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Is depression related to lower weight reduction in reduction dietary regimen?
Kofránková, Jana ; Štich, Vladimír (advisor)
The topic of his thesis, depression is associated with less weight reduction in reducing dietary regime? I chose based on their interest in problems of obesity and diabetes. Obesity is now recognized as a very serious disease that worsens quality of life and shortens its duration. Along with hypertension and diabetes dyslipidemia, obesity is one of the four main diseases that in developed countries frequently cause death. The cause of obesity is disturbed balance between intake and energy expenditure, particularly excessive caloric intake and insufficient physical activity .. In the last decade, the prevalence of obesity worldwide sharply rise, experts even talk about the obesity epidemic The first part will focus on the definition, epidemiology, etiopathogenesis, diagnosis, and treatment of obesity, insulin resistance and depression. In the next section, I will summarize the current knowledge about the context of obesity, depression and insulin resistance. The third part of the thesis describes the clinical study. The study will focused on women in reducing dietary program and will seek changes in their body weight, insulin resistance, and depression. Among these factors I search context. I will try to answer the question of whether depression is associated with less reduction in weight reduction diet...
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Evaluation of technical, economical, and personal aspects of e-learning in the SAP LS system in ČSOB, a. s.
Kubeš, Tomáš ; Beroušek, Petr (advisor) ; Legnerová, Kateřina (referee)
This book focuses on an evaluation of technical, economical, and personal aspects of e-learning deployment in a theoretical plane and in the specific environment of the bank ČSOB, a. s. The thesis begins by an introduction of the term e-learning and a brief description of main properties and characteristics of this new trend in a field of not only corporate education. Special attention is devoted to an assessment of business benefits and cots of education; every aspect is analyzed and compared both for the classical brick and mortar classroom instructor led education and for the e-learning. The thesis introduces two mathematical models for assessing an effectiveness of e-learning deployment. Theoretical concepts are applied to data from a real course which was run in one of the main Czech banks ČSOB, a. s. Last part briefly examines the concepts and benefits of SCORM standard package and its support in the SAP LS 600 system.
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Sibling incest and its consequences
Ehlová, Markéta ; Junková, Vendula (referee) ; Weiss, Petr (advisor)
This work pays attention to the child sexual abuse, particularly to the sibling incest. The final work is divided into the two parts, theoretical and practical ones. The theoretical part covers family problems, syndrom CAN and its forms generally, the child sexual abuse is discussed in more detail. Attention is paid to the incest - how are affiicted families, victim's and offender's personality, and also to the prevalence. Then there are mentioned consequences of sexual abuse and incest for the victim in detail. There is introduced detailed knowledge of sibling incest at the end of the theoretical part. There are also mentioned results of the available do mestic and foreign researches covering this issue within the whole theoretical part. Practical part consists of description of research made on the basis of questionaire among group of 719 students of secondary schools in Pardubice. The questionaire was prepared exclusively tor this research and is supposed to cover presence oť sexual abuse and incest during childhood and consequencies for psychosexual development and psychopathology of abused children. There are also described aims of our research, the group of tested persons and method used in research. Result of research was statistically elaborated and valorized. There are summed up empirical results...
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Polymeric nanofibrous scaffolds reinforced with diamond and ceramic nanoparticles for bone tissue engineering
Bačáková, Lucie ; Pařízek, Martin ; Staňková, Ľubica ; Novotná, Katarína ; Douglas, T.E.L. ; Brady, M. A. ; Kromka, Alexander ; Potocký, Štěpán ; Stránská, D.
