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Modular Analog Synthesizer
Jambor, Tomáš ; Vrba, Kamil (referee) ; Schimmel, Jiří (advisor)
The aim of this work is to get acquainted with the principle of modular analog synthesizers and circuit design used in these devices. The subtractive synthesis was chosen like a main method, which is based on a modular design principle. The theoretical part include brief history of synthesizers and electronic musical instruments, review of other methods of synthesis and detailed elaboration of principles and modules used in subtractive synthesis. The practical part of this work is implementation and measuring properties of the module voltage controlled oscillator, voltage controlled filter, low frequency oscillator and voltage controlled amplifier. There is additionally implement calculation and design circuitry for voltage controlled amplifier.
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Návrh a syntéza inhibitorů DDl založených na isothiazolidinonovém jádře
Suchanová, Klára ; Miletín, Miroslav (referee) ; Zimčík, Petr (advisor)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Chemistry and Drug control Candidate: Klára Suchanová Supervisor: doc. dr. Marko Anderluh, mag. farm.; PharmDr. Petr Zimčík, Ph.D. Title of diploma thesis: Design and synthesis of isothiazolidinone-based DDl inhibitors This work is focused on D-Ala-D-Ala ligase (DDl), enzyme in alanine side pathway of the bacterial cell wall synthesis. Potential DDl inhibitors were designed with the help of docking software (AutoDock 4.05, The Scripps Research Institute, La Jolla, USA), X-ray structures of DDl (1IOW and 1IOV, PDB), its natural substrates/products and known published inhibitors. This work is a part of the project EUR-INTAFAR (Inhibition of New TArgets for Fighting Antibiotic Resistance) aiming at better understanding of the physiology and biochemistry of bacterial cell morphogenesis and peptidoglycan biosynthesis and the discovery of new antibacterial agents. According to the in silico design, five final compounds were synthesized with isothiazolidinone core and evaluated in the biological assays to determine their DDl inhibitory potency.
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Vývoj anorganických nosičů vhodných pro depozici mikroporésních vrstev – syntéza a charakterizace
Juristová, K. ; Fíla, V. ; Andertová, J. ; Zikánová, Arlette ; Bernauer, B. ; Lhotka, M.
The present study is focused on the preparation of porous supports (ceramic, glass) and thin microporous layers (zeolite, polyaluminum chlorid (PAC), silicalite-1), which are suitable for application in the catalysis, membrane technology and biotechnology. The modification of ceramic Al2O3 support and its preparation by the slip-casting method is discussed here. The optimal conditions for modification of ceramic support using the PAC and the optimal conditions for slip-casting support design were proposed and experimentally verified. The second part of the work deals with the synthesis of boro-silicalite glass. The characterization of the supports by SEM, mercury porosimetry and by permeation measurements are discussed.
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The potential of deep seabed polymetallic nodules
Tormová, Lucia ; Dvořák, Antonín (advisor) ; Hadrabová, Alena (referee)
The deep seabed polymetallic nodules are one the major types of deep-sea ore resources. Oceanic deposits of these raw materials represent a potential source of numerous metals that are in short supply on the land-base deposits at the nearest future. The process of geological survey to the deep ocean floor is considered to be an onset of a quantitatively new stage in the process of mineral resource extraction. Continuation of the on-going work on polymetallic nodule deposits within the Clarion-Clipperton Zone is regarded as a serious task to be undertaken over a period until the year 2025, with a due consideration to advance in designing of an efficient mining unit and application of modern processing technologies for extraction of major metals : manganese, nickel, cobalt and copper. A prerequisite of a rational management of oceanic resources is the preservation of natural oceanic environment. Considered is the extraction's profitability of a concrete deposit within the Clarion-Clipperton Zone, which is the exploration area of the IOM, with annual production scale of 2.2 Mt of wet nodules for the year 2025.
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Súčasné prístupy k nákladovej alokácii a vývoj typizovaného programového rozhrania v nástroji IBM Cognos TM1
Fedoročko, Peter ; Pour, Jan (advisor) ; Bothe, Ondřej (referee)
Thesis is devoted to current trends in approaching cost allocation developed in IBM Cognos TM1 software. Concept, which was originally elaborated in my bachelor thesis, has recently experienced restrictions caused by increasing requirements on analytical tools and information they provide. Goal of the thesis is therefore to analyse causalities of emerging weaknesses, design and develop optimalized and reengineered solution answering current demands. Reqarding the quantitative evaluation of attained results, the thesis is extended with analysis of frameworks and standards dedicated to benchmarking of OLAP tools and their synthesis into own complex model. Proposed model specializes on measuring multiple OLAP applications across four main perspectives including performance, development, usability and financial benefits. Attained results prove, that reengineered model is faster, data richer, easier to use and appropriate for any organization with structured and algorithmic approach to cost allocation. Second half of the thesis focuses on extending the presentation layer to web browser, designing and developing of custom visualizations for most usual analytic tasks. Considering the absence of advanced application interface in IBM Cognos TM1, the thesis also includes theoretical analysis of current trends in API development and design of concept allowing communication and data transportation between applications and TM1 server. In the concluding section of the thesis, proposed concept is materialized into universal library developed in PHP and applied to novel allocation model. Leveraging the library, two exemplary interfaces for allocator operation and data consumption are implemented. Gained knowledge can serve as basis for development of additional components communicationg with TM1 in variety of projects or theoretical framework for API implementation in general.
