticles plays a dominant role in wettability of the corresponding nanofibrous mats. As a result, the desired contact angle can be approximately achieved by a choice of adequate fumed silica nanoparticles. However, less attention has been hitherto paid to an active role of solvents in connection with the tailoring this contact angle. For analysis we used poly(vinyl butyral) representing electrospun-friendly material, various types of fumed silica nanoparticles and two solvents - methanol and ethanol. It is demonstrated that a choice of polymer solvents plays a significant role in contact angle changes. Hence, in combination of the type of fumed silica nanoparticles and the type of solvent it is possible to achieve a finer partition of the required contact angles.
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Analysis of the declared strategy of selected breweries from the point of view of its realization
Musilová, Iveta ; Dvořák, Jiří (advisor) ; Tripes, Stanislav (referee)
Thesis of qualitative character deals with the strategy at the business level. The aim of the thesis was to compare two breweries from the point of view of the declared business strategy, the declared strategies to be ranked among the business strategies according to literary research, and to verify the actual fulfillment of the declared strategies of the selected breweries. The verification took place in terms of price level, method and level of distribution. Two breweries operating in the territory of the Czech Republic, in the Pardubice region, were selected for the survey. It was the Municipal Brewery in Polička, a.s. and the Brewery Rychtář, a.s., Hlinsko v Čechách. It was targeted at the management of breweries. Qualitative methods were used to collect data, including qualitative interviewing with the above-mentioned research sample, texts and documents, and field research supplemented by web pages. Subsequently, obtained data was analyzed, interpreted and evaluated. On the basis of the stated goal, the declared strategy of selected breweries was established. According to the literary research, Porter's generic strategies have been used as a type of strategy used in all the selected literature to incorporate the strategy of breweries. The declared strategy of breweries was tended to a differentiation strategy aimed at a wide range of customers. Subsequently, the real fulfillment of the declared business strategy of each brewery was verified. It was found that the declared strategy was largely in agreement with its fulfillment, for both selected breweries. There were no significant differences for each brewery. The benefit of this work was mainly focused on the management of selected breweries, who did not think about their strategies in this way.
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Changes of immigration policies in the United Kingdom, Canada and Australia from 90s to the present
Musilová, Iveta ; Barša, Pavel (advisor) ; Koubek, Jiří (referee)
The text deals with the issue of changes in immigration and integration policies of the United Kingdom, Canada and Australia during last twenty years. At first, it summarizes the theoretical opinions on immigration, integration, multiculturalism and pluralism and makes that so from the point of view of liberalism and communitarianism. Then it focuses on the development of immigration and integration policies in each country in given time period and especially on their qualitative change. Attention is paid to their key principles, legal basis and real practice. Finally, these three approaches are mutually compared and there are outlined their future perspectives.
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