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Possibility of influence on the stability of seniors at the risk of falling
Nesvadbová, Barbora ; Čakrt, Ondřej (advisor) ; Radvanský, Jiří (referee)
This bachelor thesis pursues the problematic of falls among seniors and possibilities of influencing the falls by affecting the seniors' stability and balance. It present basic information about causes and consequence of falls among seniors and discusses possibilities of prevention of falls through a physiotherapy and movement. Further, it shows summary and any results of studies that aimed to influence the stability and prevention of the falls among seniors through various forms of physiotherapy. Most of these studies present the significance of balance and coordination exercises combined with resistance and endurance lokomotor training. The most frequent results of physiotherapy containing these elements are the improvement of the balance functions, the increase of muscle strength, the reduction of falls and the decrease of anxiety of falling. This bachelor thesis also includes a practical part containing casuistics of two patients at the risk of falling. After eight-week therapy of balance and fitness character, there was an improvement of several parameters of functional balance tests in both cases. There was also a questionnaire inquiry focused on the frequency of falls among seniors. There is a positive effect on the reduction of falls among seniors figuring from the results.
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Translation reinitiation mechanism on mRNA of trascriptional activator GCN4.
Vlčková, Vladislava ; Valášek, Leoš (advisor) ; Strachotová, Dita (referee)
Translation reinitiation is a gene-specific translational control mechanism exploiting the ability of some short upstream open reading frames (uORFs) to retain post-termination 40S ribosomal subunit on the mRNA. Reinitiation efficiency depends on cis-acting sequences surrounding the uORF, translation elongation rates on the uORF, selected initiation factors, and the intercistronic distance of the short uORF from the main ORF. Although the precise mechanism of reinitiation is still not known, great progress in elucidating some of its details has been recently made with help of the GCN4 translational control model system. Among them, involvement of eIF3 was shown to play a critical role for efficiency of this process. In particular, it was proposed that eIF3 specifically interacts with sequences located upstream of a reinitiation-permissive uORF upon termination, and that this step is instrumental in stabilizing the 40S ribosomal subunit on the mRNA to allow subsequent resumption of scanning for reinitiation downstream. In this thesis, the current knowledge of the translation reinitiation mechanism is summarized. As a typical example, the yeast transcriptional activator GCN4 has been chosen, the mRNA of which is subjected to a tight translational control via the very reinitiation mechanism.
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Metabolism of uric acid during mammalian evolution
Mančíková, Andrea ; Krylov, Vladimír (advisor) ; Stibůrková, Blanka (referee)
Uric acid is the end product of purine metabolism of humans and some higher primates. In other mammals enzyme urate oxidase is capable to further convert uric acid to allantoin. During evolution of primates several mutations in urate oxidase gene had occured, led the enzyme to decrease its activity or to complete loss of function. What was the initial impetus for the utilization of uric acid and what biochemical traits of uric acid led to a tendency to retain a major of this metabolite production in the bloodstream? Uric acid has antioxidant capabilities and it is scavanger of free radicals. Increased levels of uric acid in blood has an effect on acute and chronic elevations of blood pressure. It is possible that hyperuricemia helped to maintain blood pressure under low-salt dietary conditions of primates during the Miocene. This mechanism probably have allowed to stabilize bipedalism our ancestors. Uric acid has an important role as a neuroprotector. As inhibitor the permeability blood-brain barrier, uric acid limits the infiltration of undesirable substances to the neurons and prevents central nervous system against the formation of inflammatory diseases. Such as neurodegenerative diseases may be caused by reduced serum uric acid levels. Uric acid protects against peroxinitrite damage tissues in the...
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Dental pulp stem cells
Suchánek, Jakub ; Koberová Ivančaková, Romana (advisor) ; Kukletová, Martina (referee) ; Hampl, Aleš (referee)
The aim of this dissertation study was to optimize the isolation and long term cultivation protocols for human dental pulp stem cells. The protocols which showed best results were used for cultivation of dental pulp stem cell isolated from exfoliated teeth (SHED). Additional aims were to characterize DPSC and SHED and prove their ability to proliferate over Hayflick's limit and differentiate into mature cell lines (osteoblasts, chondroblasts and adipocytes). In order to find optimal protocols for isolation of dental pulp from tooth, we tried three different approaches. During optimization of cultivation protocol we focused on decreasing amount of fetal calf serum (FCS) from 10 % FCS in cultivation media (most often used in literature) into 2 % and thus get closer to cultivation conditions suitable for clinical usage. We compared DPSC cultivated in three different media (medium with 10 % FCS, 2 % FCS supplemented with growth factors and media with 2 % FCS supplemented with ITS and growth factors). For characterization of DPSC and SHED we used basic biological properties (proliferation activity, viability, morphology), their phenotype and karyotype. The study demonstrated that the best protocol for isolation of dental pulp from tooth was to break the roots and extract the pulp throw this aperture. We...
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Catalytic and Electronic Properties of Redox-Active Metalloenzymes and Transition-Metal Complexes: Insights from the Computational Chemistry.