Three types of nanofibrous scaffolds were prepared by electrospining: (1) poly(lactide-co-glycoside) (PLGA) scaffolds reinforced with 23 wt.% of diamond nanoparticles (DNPs), (2) poly(L-lactide) (PLLA) scaffolds with DNPs in concentration ranging from from 0.4 wt.% to 12.3 wt.%, and (3) PLLA scaffolds with 5 wt.% or 15 wt.% of hydroxyapatite (HAp) nanoparticles. The diameter of the nanofibers ranged between 160 and 729 nm. The nanofibers with nanoparticles were thicker and the void spaces among them were smaller. Mechanical properties of the nanoparticle-loaded scaffolds were better, as demonstrated by a rupture test in scaffolds with DNPs and by a creep behavior test in scaffolds with HAp. On PLGA scaffolds with DNPs, the human osteoblast-like MG-63 cells adhered in similar numbers and grew with similar kinetics as on pure PLGA scaffolds. Human bone marrow mesenchymal stem cells grew faster and reached higher population densities on PLGA-DNP scaffolds. However, on PLLA-based scaffolds, the activity of mitochondrial enzymes and concentration of osteocalcin in MG-63 cells decreased with increasing DNP concentration. On the other hand, the metabolic activity of MG-63 cells and content of osteocalcin in these cells were positively correlated with the HAp concentration in PLLA scaffolds. Thus, PLGA nanofibers with 23 wt% of DNPs and PLLA nanofibers with 5 and particularly 15 wt.% of HAp seem to be promising for bone tissue engineering.
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Topology and function of the transmembrane domain of colicin U produced by Shigella boydii
Dolejšová, Tereza ; Fišer, Radovan (advisor) ; Krůšek, Jan (referee)
Colicin U is a protein produced by strains of bacterium Shigella boydii. It exhibits antibacterial activity against some bacterial strains Shigella and Escherichia. Based on sequence homology with colicins A, B and N, the colicin U is classified as a pore-forming colicin. Interaction of colicin U with attacked bacteria is ensured by three-step mechanism: 1) First colicin U interacts with surface receptors OmpA, OmpF and core of LPS. 2) Thereafter the colicin is translocated to periplasm through interaction with Tol proteins. 3) Finally colicin U interacts with the inner membrane of the attacked bacteria causing its depolarization. In this thesis I demonstrated pore-forming features of colicin U and further observed characteristics and properties of these pores. Using methods of measuring on black lipid membranes I determined a single channel conductance (19 pS), ion selectivity, the influence of various conditions on the behaviour of the pores. These findings, in many cases, correspond to the findings on other related colicins. Furthermore, I successfully determined the pore diameter of colicin U ( ≈ 0,8 nm). The next section of the thesis focuses on creation of single cysteine mutations of colicin U. Subsequently I produced five mutant variants of colicin U and verified their functionality so that...
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Simulace dvojrozměrného toku kolem překážek za použití "lattice-gas" celulárních automatů
Tomášik, Miroslav ; Scholtz, Martin (advisor) ; Pavelka, Michal (referee)
Cellular automata constitues original computational methods, that found its application in many disciplines. The special class of cellular automata, so called lattice gas automata were succesfull in dealing with many challenges in hydrodynamic simulations, and they bootstrap one of the most perspective CFD methods, the Lattice Boltzmann models. In the theoretical part, we follow the evolution of the lattice gas automata, explore the theory behind them, and from their microdynamics, we derive the macroscopic equations. In the practical part, we implemented two distincet types of LGCA, the pair-interaction automata and FCHC. We applied them on the flow around obstacles of various shapes. The scientifically most relevant part concerns statistical properties of the turbulent flow simmulated by LGCA, but requires further research to conclude it. Powered by TCPDF (www.tcpdf.org)
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Applications of psychology of decision-making
Bahník, Štěpán ; Sirůček, Pavel (advisor) ; Džbánková, Zuzana (referee)
This work summarizes the basics of the heuristics and biases approach. It is a psychological approach to the study of decision-making and judgment stemming from works of Daniel Kahneman and Amos Tversky. Not only did it contribute to understanding of numerous cognitive processes, which people use for deciding and making judgments, but it has many applications in various fields including economics as well. There are mentioned examples of application besides theory in this work. In particular, the covered fields are negotiation, investment decision making and marketing. Critics of depicted approach and its implications are briefly described at the end of the work.
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The role of sonication of PEO solutions with magnetic nanoparticles on morphology of the resulting nanofibrous mats
Peer, Petra ; Stěnička, M. ; Filip, Petr ; Pizúrová, Naděžda ; Babayan, V.