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Synthesis of novel cardioprotective iron chelators
Hrušková, Kateřina ; Roh, Jaroslav (referee) ; Vávrová, Kateřina (advisor)
Oxidative stress participates in patophysiology of many serious cardiovascular diseases. Free intracellular iron occurs as a catalyst of Haber-Weiss and Fenton reaction between superoxides and peroxides increasing the formation of highly toxic hydroxyl radicals, which cause cell damage. Iron chelators diminish the pool of free iron and thus become perspective agents in therapy of various diseases, e.g. anthracycline-induced cardiotoxicity. Aroylhydrazones group, such as salicylaldehyde-isonicotinoylhydrazone (SIH), appear to be highly efficient chelators. Unfortunately, pharmacokinetic studies focused on these compounds revealed their low stability in plasma. Therefore, I synthesised a series of SIH analogs in order to increase their stability together with preserving the ability to chelate free intracellular iron and to define their structure-activity relationships. A basic hypothesis in design of the novel chelators was using substituted ketone instead of aldehyde, leading potentially to an enhanced stability of hydrazone bond. SIH Two different methods were used during the reactions, a conventional heating in an oil bath and heating in a microwave reactor. The latter caused a significant shortening of the reaction time. In vitro studies of novel compounds showed their higher stability in plasma,...
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Building trust in virtual teams through communication
Štádlerová, Michaela ; Klas, Jan (advisor) ; Jura, Jiří (referee)
The main objective of this thesis is to propose the model of trust based on communication. The objective is to first characterize virtual teams, summarized the theoretical approaches to trust in virtual teams, define the specifics of the communication process in virtual teams and design own model of trust based on communication. The proposed model is achieved on the basis of own research specifically: analysis, synthesis and detailed summary. The summary includes limitations of particular papers and weaknesses of research, what is taken into the consideration for the proposed model. The proposed model is based on the active form of trust that is build on proactive approach of team leader in the first phase of virtual team's life cycle and later on communication strategies through dialogue technique leading to shared mental models. The proposed model describes the process of building trust in first two stages of the virtual team's life cycle together with the implications for the leader: How to build trust in virtual teams through the communication.
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Web application for programming student training
Podolka, Luděk ; Pavlíček, Luboš (advisor) ; Pecinovský, Rudolf (referee)
Goal of this master thesis is to describe possible solutions for compilation, execution and unit testing of user programs written in Java hosted on web server. Another goal is to design and to implement web application which would allow students to write and to test simple programs during Java lessons. Chosen method for achieving first goal is studying relevant resources, mainly documentation and source code of projects which implement dynamic program execution. To accomplish the second goal the author uses requirements analysis and principles of agile methodology of extreme programming. Parts of UML notation are used to make the design part clear. First part is focused on theory behind dynamic program execution in Java, class loading, compilation of source code and software security. Overview of tools built upon these basic concepts follows. These are dynamic module systems, software testing tools, build automation tools and continuous integration servers. Previously mentioned tools implement dynamic program execution. Third group consists of tools for source code quality analysis which could be considered as components of application for education purposes that is to be implemented. The author summarizes the task of new application development and performs requirement analysis in the practical part. Internal structure of future application is briefly discussed by the author. The demonstration of detailed design is derived from one of user stories. Overview of tools and technologies used during the analysis, design and implementation is also part of the text. Integral part of this thesis is web application hosted on http://kitscm.vse.cz/tppv/. Authors contribution to the topic is synthesis of existing solutions to problems neccessary to analyze, design and implement working web application for program testing and the result of these processes itself.
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Painterly animation synthesis
Psotka, František ; Maršálek, Lukáš (referee) ; Pelikán, Josef (advisor)
In this work I study painterly animation synthesis using simulated brush strokes. Painterly animation, as a new artistic form, gives the animator new space and freedom. The aim of the project is to design a framework which could solve this complex task - to put together both the exibility and simplicity with user comfort. This framework should be helpful in further research of artistic and technical potential of painterly animation. Implementation the method of Barbara Meier [4] within this framework results in the application which provides a possibility of creating attractive pieces in brushwork even for less experienced animators.
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Strategic analysis of Vodafone Czech Republic a.s.
Mašek, Karel ; Smrčka, Luboš (advisor) ; Schönfeld, Jaroslav (referee)
The aim of this thesis is to design a strategy for Vodafone Czech Republic, a.s. Using the open data an analysis of macroenvironment as well as microenvironment are performed, where a definition and a breakdown of telecommunication market into five segment is made. Following is the analysis of Porter five forces, which analyses competition forces on the market as well as to the Vodafone. Further on a financial analysis and product portfolio analysis is made, which serves as the basis of Ansoff matrix. In the conclusion a synthesis of the analyses is made and several strategies are designed.
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