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Autoimmune and lymphoproliferative diseases: associations and common mechanisms
Dobiášová, Alena ; Daňková, Pavlína (advisor) ; Hušáková, Markéta (referee)
Autoimmune and lymphoproliferative diseases share some etiologic mechanisms. The origin of the diseases is complicated process that involves an accumulation of hereditary and somatic mutations in a hematopoetic cell, which thanks to changed activity overcomes different growth and survival control checkpoints. Such mutations are for example those located in genes coding for transcription factors, apoptotic signaling molecules, costimulatory molecules and secreted exctracellular molecules. All these molecules influence the balance between survival and programmed cell death. Their dysregulated expression enables the cell to overcome defensive mechanisms of the immune system. Therefore, autoimmune and malignant cells are able to survive though, under usual circumstances, they would be selected. The main aim of this work is to shed the light on the influence of the dysregulated expression of the particular molecules on the origin of autoimmune and lymphoproliferative diseases. Key words: autoimmune ilnesess, lymphoproliferative diseases, etiology, AIRE, c-MYC, TP53, FOXP3, Fas, PTEN, Bim, CTLA-4, CD5, CD30, CD40/CD40L, BAFF, α-taxilin, IL- 10.
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Line construction within the life cycle from the perspective of BIM
Vacková, Veronika ; Výskala, Miloslav (referee) ; Aigel, Petr (advisor)
The aim of the work was the usage of the Building Information Modelling system to ensure the complete building-up, including the working part of the line constructions. In the first part of my thesis I was dealing with the costs of the total life of the line construction, the line construction life-cycle, with the difference between the Building Information Modelling model and traditional projecting, with the participators participants of the Building Information Modelling model and which levels in the Building Information Modelling exist. In the practical part I was dealing with two levels of the Building Information Modelling designing, in which I set the total price of the building researched and then I was comparing them. In the final chapter of the thesis working expenses were set which are involved in the expenses of the total life.
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Senior's Boarding House
Huleja, Adam ; Struhala, Karel (referee) ; Košíčková, Ivana (advisor)
This thesis is deals with design of a Senior’s Boarding House in Lomnicka u Tisnova. Building four-storey building with one service basement floor with This thesis deals with a design of a retirement home in Lomnicka u Tisnova. This is a four storey building with one service basement floor and with a flat roof. The structural system is of a transverse wall type. Material of structural elements is a combination of reinforced concrete and masonry. The building is founded on piles. In addition, the design includes a restaurant for warming and serving food prepared in different place, laundry and a small pool. All construction drawings and schedules has been developed as building information model (BIM).
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Impact of the economic crisis on the construction market and the current trends in the construction sector
Nováková, Barbora ; Čajka, Radek (advisor) ; Bolotov, Ilya (referee)
The diploma thesis Impact of the economic crisis on the construction market and the current trends in the construction sector focuses mainly on the development of the Czech construction market in relation to the economic crisis of 2008-2009, while looking for conjunctions with macroeconomic indicators. It also describes the following period of development of the construction sector with an emphasis on current trends. Exemplifying how this is implemented into practice, the diploma thesis includes a description of the activities of a group of companies called EBM Group.
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Construction object and its life cycle from the perspective of BIM
Biolek, Vojtěch ; Pospíšilová,, Barbora (referee) ; Aigel, Petr (advisor)
The diploma thesis analyzes detached house created in BIM software. In the practical part was modeled BIM model, which was attributed the Information. Of the exported data was created budget and calculated total cost of building. The part of this work is calculate life-cycle cost and analysis of the most costies parts. The main result of this work is the demonstrace private investors and public procurement the advantages of BIM attitute to projects, Also calculate the price of building and life cycle costs in the studies BIM model can help investor to show how much they will cost of building without investor didn´t invest too much project funds and thus could reconsider the rejection or modification project.
