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Reactions of Alkenes Iniciated by Transition Metals Alkyls and Hydrides
Nečas, David
Reactions of Alkenes Iniciated by Transition Metals Alkyls and Hydrides David Nečas Department of Organic and Nuclear Chemistry, Faculty of Science, Charles University, Hlavova 8, 128 40 Prague 2, Czech Republic. Keywords: C-C bond cleavage, C-C bond formation, Nickel, catalysis The C-C bond activation (cleavage) as well as the C-C bond formation under mild and simple reaction conditions are intensively sought after processes. In the course of this thesis new nickel based catalytic system was found suitable for formation of C-C bonds (cyclization of α,ω-dienes) and for cleavage of unactivated C-C bonds in allyl malonates and related compounds. Mechanistic and structural aspects of these reactions are also discussed as well as a relation of C-C bond formation (cyclization) to the C-C bond cleavage (deallylation). This work was supported by FRVŠ No. 42-202755, MŠMT No. 1M0508 Centre for New Antivirals and Antineoplastics, MŠMT No. LC 06070 Center for Structural and Synthetic Application of Transition Metal Complexes and is a part of the Research Project MSM0021620857.
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Network solutions with principles of systems thinking
Veselý, Luděk ; Mildeová, Stanislava (advisor) ; Exnarová, Anna (referee)
The main goal of this work is the application of system thinking in computer networks design and use of the systems thinking as a unique way of thinking and the presentation of the big potential which the systems thinking has in complex problem solving. Advanced network technologies are also described with their benefits for any organization. This thesis brings a whole new sight at the computer networks as a complex system and describes procedure of making a computer project in detail which can be used as a general reference model in the field of computer technologies. Solution include strong accent on how the basic knowledge of computer networking is important for information manager profession.
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IFRS 4 Insurance Contracts phase II
Stejskalová, Martina ; Bokšová, Jiřina (advisor) ; Randáková, Monika (referee)
Thesis deals with harmonization of financial reporting in the area of insurance contracts. IFRS 4 phase I adjusts reporting of insurance contracts, defines a term insurance contract, bans generating catastrophe provisions or equalisation provisions, show a new view at reporting of insurance contract with discretionary participation feature and at reporting embedded derivates.IFRS 4 phase II solves complex reporting of insurance contracts. The aim is to achieve "real" measurement of liabilities arising from insurance contracts. The thesis shows a measurement model form exposure draft.
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Classification of shopping centre Nový Smíchov
Dinh Thi, Quynh Nga ; Filipová, Alena (advisor) ; Zeman, Jiří (referee)
Nový Smíchov is one of the most successful shopping centre in Czech Republic. This is the reason, why I chose it as the subject of my bachelor theses. The aim of my bachelor theses is to classify shopping centre Nový Smíchov as a complex and suggest its improvement. Clear focus should be on interior and exterior design. I will analyse the structure of particular shops and point out the detail information about most important of them. At conclusion, I will identify basic deficiencies and try to suggest the best way to despatch them.
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The Cross in Changing of Times and its Significance in Ancient Society
Roule, Radek ; Lášek, Jan Blahoslav (advisor) ; Weis, Martin (referee) ; Royt, Jan (referee)
The Cross in Changing of Times and its Significance in Ancient Society The cross is the most widespread symbol appearing worldwide right from the prehistoric times. Though being formed of a very simple shape of two intersecting lines the significance is far reaching. This dissertation looks at the cross both as a sign pointing beyond itself and concentrates on the diversity of its visual appearance. It tries to trace back the possible factors preceding Antiquity influencing the formation of the actual shape in that particular period of history. Although for most part the cross is understood in its connection with the Crucifixion of Christ its history is far more complex beginning in pre-Christian era. The biblical texts present more or less mere allusions of the cross itself. Seen typologically the cross may be understood as the element connecting both Old and New Testament creating a sort of a bridge between them. The careful analysis of the Early Christian documents brings several terms used for the same reality. The most significant are - σταυρός with the Latin equivalent crux and ξύλου (wood) with the Latin equivalent lignum. Later on these give a way to a more general term of σημεῖον (sign) and finally to a symbolic expression "σύμβολον σωτηρίας" (sign-symbol of salvation). The early Christian writers...