Properties of the resulting polymer nanofibres are often tailored by sonication technique applied prior or past an electrospinning process. The aim of this contribution is to evaluate morphology of nanofibrous mats formed by poly(ethylene oxide) with distributed magnetic nanoparticles (about 20nm in diameter) in dependence on time of sonication of the used polymer solutions. The solutions were exposed to sonication (intensity 200W, frequency 24 kHz) for 10, 30, and 60 minutes. It was shown that rheological characteristics (viscosity, storage and loss moduli) strongly depend on time of sonication (particularly phase angle) in contrast to electric conductivity and surface tension. For analysis of homogeneous distribution of magnetic field and magnetorheological efficiency (a relation of corresponding ciscosities) was process of electrospinning and resulting wuality of the obtained nanofibrous mats.
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Electrospinning of Modified Biopolymers for Medical Applications
Pavliňáková, Veronika ; Martinová,, Lenka (referee) ; Zajíčková, Lenka (referee) ; Vojtová, Lucy (advisor)
Předkládaná disertační práce se zabývá přípravou a charakterizací nových biokompatibilních nanovláken s potenciální aplikací v medicíně. V této práci byl výběr jednotlivých složek pro přípravu nanovlákenného materiálu zvolen tak, aby vyhovoval nárokům tkáňového inženýrství. Literární rešerše shrnuje poznatky o elektrostatickém zvlákňování a o jeho parametrech. Dále se věnuje možnostem elektrostatického zvlákňování proteinů kolagenu a želatiny a jejich směsmi se syntetickými polymery a biopolymery a anorganickými plnivy. Teoretická část řeší také různé postupy síťování nanovláken vedoucí ke zlepšení jejich hydrolytické stability a mechanických vlastností. Poslední část je zaměřena na anorganické nanotrubky halloysitu (HNT), které získaly svou pozornost díky svým vynikajícím fyzikálním a biologickým vlastnostem. V experimentální části byly zpracovány dvě případové studie, z nichž každá se zabývá přípravou nanovlákenných biomateriálů s potenciální aplikací v medicíně. První studie je zaměřena na přípravu a charakterizaci nových hydrolyticky stabilních antibakteriálních želatinových nanovláken modifikovaných pomocí oxidované celulózy. Unikátní inhibiční účinky nanovláken byly testovány na kmenu bakterie Escherichia coli pomocí metody chemické bioluminiscence. Kultivované buňky lidského papilárního adenokacinomu plic prokázaly dobrou adhezi a proliferaci k povrchu nanovláken. Druhá část popisuje vliv zdroje a množství anorganických halloysitových nanotrubek na strukturu a vlastnosti amfifilních nanovláken ze směsi želatiny a syntetického polykaprolaktonu. Přídavek HNT zlepšil tepelnou stabilitu, mechanické vlastnosti (jak tuhost, tak prodloužení) a snížil krystalinitu nanovláken. HNT z různých zdrojů neměl vliv na chování buněk, ale mírně ovlivnil proliferaci a životaschopnost buněk na povrchu nanovláken.
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Yellow rust protection on the wheat
Hanzalová, Alena ; Bartoš, Pavel
Heavy incidence of yellow rust in the years 2014 and 2015 has proved high deleterious effects of this rust. For this reason this publication deals with yellow rust on wheat. Rusts on wheat cause losses every year. In the years of an epidemic yield can be decreased by more than a half. Epidemics of stem rust and yellow rust occur in irregular intervals. Leaf rust causes damage every year particularly in central and southern part of Moravia. Chemical control limits yield losses, however in the case of heavy rust incidence this control particularly on susceptible cultivars is not sufficient. Repeated chemical treatments increase the costs and are limited by phytosanitary regulations. Economic and ecologic rust control consists in resistance breeding and growing resistant cultivars. Knowledge of virulence in the rust poppulation and suitable sources of resistance are prerequisites for successful resistance breeding. This publication presents a summary of data from literature on the yellow rust on wheat. Data on resistance of the grown cultivars and possibilities of the chemical control are included.
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