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Modeling and simulation of investment project risk
Pospíšilová, Barbora ; Heralová,, Renáta Schneiderová - (referee) ; Hromádka, Vít (referee) ; Tomanová, Štěpánka (referee) ; Korytárová, Jana (advisor)
This doctoral thesis deals with modelling and simulation of investment projects and linking risk management with new trends in construction industry. Process of balancing of acceptable risk level and investment costs is really complex and is influenced by several uncertainties. Simulation methods are able to model future scenarios of project development and quantify impact of risk factors. The aim of the doctoral thesis is to find an optimal methodology for risk analysis during decision-making process using simulation methods. The methodology links modeling by simulation method Monte Carlo with CBA, with risk analysis respectively. The aim is to reach more effective process of planning of investment projects. An accurate project plan in preinvestment phase will influence effectiveness of life cycle costs significantly. This is proved also by BIM methodology which works on base of transfer and storage of actual and complete information about investment plan within its whole lifecycle. Expected output of the thesis is effective application of simulation methods in risk prediction for modeling of outputs of investment project. Data from model are useful for decision making process, risk management, controlling and postaudit of investments. Projects can be evaluated by their complex benefits and quality with respect to sustainability.
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GIS ANALYSIS IN BUILDING INFORMATION MODELS
Černý, Martin ; Kubíček,, Petr (referee) ; Vyhnálek,, Rudolf (referee) ; Bartoněk, Dalibor (referee) ; Pospíšil, Lubomil (advisor)
This dissertation thesis are concerned about the Geographic Information Systems (GIS) and spatial analyses inside of the Building Information Models (BIM). BIM and GIS are compared from different points of view like data organization, geometry types and modelling paradigms. Results of this comparisons are applied in the first case study where BIM data in IFC format are converted to the SHP format usable for spatial analyses in GIS. The results of the case study are evaluated and new approach for spatial analyses in BIM models is proposed based on the results. The new proposed approach is based on the semantic relations existing in the BIM models. Thesis are concluded with the future development which is in line with authors actual focus.
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Working out of methodology for creation of building information model
Nováková, Věra ; Černý, Martin (referee) ; Hanzl, Vlastimil (advisor)
This thesis is focused on creation of building information model (BIM) for existing buildings. The main objective of this work is to develop the methodology (workflow) for the creation of BIM model using selected geodetic methods, specifically for the modeling based on the existing documentation of the building, the modeling from the handheld distance meter and the modeling from point cloud acquired by the indoor mapping system. The aim of these workflows is to explore the suitability of these methods, to check the limits of each method and to point out the potential issues. Revit (version 2013 and 2014) was used as an authoring environment for creation of the models. Workflow for modeling based on the documentation of the building shows how to insert drawings into Revit and how to create a model based on these drawings. The workflow was developed based on experience with creation of model of an office building. The workflow for handheld laser distance meter describes how to work with rangefinder equipped with Bluetooth, which allows user to create a model onsite. The third part of this thesis deals with creation of BIM from pointcloud acquired by indoor mobile mapping system. The workflow describes data collection and point clouds processing directly in Revit using the ScanToBIM extension. The results of this work are methodical instructions for the methods described above and the comparison of these methods. Workflows contain recommended procedures and highlight common issues and mistakes. This should enable the readers of this thesis to choose the right method and avoid common mistakes.
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Family Residence
Šmejkal, Daniel ; Žižka, Lukáš (referee) ; Vajkay, František (advisor)
The subject of this thesis is a structural solution of a two-storey single-family detached house located on parcel no. 149 in the cadaster area of Hodkovičky. The house is situated in a moderately sloped terrain in a residential area where most of the surrounding objects are also detached houses and it is primarily designed as a timber structure. Other construction materials such as concrete or sand-lime masonry are also used within the project at those parts of the building where we can benefit from their different structural and physical properties. The project documentation was completely developed using Building Information Modeling method (BIM).
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Umístění dřevostavby v terénu pomocí software ArchiCAD s alternativním využitím software Artlantis na lokalitě v obci Krupka, okres Teplice.
Dvořák, Radomír
This thesis deals with the solution of practical placement of modern wooden building into a terrain using the software Archicad with following application of the program Artlantis Studio for correction and rendering of visual annex of thesis. The first part contains theoretical assumptions for a geodetic measuring, the legislation asociated with placement of building into a terrain and constructional solution. The next part describes the basic functions of the software ArchiCAD and Artlantis Studio. The last part is focused on the practical fitting of building into the terrain including digital 3D models and incision of the field and the wooden building.
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