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The role of T regulatory cells in kidney transplantation
Urbanová, Anna ; Stříž, Ilja (advisor) ; Zajícová, Alena (referee)
T regulatory lymphocytes (Treg) belong to the CD4+ cell group. They are an essential part of the immunity system. Treg cells prevent from excessive activation of effector T cells and they keep the tolerance to the tissues of the body. They have high expression of CD25 and the transcription factor Foxp3. We distinguish two basic populations of Treg cells: natural Treg cells (nTreg) created in the thym and representing 5-10 % of all CD4+ cells, and induced Treg cells (iTreg), created from naive CD4+ cells in the periphery.Their regulatory effect is well-known, therefore using of Treg cells could bring about a huge treatment potential for patients with a transplantated kidney. Healthy people and patients tolerant to the transplantated kidney show higher occurance of circulating Treg cells and the Treg cells present in the graft unlike patients with chronical rejection. The tolerance is cancelled with the damage of CD4+ CD25+ cells.For a graft acceptance it is necessary to treat the patient after the transplantation with immunosuppressive medicaments resulting in suppression of immunity reaction against the graft. Their disadvantages are side effects often resulting in the patient's death. Moreover they often have a negative impact on survival and expansion of Treg cells. The analysis of flow cytometry has...
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Design and construction of a linear hydraulic motor
Melichar, Martin ; Budík, Tomáš (referee) ; Merenus, Ondřej (advisor)
This bachelor’s thesis is interested in linear hydraulic motors. The first part consist of technical research in the field of linear hydraulic motors. The second part focuses on the construction of linear hydraulic motors including all necessary calculations. The thesis also includes technical drawings containing the total linear hydraulic motor assembly with the drawings of the top and bottom cover.
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Construction of hydraulic wood-splitting machine
Šimčík, Jaroslav ; Opl, Miroslav (referee) ; Matějka, Petr (advisor)
Bc. Jaroslav Simcik Construction of hydraulic wood-splitting machine DP, Institute of production machines, systems and robotics, 2010, p. 60, fig. 30, appendices 7, This master ´s thesis is concerned with the wood-processing technology with a focus on the construction of hydraulic wood splitter machine with a force 120 kN.
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Evaluation of corrosion on selected aluminium alloys
Skýba, Pavel ; Tulka, Jaromír (referee) ; Pacal, Bohumil (advisor)
The thesis focuses on the corrosion research of AlCu4Mg1 aluminium alloys of square shape and sheet metal coated in 99.5% aluminium. The theoretical part deals with the characteristics of aluminium, the classification and naming of aluminium alloys and the impact of admixtures on aluminium alloys. In the following chapter a general introduction to metal corrosion, its differentiation according to the type of corrosion attack, mechanisms of corrosion, the impact of corrosive environment, according to the choice of anti-corrosion protection, etc. is given. The main part is devoted to the corrosion of aluminium with a special importance of the impact of admixtures on aluminium alloys, the types of corrosion attack, the impact of corrosive environment as well as of the anti-corrosion protection of aluminium alloys. The corrosion tests in controlled atmosphere are considered in the next chapter, while the last one deals with the evaluation methodology of the process of corrosion. At the beginning of the experimental part all the used samples and materials are introduced. The thesis continues then with an overview and a description of the methods used for experiments. The measurement procedure and the results of the experiments are presented in the following chapter that focuses on the metallographic analysis of the aluminium alloy samples before the experiment and after the corrosion attack. The main part of the chapter deals with the dependence of corrosion speed of the individual aluminium alloy samples on time after being exposed in the climate chamber and the salt fog chamber
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Evaluation of Corrosion on Selected Magnesium Alloys
Pořický, Vladislav ; Tulka,, Jaromír (referee) ; Pacal, Bohumil (advisor)
This master´s thesis is focused on classification of corrosion resistivity magnesium alloy type AZ91 in environment of salt vapour testing in corrosion chambers. For tests were used samples of magnesium alloy manufactured by three different methods of casting: cast-iron mold, die vacuum casting, die casting without vacuum and method of die casting with additional pressure (squeeze casting). In this work was accomplished metallographic evaluation of corrosion attack and detailed analysis of corrosion products. Conclusions of exposits tests are assembled of analysis of influence of corrosion environment on structure of alloy. On the basis of these conclusions of corrosion tests were evaluated influences of corrosion speed [mm/year] on time [hours] for individual states of magnesium alloy.
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Set of residential buildings in SM6, Staré Město - Project planning implementation of construction
Běťák, Rostislav ; Novotný, Michal (referee) ; Šlanhof, Jiří (advisor)
The master thesis with the name Set of residential buildings in SM6, Staré Město - Project planning implementation of construction solves preparation and realization of building. The aim of master thesis is to design of time, financial, material and human resources. The thesis contains calculation, time schedule, building-site, technologicals standards, controls and trials plans, design of mechanism, study of realization of the main stages. The thesis is prepared on the basis of project documents provided by the investor with the approval of the design office.
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Design and construction of a linear hydraulic motor
Melichar, Martin ; Budík, Tomáš (referee) ; Merenus, Ondřej (advisor)
This bachelor’s thesis is interested in linear hydraulic motors. The first part consist of technical research in the field of linear hydraulic motors. The second part focuses on the construction of linear hydraulic motors including all necessary calculations. The thesis also includes technical drawings containing the total linear hydraulic motor assembly with the drawings of the top and bottom cover.
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Conveyor Inverter - Design Lifting Mechanism
Zálešák, Martin ; Kašpárek, Jaroslav (referee) ; Škopán, Miroslav (advisor)
I am concern with a proposal of conceptual solution of Conveyor Inverter in my bachelor work. This Conveyor Inverter is used for the change of the direction europallet about 90° between roller and chain conveyor according to given technical parameters. My bachelor work contains complete 3D proposal, constructional and functional solutions which are based on checking calculations. Lifting of the Conveyor Inverter is done using a leverage mechanism of electric motor.
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