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Significance of detection of human papillomaviruses in draining lymph nodes in cervical cancer paients
Sláma, Jiří ; Dundr, Pavel (advisor) ; Svoboda, Bohuslav (referee) ; Špaček, Jiří (referee)
Background: Metastatic involvement of pelvic nodes is the most important prognostic parameter in early-stage cervical cancer. Still, approximately 15% of patients with negative pelvic nodes experience recurrence, majority of them in the pelvis. The presence of HPV DNA in histology-negative pelvic nodes is considered a subclinical metastatic spread. Methods: Patients with early-stage cervical cancer referred for surgical treatment were enrolled in the study. Cytobrush technique was used for sample collection from the fresh tissue to avoid any loss of material for histology. Results: Altogether, 49 patients were enrolled in the study. High-risk (HR) HPV was identified in the tumor in 91.8% patients, and in the sentinel node or other pelvic nodes in 49.9% patients. Among the 10 HR HPV genotypes detected, HPV 16 was the most frequently represented in both the tumor and the lymph nodes (66.7% and 71.4%, respectively). All metastatic lymph nodes were HPV positive. Conclusion: The presence of HR HPV DNA in a sentinel node had a positive predictive value for metastatic involvement of pelvic lymph nodes in our study. This could be considered a sign of an early subclinical metastatic spread; however, the prognostic value has to be evaluated through a longer follow-up.
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Model for monitoring the value of enterprise Informatics: system / deterministic chaotic model
Filippi, Tomáš ; Bruckner, Tomáš (advisor) ; Palovská, Helena (referee)
This study deals with the value of ICT services. Enterprise Informatics is a widespread line of business and it is part of every company. There are not only software and hardware resources in enterprise informatics, but also people belong into and work with informatics every day. Currently, there are new trends how to manage enterprise informatics. Based on the same principles as for the business. A prerequisite for effective management is accurate overview of the costs and benefits. For this purpose there is a group of metrics which ensure measuring the amount of inputs, outputs and quality of services. The value of ICT services should be positive. Benefits should be greater than costs. The aim of this work is to create a model for monitoring the value of enterprise Informatics. Model simulate the dynamics of enterprise informatics and describe all important parameters in terms of value. Model should also find out if there are some external or internal factors, which could bring on some random element complicating the process of effective management.
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Influence of surgical technique in ACL rupture on selected rheological parameters of the knee
Kopencová, Milada ; Dudová, Agnieszka (referee) ; Říha, Michal (advisor)
Název: Vliv operační techniky u diagnózy "Ruptura LCA" na vybrané reologické parametry. Title: Influence of surgical technique in ACL rupture on selected rheological parameters of the knee. Cíl práce: Zhodnocení a porovnání změn reologických vlastností kolenního kloubu u ruptury předního zkříženého vazu před a po jejím chirurgickém ošetření a v průběhu rekonvalescence. Metoda: Experimentálního in vivo měření pasivního odporu kolenního kloubu při vynuceném pohybu do flexe a extenze metodou bioreometrie. Zhodnocení specifických reologických vlastností, které vystihují momentální stav kolenního kloubu. Vyhodnocení naměřených dat pomocí grafického znázornění sumárních reologických charakteristik - bioreogramu. Výsledky: Výsledky odhalují průběh rekonvalescence u pacientů po plastice předního zkříženého vazu. Tento průběh zachycuje specifické změny reologických charakteristik kolenního kloubu během tří měsíců, které byly patrné při vyhodnocování bioreogramů. Byly zjištěny změny tvaru křivek, které vypovídají o změnách tuhosti, disipované energie a tím i "účinnosti" kolenního kloubu během léčebného procesu. Výsledky naznačily možnost budoucího hodnocení poruch kolene právě metodou bioreometrie. Klíčová slova: bioreogram, bioreometrie, kolenní kloub, přední zkřížený vaz, rekonstrukce kolenního kloubu,...
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Hurdles run technique analysis in the 400m hurdles
Drtina, Martin ; Hojka, Vladimír (referee) ; Korbel, Vladimír (advisor)
Hurdles run technique analysis in the 400m hurdles Thesis objectives: The main objective is to compare the technique hurdles run in the race tempo on the track 400 m hurdles at the selected probands. Tasks are identified kinematic parameters separately for each proband and identify their weaknesses in technique. Method: Analysis techniques hurdles run was done by using 3D kinematic analysis. Observed space-time events were recorded on two digital cameras. Records was transferred to a suitable digital format and processed in the program TEMA. For a clearer presentation of output data from the TEMA program was used Microsoft Excel. Results: In all three probands were found deficiencies in hurdles run technique. Further differences were found in the hurdles run technique of each other probands. Keywords: Hurdle, run, technique, kinematic analysis
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Photochromic effect in nanoporous titanium dioxide film with Ag nanocrystals
Galář, Pavel ; Malý, Petr (advisor) ; Dohnalová, Kateřina (referee)
The diploma thesis is devoted to multicolour photochromic effect in nanocomposite material Ag-TiO2, which is caused by a spectrally selective photoinduced decrease in extinction. The Thesis introduces briefly the theory of particle plasmons which are of fundamental significance for the investigated phenomenon. A short summary of the models and results published on photochromic effect in Ag-TiO2 is than given. The core of thesis deals with the optimization of this nanocomposite material towards a high photochromatic response. The influence of concentration of the TiO2 solution and of the speed of its spin coating deposition on a substrate was measured. Also the effect of AgNO3 quality used for sample preparation was monitored. A change in the extinction was found to depend on parameters of the excitation laser beam too. As a part of the optimization process, also the alternative TiO2 matrixes produced on basis of lamellar micelles were tested. The photochromic effect was monitored by measurements of the light extinction and scattering in dependence on the sample photoexposition. The properties of a set of the high-quality samples were studied using photoluminescence spectroscopy. Measurements of the photoluminescence decay with subpicosecond time resolution by up-conversion technique as well as of the...