Srnec, Martin ; Rulíšek, Lubomír (advisor) ; Himo, Fahmi (referee) ; Papai, Imre (referee)
Charles University in Prague Faculty of Science Department of Modeling of Chemical Properties of Bio- and Nanostructures Catalytic and Electronic Properties of Redox-Active Metalloenzymes and Transition- Metal Complexes: Insights from the Computational Chemistry Dissertation Thesis Abstract RNDr. Martin Srnec Supervisor: Mgr. Lubomír Rulíšek, CSc. Institute of Organic Chemistry and Biochemistry AS CR Center for Biomolecules and Complex Molecular Systems Praha 2010 Introduction Metals and their ions play a key role in maintaining life. They frequently promote protein folding, the stabilization of protein scaffolds, enzymatic activity, energy conversion, intra- and intercellular signals etc. Several decades ago, metalloproteins were considered as a rather small group of proteins. Nowadays, one-third of enzymes are estimated to contain one or more metal ions, whose presence is crucial for their enzymatic functionality. Metalloenzymes participate most often in the catalysis of difficult chemical reactions (e.g. the hydroxylation of methane, decomposition of H2 into protons and electrons, N2 and O2 bond cleavage and many other examples), in oxidation-reduction and electron-transfer reactions, and in the catalysis of spin-forbidden reactions, where relativistic effects (i.e. spin-orbit coupling) are necessary....
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Physiotherapy in the treatment of primary dysmenorrhoea
Nedbalová, Anna ; Ježková, Martina (advisor) ; Vacová, Eva (referee)
The aim of this thesis was to evaluate the impact of physiotherapy and exerClse frequency on primary dysmenorrhea in a group of nine women with primary dysmenorrhea. The incidence of joint dysfunctions and muscle trigger points in comparison with a control group was also examined. The women participated in individual and group physiotherapy and performed special exercises at home. Soft tissue and joint mobilisation techniques, dynamic neuromuscular stabilization according to Kolar and exercises according to Mojzisova were used. In most cases physiotherapy had positive effect on dysmenorrhea, especially in reducing low back pain during menstruation. There was higher incidence of trigger points and joint dysfunctions in the group with primary dysmenorrhea, in particular in the pelvic region. Women with higher exercise frequency experienced less severe dysmenorrhea. Powered by TCPDF (www.tcpdf.org)
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Analysis of financial management of Czech industrial firms from 2002 to 2006.
Kuna, Petr ; Marek, Petr (advisor) ; Dufková, Eva (referee)
The aim of this thesis is to execute a financial analysis of the Czech industry from 2002 to 2006. The fundamental categories of indicators were analysed - profitability, activity, cost, debt and liqudity ratios. The analysis wasnt executed only for the whole industry but for its branches divided by NACE classification. The outcome of my research is a statement that all fundamental categories of indicators developed positively. The most obvious positive development can be observed at return on assets which was caused by shortening of assets turnover and increasing of return on revenues. Furthermore, the improvement of debt and liquidity ratios of Czech industrial firms indicates that during the analysed time period the financial stability was increased.
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Financial analysis AERO VODOCHODY a.s.
Vybíralová, Petra ; Sieber, Martina (advisor) ; Horník, Tomáš (referee)
This bachelor thesis is focused on financial analysis of AERO VODOCHODY a.s. The main goal is to assess the financial stability. Analysis was made over the years 2002 - 2007. In the first part the thesis describes the principle of financial analysis. Theoretical part describes instruments and methods of calculation which was used in this thesis. Practical part describes brief description of the company and calculations of particular instruments. Vertical and horizontal analyses, ratio indicators, concretely indicators of profitability, activity, liquidity and indebtedness, balance rulers, net worth capital, Altman index, Index IN05, indicator EVA and comparison intercompany was used in this thesis. All recognized values always have verbal commentary. All results and situation of the company are summarized in the end of this thesis.
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Financial statements and financial analysis
Skučková, Hana ; Cardová, Zdenka (advisor) ; Strouhal, Jiří (referee)
Financial analysis is very important in making decisions and also has some dificulties. The first part is about sources of information for financial analysis (balance sheet, income statement, cash flow, annual reports etc.). The second part describes elementary methods of financial analysis. Mainly methods of calculation, interpretation and usage of ratios for the purpose of firm's financial health evaluation (profitability, liquidity, financial stability etc.). The third part is about history of brewing indurstry, history and present of Pivovar Holba, a. s. There are calculated indicators and are compared with branch average and median.
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Financial analysis of company Air navigation services of the Czech republic
Bernat, Matyáš ; Staňková, Anna (advisor) ; Marek, Petr (referee)
This bachelor´s thesis deals with financial analysis of a company Air navigation services of the Czech Republic. It is divided into three parts. The first part describes methods, users and sources of financial analysis. The second part is focused on the description of company´s core business and it´s structure. The last part consists of horizontal and vertical analysis and analysis of several selected ratio indicators. We subsequently test financial stability with one bankrupcy and one solvency model both of which prove that the company is in a stable financial situation with minimal chance of entering bankruptcy. Such result is essential for the company´s core business.
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