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Evolution vs. Creation: Where the Truth Lies
Miklošová, Zoana ; Lhotský, Josef (advisor) ; Stella, Marco (referee)
The debate between creationism and evolution remains vital after 80 years. Creation Science, represented by Young- Earth Creationism (YEC) and Old-Earth Creationism (OEC), denies fact of macroevolution and postulates based on Genesis model of separately created species. Thesis submits brief description of creationistic model and compares it with Darwinian idea of descent with modification from common ancestor. Primarily, the scientific and methodological merits of Creation Science are examined. In last two decades the position of Creation Science was rather decreasing. On the other hand, new phenomenon Intelligent Design (ID) became widely known. Although philosophical starting-points similar as creationistic ones ID introduces new arguments for supernatural design. This work analyses main tenets of ID - specified complexity and irreducible complexity of organisms. Again, ID's arguments are judged on its explanatory and methodological merits in confrontation with evolutional concepts reflecting recent post-neodarwinism development in biology. Key words: Creationism, biological evolution, Darwinism, Neodarwinism, Intelligent design, falsifiability, methodological naturalism
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Postranslational modifications in DNA damage response
Moudrý, Pavel ; Hodný, Zdeněk (advisor) ; Malcová, Ivana (referee) ; Mistrík, Martin (referee)
Our genetic material is continually challenged by varieties of factors and processes that represent enormous threat to our ability to transmit genetic information to our offspring and to our survival as well. Cells possess many mechanisms capable of detecting and repairing damaged DNA, collectively known as DNA damage response (DDR). DDR activities must be tightly regulated in a spatiotemporal and DNA lesion-specific manner to optimize repair and prevent alterations in DNA during normal cellular processes. Defects in DNA repair drive genomic instability and may ultimately lead to cancer and neurodegenerative diseases. This work is a compilation of 4 projects focused on molecular mechanisms of DNA damage response and assembly of multiprotein signalling and repair complexes at sites of DNA damage. We identified nuclear pore component NUP153 as a novel factor specifically required for 53BP1 nuclear import and DDR. We showed that NUP153 knockdown prevents 53BP1 from entering the nuclei in newly forming daughter cells, which translates to decreased IR-induced 53BP1 foci formation, delayed DNA repair, impaired survival after IR and exacerbates replication stress-induced DNA damage. Furthermore, we identified ubiquitin-activating enzyme UBA1 as the apical E1 enzyme required for response to IR and replication...
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Symmetrically substituted polyazamacrocycles
Pošívalová, Kateřina ; Lorenc, Miroslav (advisor) ; Drahoňovský, Dušan (referee)
This thesis deals with the synthesis of model compounds and cyclam cyclen macro compounds for the preparation contrast agents of synthetically readily available starting materials. Result, a new macrocycle was prepared which could be used for complexation with GdIII and other measurements. Macrocycle was prepared in low yields (3.2% and 3%) Synthesis was performed 2,5,9,12-tetraazabicyclo [11.3.1] heptadecane-4,10-dione and N2 ,N5 - dibenzyl 2,5,9,12-tetraazabicyclo[11.3.1]heptadecane-4,10-dione for further processing and subsequent measurement of required quantities, which have been formally completed synthesis.
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Transfers of ownership of flats
Moncmann, Lukáš ; Oehm, Jaroslav (advisor) ; Horáček, Tomáš (referee)
The purpose of this Master's degree (diploma) thesis is to do final review and classification of regulation of transfers of ownership of flats established by act No. 72/1994 Coll. (about ownership of flats) before it will be replaced by act No. 89/2012 Coll. (the new civil code), because now is the last chance to study it as valid and effective. Withal this thesis tries to analyse differences between them, describe changes and new conditions, and find out if the new legislation deals with all issues of this subject matter and possibly come up with a solution of blind spots. The method to achieve this is creating different systematics of describing and categorizing the old statue, and effort to recognize the same complexes in the new statue. Therefore the thesis is composed of four main chapters, each of them dealing with different aspects of transfers of flats. Chapter One is introducing topic of the thesis and topic's history and defines basic terminology used in the thesis, e.g.: flat, building, (residential) unit or common parts of residential building etc. The chapter two, as one of the two most important chapters, concentrates on principles and mechanism of default case of transfer of flat including compulsory elements of its contracts, leaving aside all possible exceptions. This is followed by the...
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Homomorphic encryption and coding theory
Půlpánová, Veronika ; Hojsík, Michal (advisor) ; Šťovíček, Jan (referee)
Title: Homomorphic encryption and coding theory Author: Veronika Půlpánová Department: Department of algebra Supervisor: RNDr. Michal Hojsík, Ph.D., Department of algebra Abstract: The current mainstream in fully homomorphic encryption is the appro- ach that uses the theory of lattices. The thesis explores alternative approaches to homomorphic encryption. First we present a code-based homomorphic encrypti- on scheme by Armknecht et. al. and study its properties. Then we describe the family of cryptosystems commonly known as Polly Cracker and identify its pro- blematic aspects. The main contribution of this thesis is the design of a new fully homomorphic symmetric encryption scheme based on Polly Cracker. It proposes a new approach to overcoming the complexity of the simple Polly Cracker - based cryptosystems. It uses Gröbner bases to generate zero-dimensional ideals of po- lynomial rings over finite fields whose factor rings are then used as the rings of ciphertexts. Gröbner bases equip these rings with a multiplicative structure that is easily algorithmized, thus providing an environment for a fully homomorphic cryptosystem. Keywords: Fully homomorphic encryption, Polly Cracker, coding theory, zero- dimensional ideals
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