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Partial discharge
Macek, Vratislav ; Krbal, Michal (referee) ; Toman, Petr (advisor)
The main subject of this diploma’s thesis is the creation of laboratory task on the partial discharge. The thesis is made up of two parts: theoretical and practical. In the theoretical part there are information about partial discharge. One of them is classification partial discharge by type, effects of partial discharge in insulation systems, parameters to assess the quality of electrical insulation of power systems and measurement techniques. Further part is user’s manual for measurement instrument. In practical part is created laboratory task on problematic of the partial discharge measurement. It is demonstrative measure of partial discharge with the aim of understanding problematic of partial discharge, calibration and noise.
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Separation and Determination of Betamethasone and chloramphenicol in multicomponent pharmaceutical preparations using a monolithic columns coupled to sequential injection system
Salabová, Markéta ; Šatínský, Dalibor (advisor) ; Chocholouš, Petr (referee)
SEPARATION AND DETERMINATION OF BETAMETHASONE AND CHLORAMPHENICOL IN MULTICOMPONENT PHARMACEUTICAL PREPARATIONS USING A MONOLITHIC COLUMNS COUPLED TO SEQUENTIAL INJECTION SYSTEM Markéta Salabová Abstract A new separation method based on a reversed-phase sequential injection chromatography (SIC) technique was used for simultaneous determination of chloramphenicol and betamethasone in pharmaceutical eye drops in this contribution. Short monolithic column coupled with a sequential injection analysis (SIA) system enabled separation of two compounds in one step. A Chromolith Flash RP-18e, 25-4.6 mm column with 5 mm precolumn (Merck, Germany) and a FIAlab 3000 system (USA) with a 6-port selection valve and 5 ml syringe were used for sequential injection chromatographic separations in study. The mobile phase used was acetonitrile-water (30:80, v/v), flow rate 0.48 ml min-1 ; UV detection was at two wavelengths 241 nm and 278 nm, (absorption maximum of betamethasone and chloramphenicol). The basic validation parameters showed good results: linearity of determination for both compounds including internal standard (propylparaben) > 0.999; repeatability of determination (RSD) in the range 0.8 - 1.7% at two different concentration levels, and detection limits in the range 0.5 - 1.0 µg ml-1 . The chromatographic...
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Statistical techniques for Loss Given Default Modeling
Betíková, Veronika ; Vaníček, Karel (advisor) ; Zichová, Jitka (referee)
Title: Statistical techniques for Loss Given Default Modeling Author: Veronika Betíková Department: Department of Probability and Mathematical Statistics Supervisor: Mgr. Karel Vaníček Supervisor's e-mail address: karelvanicek@seznam.cz Abstract: The aim of this thesis is to introduce Loss given default as one of the parameters of credit risk. The thesis discusses the basic characters and meth- ods of LGD calculation. It also points out the common use of linear regression models and generalized linear models which are used in practice to estimate LGD parameter. Individual mathematical models and statistical methods for estima- tions of the parameters of such models are concisely described and consequently applied on simulated data. Keywords: LGD, beta regression, OLS, estimation 1
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Road I/69 Jasenná – Liptál - Study
Masnicová, Alžbeta ; Šenkýř, Miroslav (referee) ; Radimský, Michal (advisor)
The subject of this thesis is the extension of an existing road I/69 in the section Jasenná - Liptál with the climbing line and to secure the transport service at bus stops along the road. The road I/69 between the villages of Liptál and Jasenná has high elevation and inconvenient directional and height parameters. The basic objective of the study is to improve and increase comfort in this section. The work is editing width arrangements and takes to account connections of tertiary roads to the road I/69. In this work were created two variants with a width arrangement 12.5 and 13.5 meters.
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Detection of Differential Item Functioning with Non-Linear Regression: Non-IRT Approach Accounting for Guessing
Drabinová, Adéla ; Martinková, Patrícia
In this article, we present a new method for estimation of Item Response Function and for detection of uniform and non-uniform Differential Item Functioning (DIF) in dichotomous items based on Non-Linear Regression (NLR). Proposed method extends Logistic Regression (LR) procedure by including pseudoguessing parameter. NLR technique is compared to LR procedure and Lord’s and Raju’s statistics for three-parameter Item Response Theory (IRT) models in simulation study based on Graduate Management Admission Test. NLR shows superiority in power at low rejection rate over IRT methods and outperforms LR procedure in power for case of uniform DIF detection. Our research suggests that the newly proposed non-IRT procedure is an attractive and user friendly approach to DIF detection.
Fulltext: content.csg -  PDF
Plný tet: v1229-16-version2 - PDF; v1229-16 - PDF
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